ReDisulphID

a tool for identifying redox-active disulphides from structures

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Vitamin K-dependent protein C

Intermolecular
Cysteine 319 and cysteine 183
Cysteine 319 and cysteine 175
Intramolecular
Cysteine 92 and cysteine 111
Cysteine 59 and cysteine 64
Cysteine 105 and cysteine 120
Cysteine 122 and cysteine 131
Cysteine 147 and cysteine 160
Cysteine 162 and cysteine 175
Cysteine 101 and cysteine 106
Cysteine 140 and cysteine 151
More...
Cysteine 398 and cysteine 426
Cysteine 373 and cysteine 387
Cysteine 238 and cysteine 254
Cysteine 120 and cysteine 131
Cysteine 105 and cysteine 111
Cysteine 147 and cysteine 151
Cysteine 105 and cysteine 131
Cysteine 111 and cysteine 120
Cysteine 140 and cysteine 147
Cysteine 151 and cysteine 160
Cysteine 120 and cysteine 122
Cysteine 92 and cysteine 120
Cysteine 92 and cysteine 105
Cysteine 105 and cysteine 122
Cysteine 140 and cysteine 160
Cysteine 106 and cysteine 131
Cysteine 106 and cysteine 120
Cysteine 160 and cysteine 175
Cysteine 92 and cysteine 131
Cysteine 147 and cysteine 175
Cysteine 160 and cysteine 162
Cysteine 105 and cysteine 106
Cysteine 111 and cysteine 131
Cysteine 101 and cysteine 120
Cysteine 101 and cysteine 131
Cysteine 106 and cysteine 122
Cysteine 101 and cysteine 105
Cysteine 147 and cysteine 162
Cysteine 92 and cysteine 122
Cysteine 111 and cysteine 122
Cysteine 92 and cysteine 106
Cysteine 175 and cysteine 183
A redox-regulated disulphide may form between two units of Vitamin K-dependent protein C at these cysteines.

Relevent regions

Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
2.815574
seq distance
0
chain
G
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
2.815574
seq distance
0
chain
G
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
2.8204875
seq distance
0
chain
I
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
2.8204875
seq distance
0
chain
I
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
5.735581
seq distance
20
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
5.735581
seq distance
20
chain
I
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
5.735581
seq distance
20
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
5.735581
seq distance
20
chain
I
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
5.735581
seq distance
7
chain
I
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
5.735581
seq distance
7
chain
I
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
6.1214914
seq distance
2
chain
G
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
6.1214914
seq distance
2
chain
G
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
7.7256746
seq distance
2
chain
G
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
7.7256746
seq distance
2
chain
G
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
7.8343363
seq distance
76
chain
G
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
7.8343363
seq distance
76
chain
G
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
8.270474
seq distance
75
chain
G
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
8.270474
seq distance
75
chain
G
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
8.700332
seq distance
2
chain
I
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
8.700332
seq distance
2
chain
I
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
8.865883
seq distance
34
chain
I
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
8.865883
seq distance
34
chain
I
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
10.306098
seq distance
8
chain
I
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
10.306098
seq distance
8
chain
I
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
10.769291
seq distance
5
chain
I
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
10.769291
seq distance
5
chain
I
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
12.329478
seq distance
22
chain
I
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
12.329478
seq distance
22
chain
I
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
12.617282
seq distance
96
chain
G
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
12.617282
seq distance
96
chain
G
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
13.606205
seq distance
7
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
13.606205
seq distance
7
chain
G
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
13.606205
seq distance
7
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
13.606205
seq distance
7
chain
G
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
13.789742
seq distance
93
chain
G
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
13.789742
seq distance
93
chain
G
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
14.223862
seq distance
99
chain
G
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
14.223862
seq distance
99
chain
G
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
14.2622795
seq distance
36
chain
I
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
14.2622795
seq distance
36
chain
I
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
14.37787
seq distance
126
chain
G
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
14.37787
seq distance
126
chain
G
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
14.814859
seq distance
10
chain
G
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
14.814859
seq distance
10
chain
G
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
15.299613
seq distance
5
chain
G
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
15.299613
seq distance
5
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
16.16786
seq distance
79
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
16.16786
seq distance
79
chain
G
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
16.173702
seq distance
54
chain
G
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
16.173702
seq distance
54
chain
G
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
16.451889
seq distance
38
chain
I
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
16.451889
seq distance
38
chain
I
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
16.597797
seq distance
122
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
16.597797
seq distance
122
chain
G
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
16.89991
seq distance
8
chain
G
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
16.89991
seq distance
8
chain
G
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
16.95386
seq distance
21
chain
G
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
16.95386
seq distance
21
chain
G
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
17.241371
seq distance
9
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
17.241371
seq distance
9
chain
G
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
17.241371
seq distance
9
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
17.241371
seq distance
9
chain
G
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
17.52285
seq distance
125
chain
G
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
17.52285
seq distance
125
chain
G
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
18.740366
seq distance
38
chain
I
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
18.740366
seq distance
38
chain
I
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
18.847795
seq distance
117
chain
G
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
18.847795
seq distance
117
chain
G
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
19.137629
seq distance
99
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
19.137629
seq distance
99
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
19.137629
seq distance
99
chain
G
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
19.137629
seq distance
99
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
19.137629
seq distance
99
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
19.137629
seq distance
99
chain
G
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
19.395605
seq distance
18
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
19.395605
seq distance
18
chain
G
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
19.395605
seq distance
18
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
19.395605
seq distance
18
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
19.461227
seq distance
101
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
19.461227
seq distance
101
chain
G
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
20.12137
seq distance
48
chain
G
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
20.12137
seq distance
48
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
20.258614
seq distance
44
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
20.258614
seq distance
44
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
21.401064
seq distance
15
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
21.401064
seq distance
15
chain
G
Charge relay system
position
402
score
100.0
distance
21.649513
seq distance
83
chain
G
Charge relay system
position
402
score
100.0
distance
21.649513
seq distance
83
chain
G
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
21.929531
seq distance
66
chain
G
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
21.929531
seq distance
66
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
21.945484
seq distance
69
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
21.945484
seq distance
69
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
21.945484
seq distance
69
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
21.945484
seq distance
69
chain
G
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
21.994888
seq distance
82
chain
G
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
21.994888
seq distance
82
chain
G
Charge relay system
position
299
score
100.0
distance
22.267746
seq distance
20
chain
G
Charge relay system
position
299
score
100.0
distance
22.267746
seq distance
20
chain
G
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
22.884281
seq distance
38
chain
G
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
22.884281
seq distance
38
chain
G
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
23.24926
seq distance
21
chain
G
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
23.24926
seq distance
21
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
24.592289
seq distance
114
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
24.592289
seq distance
114
chain
G
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
25.267994
seq distance
24
chain
G
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
25.267994
seq distance
24
chain
G
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
25.34613
seq distance
50
chain
G
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
25.34613
seq distance
50
chain
G
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
25.540405
seq distance
66
chain
G
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
25.540405
seq distance
66
chain
G
Charge relay system
position
253
score
100.0
distance
25.540405
seq distance
66
chain
G
Charge relay system
position
253
score
100.0
distance
25.540405
seq distance
66
chain
G
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
25.85211
seq distance
30
chain
G
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
25.85211
seq distance
30
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
26.277403
seq distance
22
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
26.277403
seq distance
22
chain
G
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
27.65749
seq distance
47
chain
G
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
27.65749
seq distance
47
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
27.78643
seq distance
104
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
27.78643
seq distance
104
chain
G
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
28.742205
seq distance
38
chain
G
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
28.742205
seq distance
38
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
29.194818
seq distance
48
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
29.194818
seq distance
48
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
29.194818
seq distance
48
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
29.194818
seq distance
48
chain
G
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
29.590622
seq distance
75
chain
G
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
29.590622
seq distance
75
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
30.08247
seq distance
107
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
30.08247
seq distance
107
chain
G
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
32.590435
seq distance
73
chain
G
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
32.590435
seq distance
73
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
33.054195
seq distance
25
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
33.054195
seq distance
25
chain
G
Phosphoserine; by FAM20C
position
347
score
100.0
distance
33.555496
seq distance
28
chain
G
Phosphoserine; by FAM20C
position
347
score
100.0
distance
33.555496
seq distance
28
chain
G
4-carboxyglutamate
position
349
score
50.0
distance
36.66546
seq distance
30
chain
G
4-carboxyglutamate
position
349
score
50.0
distance
36.66546
seq distance
30
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
42.718716
seq distance
False
chain
K
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
42.718716
seq distance
False
chain
K
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
51.19171
seq distance
False
chain
A
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
51.19171
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
51.656704
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
51.656704
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
51.656704
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
51.656704
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
52.443863
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
52.443863
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
54.992878
seq distance
False
chain
K
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
54.992878
seq distance
False
chain
K
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
55.476162
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
55.476162
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
57.62687
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
57.62687
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
58.58721
seq distance
False
chain
J
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
58.58721
seq distance
False
chain
J
4-carboxyglutamate
position
349
score
50.0
distance
60.482857
seq distance
False
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
60.482857
seq distance
False
chain
A
Charge relay system
position
7
score
50.0
distance
60.901466
seq distance
False
chain
K
Charge relay system
position
7
score
50.0
distance
60.901466
seq distance
False
chain
K
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
61.869358
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
61.869358
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
62.072628
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
62.072628
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
62.072628
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
62.072628
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
62.072628
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
62.072628
seq distance
False
chain
A
Phosphoserine; by FAM20C
position
347
score
100.0
distance
63.545975
seq distance
False
chain
A
Phosphoserine; by FAM20C
position
347
score
100.0
distance
63.545975
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
64.825874
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
64.825874
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
65.06951
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
65.06951
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
66.2009
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
66.2009
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
67.050415
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
67.050415
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
67.47676
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
67.47676
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
67.688126
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
67.688126
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
67.70454
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
67.70454
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
68.49284
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
68.49284
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
68.55847
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
68.55847
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
68.81129
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
68.81129
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
68.81129
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
68.81129
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
69.11935
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
69.11935
seq distance
False
chain
A
Charge relay system
position
402
score
100.0
distance
69.12219
seq distance
False
chain
A
Charge relay system
position
402
score
100.0
distance
69.12219
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
69.60867
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
69.60867
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
70.251076
seq distance
False
chain
K
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
70.251076
seq distance
False
chain
K
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
70.779274
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
70.779274
seq distance
False
chain
A
Charge relay system
position
7
score
50.0
distance
71.41139
seq distance
False
chain
H
Charge relay system
position
7
score
50.0
distance
71.41139
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
72.73317
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
72.73317
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
73.38086
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
73.38086
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
73.38699
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
73.38699
seq distance
False
chain
A
Charge relay system
position
253
score
100.0
distance
73.38699
seq distance
False
chain
A
Charge relay system
position
253
score
100.0
distance
73.38699
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
74.20548
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
74.20548
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
74.24444
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
74.24444
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
74.51205
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
74.51205
seq distance
False
chain
A
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
74.76013
seq distance
False
chain
A
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
74.76013
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
75.38118
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
75.38118
seq distance
False
chain
B
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
76.39047
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
76.39047
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
76.573715
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
76.573715
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
76.573715
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
76.573715
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
76.92783
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
76.92783
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
77.56672
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
77.56672
seq distance
False
chain
B
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
77.87679
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
77.87679
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
77.87679
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
77.87679
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
77.97773
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
77.97773
seq distance
False
chain
A
Charge relay system
position
299
score
100.0
distance
78.28238
seq distance
False
chain
A
Charge relay system
position
299
score
100.0
distance
78.28238
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
78.978645
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
78.978645
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
79.9971
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
79.9971
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
80.59253
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
80.59253
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
81.937805
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
81.937805
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
82.07641
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
82.07641
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
82.354904
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
82.354904
seq distance
False
chain
A
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
83.37933
seq distance
False
chain
B
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
83.37933
seq distance
False
chain
B
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
83.70627
seq distance
False
chain
B
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
83.70627
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
83.707825
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
83.707825
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
83.72815
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
83.72815
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
84.29498
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
84.29498
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
84.91665
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
84.91665
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
85.306816
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
85.306816
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
85.56643
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
85.56643
seq distance
False
chain
A
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
85.586815
seq distance
False
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
85.586815
seq distance
False
chain
B
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
85.586815
seq distance
False
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
85.586815
seq distance
False
chain
B
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
86.52697
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
86.52697
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
87.41814
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
87.41814
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
87.69261
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
87.69261
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
89.60453
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
89.60453
seq distance
False
chain
A
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
90.995415
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
90.995415
seq distance
False
chain
A
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
90.995415
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
90.995415
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
91.94069
seq distance
False
chain
L
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
91.94069
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
91.94834
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
91.94834
seq distance
False
chain
B
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
92.090004
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
92.090004
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
92.22763
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
92.22763
seq distance
False
chain
B
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
92.40179
seq distance
False
chain
B
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
92.40179
seq distance
False
chain
B
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
95.28643
seq distance
False
chain
C
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
95.28643
seq distance
False
chain
C
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
95.55853
seq distance
False
chain
B
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
95.55853
seq distance
False
chain
B
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
96.69853
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
96.69853
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
98.60293
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
98.60293
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
98.60293
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
98.60293
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
98.633484
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
98.633484
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
101.615685
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
101.615685
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
102.54956
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
102.54956
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
102.54956
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
102.54956
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
102.732346
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
102.732346
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
105.802155
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
105.802155
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
105.802155
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
105.802155
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
105.802155
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
105.802155
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
107.65074
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
107.65074
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
108.25988
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
108.25988
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
109.06888
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
109.06888
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
110.20743
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
110.20743
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
110.47026
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
110.47026
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
110.48604
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
110.48604
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
110.87535
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
110.87535
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
111.55666
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
111.55666
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
112.410065
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
112.410065
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
113.2107
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
113.2107
seq distance
False
chain
D
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
113.22861
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
113.22861
seq distance
False
chain
C
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
113.6798
seq distance
False
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
113.6798
seq distance
False
chain
D
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
114.08466
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
114.08466
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
114.27952
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
114.27952
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
114.27952
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
114.27952
seq distance
False
chain
C
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
114.43154
seq distance
False
chain
D
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
114.43154
seq distance
False
chain
D
Charge relay system
position
402
score
100.0
distance
114.52916
seq distance
False
chain
C
Charge relay system
position
402
score
100.0
distance
114.52916
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
115.24906
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
115.24906
seq distance
False
chain
C
Charge relay system
position
253
score
100.0
distance
115.24906
seq distance
False
chain
C
Charge relay system
position
253
score
100.0
distance
115.24906
seq distance
False
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
115.51948
seq distance
False
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
115.51948
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
117.6237
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
117.6237
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
118.399765
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
118.399765
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
118.722305
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
118.722305
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
347
score
100.0
distance
119.36744
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
347
score
100.0
distance
119.36744
seq distance
False
chain
C
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
119.47593
seq distance
False
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
119.47593
seq distance
False
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
119.47593
seq distance
False
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
119.47593
seq distance
False
chain
D
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
119.67323
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
119.67323
seq distance
False
chain
C
Charge relay system
position
299
score
100.0
distance
119.811584
seq distance
False
chain
C
Charge relay system
position
299
score
100.0
distance
119.811584
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
120.56087
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
120.56087
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
121.23161
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
121.23161
seq distance
False
chain
C
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
121.2809
seq distance
False
chain
C
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
121.2809
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
122.27349
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
122.27349
seq distance
False
chain
D
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
122.40791
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
122.40791
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
122.69109
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
122.69109
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
122.70528
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
122.70528
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
122.96076
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
122.96076
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
123.32232
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
123.32232
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
123.600914
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
123.600914
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
124.398186
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
124.398186
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
124.42985
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
124.42985
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
124.62803
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
124.62803
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
125.05788
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
125.05788
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
125.62182
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
125.62182
seq distance
False
chain
D
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
127.0669
seq distance
False
chain
F
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
127.0669
seq distance
False
chain
F
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
127.0786
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
127.0786
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
127.21371
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
127.21371
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
127.21371
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
127.21371
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
128.90135
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
128.90135
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
129.65569
seq distance
False
chain
F
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
129.65569
seq distance
False
chain
F
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
129.80551
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
129.80551
seq distance
False
chain
D
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
130.97723
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
130.97723
seq distance
False
chain
C
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
131.32466
seq distance
False
chain
C
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
131.32466
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
131.49629
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
131.49629
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
132.47398
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
132.47398
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
132.88428
seq distance
False
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
132.88428
seq distance
False
chain
D
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
133.2758
seq distance
False
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
133.2758
seq distance
False
chain
C
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
133.2758
seq distance
False
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
133.2758
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
134.62743
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
134.62743
seq distance
False
chain
C
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
134.96782
seq distance
False
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
134.96782
seq distance
False
chain
D
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
139.8658
seq distance
False
chain
F
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
139.8658
seq distance
False
chain
F
Charge relay system
position
7
score
50.0
distance
140.08943
seq distance
False
chain
F
Charge relay system
position
7
score
50.0
distance
140.08943
seq distance
False
chain
F
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
149.40007
seq distance
False
chain
E
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
149.40007
seq distance
False
chain
E

Details

Redox score
74.35
PDB code
6m3c
Structure name
hapc-h1573 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
2.03
Half-sphere exposure sum
86
Minimum pKa
nan
% buried
nan
Peptide A name
Vitamin K-dependent protein C
Peptide B name
Vitamin K-dependent protein C
Peptide A accession
P04070
Peptide B accession
P04070
Peptide A residue number
319
Peptide B residue number
183
A redox-regulated disulphide may form between two units of Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
2.8171544
seq distance
0
chain
B
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
2.8171544
seq distance
0
chain
B
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
2.8171544
seq distance
0
chain
B
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
2.8171544
seq distance
0
chain
B
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
2.8364062
seq distance
0
chain
A
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
2.8364062
seq distance
0
chain
A
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
3.6382372
seq distance
8
chain
B
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
3.6382372
seq distance
8
chain
B
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
4.5266395
seq distance
26
chain
B
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
4.5266395
seq distance
26
chain
B
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
5.086458
seq distance
14
chain
B
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
5.086458
seq distance
14
chain
B
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
5.8850713
seq distance
12
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
5.8850713
seq distance
12
chain
B
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
5.8850713
seq distance
12
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
5.8850713
seq distance
12
chain
B
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
6.764775
seq distance
28
chain
B
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
6.764775
seq distance
28
chain
B
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
7.2080827
seq distance
2
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
7.2080827
seq distance
2
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
7.646462
seq distance
2
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
7.646462
seq distance
2
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
8.679057
seq distance
76
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
8.679057
seq distance
76
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
9.930151
seq distance
75
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
9.930151
seq distance
75
chain
A
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
9.948221
seq distance
6
chain
B
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
9.948221
seq distance
6
chain
B
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
10.670596
seq distance
3
chain
B
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
10.670596
seq distance
3
chain
B
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
11.248189
seq distance
30
chain
B
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
11.248189
seq distance
30
chain
B
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
11.812452
seq distance
30
chain
B
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
11.812452
seq distance
30
chain
B
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
12.120113
seq distance
96
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
12.120113
seq distance
96
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
13.693635
seq distance
93
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
13.693635
seq distance
93
chain
A
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
13.861853
seq distance
5
chain
A
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
13.861853
seq distance
5
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
14.171259
seq distance
99
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
14.171259
seq distance
99
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
14.860966
seq distance
126
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
14.860966
seq distance
126
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
14.873607
seq distance
7
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
14.873607
seq distance
7
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
14.873607
seq distance
7
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
14.873607
seq distance
7
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
16.273743
seq distance
79
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
16.273743
seq distance
79
chain
A
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
16.513727
seq distance
9
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
16.513727
seq distance
9
chain
A
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
16.513727
seq distance
9
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
16.513727
seq distance
9
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
16.536839
seq distance
10
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
16.536839
seq distance
10
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
16.636023
seq distance
122
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
16.636023
seq distance
122
chain
A
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
16.693197
seq distance
8
chain
A
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
16.693197
seq distance
8
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
16.883064
seq distance
21
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
16.883064
seq distance
21
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
17.178837
seq distance
54
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
17.178837
seq distance
54
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
17.959835
seq distance
125
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
17.959835
seq distance
125
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
18.60738
seq distance
117
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
18.60738
seq distance
117
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
18.638815
seq distance
99
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
18.638815
seq distance
99
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
18.638815
seq distance
99
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
18.638815
seq distance
99
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
18.638815
seq distance
99
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
18.638815
seq distance
99
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
19.329096
seq distance
101
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
19.329096
seq distance
101
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
19.773203
seq distance
48
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
19.773203
seq distance
48
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
19.823479
seq distance
18
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
19.823479
seq distance
18
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
19.823479
seq distance
18
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
19.823479
seq distance
18
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
19.97223
seq distance
44
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
19.97223
seq distance
44
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
21.282566
seq distance
15
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
21.282566
seq distance
15
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
21.446276
seq distance
69
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
21.446276
seq distance
69
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
21.446276
seq distance
69
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
21.446276
seq distance
69
chain
A
Charge relay system
position
402
score
100.0
distance
21.728739
seq distance
83
chain
A
Charge relay system
position
402
score
100.0
distance
21.728739
seq distance
83
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
21.840881
seq distance
66
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
21.840881
seq distance
66
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
22.031923
seq distance
82
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
22.031923
seq distance
82
chain
A
Charge relay system
position
299
score
100.0
distance
22.23029
seq distance
20
chain
A
Charge relay system
position
299
score
100.0
distance
22.23029
seq distance
20
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
23.165163
seq distance
21
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
23.165163
seq distance
21
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
24.369669
seq distance
38
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
24.369669
seq distance
38
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
24.458897
seq distance
114
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
24.458897
seq distance
114
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
24.997587
seq distance
50
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
24.997587
seq distance
50
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
25.405186
seq distance
24
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
25.405186
seq distance
24
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
25.554878
seq distance
66
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
25.554878
seq distance
66
chain
A
Charge relay system
position
253
score
100.0
distance
25.554878
seq distance
66
chain
A
Charge relay system
position
253
score
100.0
distance
25.554878
seq distance
66
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
26.019838
seq distance
False
chain
J
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
26.019838
seq distance
False
chain
J
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
26.186842
seq distance
22
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
26.186842
seq distance
22
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
26.202255
seq distance
30
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
26.202255
seq distance
30
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
27.675207
seq distance
104
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
27.675207
seq distance
104
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
27.90947
seq distance
47
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
27.90947
seq distance
47
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
28.638914
seq distance
38
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
28.638914
seq distance
38
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
29.133106
seq distance
48
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
29.133106
seq distance
48
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
29.133106
seq distance
48
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
29.133106
seq distance
48
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
29.191187
seq distance
75
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
29.191187
seq distance
75
chain
A
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
29.828876
seq distance
107
chain
A
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
29.828876
seq distance
107
chain
A
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
32.151245
seq distance
73
chain
A
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
32.151245
seq distance
73
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
33.11792
seq distance
25
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
33.11792
seq distance
25
chain
A
Phosphoserine; by FAM20C
position
347
score
100.0
distance
33.585697
seq distance
28
chain
A
Phosphoserine; by FAM20C
position
347
score
100.0
distance
33.585697
seq distance
28
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
36.520123
seq distance
30
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
36.520123
seq distance
30
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
42.439793
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
42.439793
seq distance
False
chain
H
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
46.743977
seq distance
False
chain
G
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
46.743977
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
47.266388
seq distance
False
chain
F
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
47.266388
seq distance
False
chain
F
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
49.482037
seq distance
False
chain
C
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
49.482037
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
50.29461
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
50.29461
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
50.29461
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
50.29461
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
50.605923
seq distance
False
chain
K
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
50.605923
seq distance
False
chain
K
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
51.22013
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
51.22013
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
54.280914
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
54.280914
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
54.375237
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
54.375237
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
55.409267
seq distance
False
chain
G
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
55.409267
seq distance
False
chain
G
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
56.341362
seq distance
False
chain
G
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
56.341362
seq distance
False
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
56.852905
seq distance
False
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
56.852905
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
57.27703
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
57.27703
seq distance
False
chain
G
4-carboxyglutamate
position
349
score
50.0
distance
57.327995
seq distance
False
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
57.327995
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
57.80532
seq distance
False
chain
L
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
57.80532
seq distance
False
chain
L
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
58.713123
seq distance
False
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
58.713123
seq distance
False
chain
G
Charge relay system
position
7
score
50.0
distance
58.747063
seq distance
False
chain
K
Charge relay system
position
7
score
50.0
distance
58.747063
seq distance
False
chain
K
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
59.15595
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
59.15595
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
59.180336
seq distance
False
chain
K
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
59.180336
seq distance
False
chain
K
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
59.20822
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
59.20822
seq distance
False
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
59.443527
seq distance
False
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
59.443527
seq distance
False
chain
G
Charge relay system
position
7
score
50.0
distance
59.75007
seq distance
False
chain
H
Charge relay system
position
7
score
50.0
distance
59.75007
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
59.888474
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
59.888474
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
59.888474
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
59.888474
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
60.218285
seq distance
False
chain
F
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
60.218285
seq distance
False
chain
F
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
60.320137
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
60.320137
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
60.496952
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
60.496952
seq distance
False
chain
G
Phosphoserine; by FAM20C
position
347
score
100.0
distance
60.608704
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
347
score
100.0
distance
60.608704
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
347
score
100.0
distance
61.05013
seq distance
False
chain
G
Phosphoserine; by FAM20C
position
347
score
100.0
distance
61.05013
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
61.20775
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
61.20775
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
61.20775
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
61.20775
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
61.20775
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
61.20775
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
61.30072
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
61.30072
seq distance
False
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
61.905964
seq distance
False
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
61.905964
seq distance
False
chain
G
4-carboxyglutamate
position
349
score
50.0
distance
61.91234
seq distance
False
chain
G
4-carboxyglutamate
position
349
score
50.0
distance
61.91234
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
62.57484
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
62.57484
seq distance
False
chain
G
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
63.334553
seq distance
False
chain
G
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
63.334553
seq distance
False
chain
G
Charge relay system
position
7
score
50.0
distance
63.85465
seq distance
False
chain
F
Charge relay system
position
7
score
50.0
distance
63.85465
seq distance
False
chain
F
Charge relay system
position
299
score
100.0
distance
63.954353
seq distance
False
chain
G
Charge relay system
position
299
score
100.0
distance
63.954353
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
64.103
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
64.103
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
64.56099
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
64.56099
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
65.24585
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
65.24585
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
65.44646
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
65.44646
seq distance
False
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
65.4657
seq distance
False
chain
C
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
65.4657
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
65.71582
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
65.71582
seq distance
False
chain
G
Charge relay system
position
253
score
100.0
distance
65.71582
seq distance
False
chain
G
Charge relay system
position
253
score
100.0
distance
65.71582
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
65.84253
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
65.84253
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
66.232124
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
66.232124
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
66.60626
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
66.60626
seq distance
False
chain
C
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
66.64216
seq distance
False
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
66.64216
seq distance
False
chain
G
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
66.64216
seq distance
False
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
66.64216
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
66.926
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
66.926
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
67.006256
seq distance
False
chain
G
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
67.006256
seq distance
False
chain
G
Charge relay system
position
402
score
100.0
distance
67.096146
seq distance
False
chain
G
Charge relay system
position
402
score
100.0
distance
67.096146
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
67.29574
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
67.29574
seq distance
False
chain
C
Charge relay system
position
402
score
100.0
distance
67.34875
seq distance
False
chain
C
Charge relay system
position
402
score
100.0
distance
67.34875
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
67.36942
seq distance
False
chain
F
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
67.36942
seq distance
False
chain
F
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
67.44115
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
67.44115
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
67.83827
seq distance
False
chain
G
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
67.83827
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
68.141235
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
68.141235
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
68.29693
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
68.29693
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
68.29693
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
68.29693
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
68.49636
seq distance
False
chain
G
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
68.49636
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
68.612465
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
68.612465
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
68.71703
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
68.71703
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
69.5101
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
69.5101
seq distance
False
chain
G
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
69.576416
seq distance
False
chain
I
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
69.576416
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
69.885605
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
69.885605
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
70.046425
seq distance
False
chain
K
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
70.046425
seq distance
False
chain
K
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
70.25624
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
70.25624
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
70.26814
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
70.26814
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
70.76611
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
70.76611
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
70.76611
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
70.76611
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
71.10513
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
71.10513
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
71.25047
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
71.25047
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
71.32631
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
71.32631
seq distance
False
chain
C
Charge relay system
position
253
score
100.0
distance
71.32631
seq distance
False
chain
C
Charge relay system
position
253
score
100.0
distance
71.32631
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
71.886284
seq distance
False
chain
G
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
71.886284
seq distance
False
chain
G
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
72.12792
seq distance
False
chain
C
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
72.12792
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
72.4373
seq distance
False
chain
G
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
72.4373
seq distance
False
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
72.85364
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
72.85364
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
73.40353
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
73.40353
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
73.67821
seq distance
False
chain
I
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
73.67821
seq distance
False
chain
I
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
73.87016
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
73.87016
seq distance
False
chain
G
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
73.896545
seq distance
False
chain
G
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
73.896545
seq distance
False
chain
G
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
73.95184
seq distance
False
chain
G
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
73.95184
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
74.67148
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
74.67148
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
74.69039
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
74.69039
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
74.855705
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
74.855705
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
74.855705
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
74.855705
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
75.29415
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
75.29415
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
75.98915
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
75.98915
seq distance
False
chain
C
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
75.99243
seq distance
False
chain
I
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
75.99243
seq distance
False
chain
I
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
76.252144
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
76.252144
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
76.252144
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
76.252144
seq distance
False
chain
C
Charge relay system
position
299
score
100.0
distance
76.271194
seq distance
False
chain
C
Charge relay system
position
299
score
100.0
distance
76.271194
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
76.598076
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
76.598076
seq distance
False
chain
D
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
76.62311
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
76.62311
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
77.340485
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
77.340485
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
77.551605
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
77.551605
seq distance
False
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
77.55826
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
77.55826
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
78.35476
seq distance
False
chain
G
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
78.35476
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
78.57098
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
78.57098
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
78.79575
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
78.79575
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
79.15898
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
79.15898
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
79.31175
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
79.31175
seq distance
False
chain
I
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
79.75801
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
79.75801
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
80.03245
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
80.03245
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
80.65886
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
80.65886
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
81.42006
seq distance
False
chain
G
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
81.42006
seq distance
False
chain
G
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
81.43165
seq distance
False
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
81.43165
seq distance
False
chain
I
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
81.43165
seq distance
False
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
81.43165
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
81.79796
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
81.79796
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
81.81431
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
81.81431
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
82.2859
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
82.2859
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
82.340675
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
82.340675
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
82.38843
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
82.38843
seq distance
False
chain
C
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
82.661446
seq distance
False
chain
D
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
82.661446
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
82.744385
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
82.744385
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
82.94891
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
82.94891
seq distance
False
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
83.129234
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
83.129234
seq distance
False
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
83.129234
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
83.129234
seq distance
False
chain
G
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
83.15726
seq distance
False
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
83.15726
seq distance
False
chain
D
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
83.47207
seq distance
False
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
83.47207
seq distance
False
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
83.47207
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
83.47207
seq distance
False
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
83.47207
seq distance
False
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
83.47207
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
83.77864
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
83.77864
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
83.975815
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
83.975815
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
84.03956
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
84.03956
seq distance
False
chain
C
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
84.66479
seq distance
False
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
84.66479
seq distance
False
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
84.66479
seq distance
False
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
84.66479
seq distance
False
chain
D
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
84.949455
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
84.949455
seq distance
False
chain
G
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
85.01093
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
85.01093
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
85.033424
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
85.033424
seq distance
False
chain
I
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
85.29033
seq distance
False
chain
E
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
85.29033
seq distance
False
chain
E
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
86.06258
seq distance
False
chain
G
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
86.06258
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
87.002846
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
87.002846
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
87.08262
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
87.08262
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
88.074646
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
88.074646
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
88.323364
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
88.323364
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
89.00437
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
89.00437
seq distance
False
chain
I
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
89.70923
seq distance
False
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
89.70923
seq distance
False
chain
C
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
89.70923
seq distance
False
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
89.70923
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
90.033485
seq distance
False
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
90.033485
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
90.033485
seq distance
False
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
90.033485
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
91.105545
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
91.105545
seq distance
False
chain
C
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
91.3362
seq distance
False
chain
I
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
91.3362
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
91.47722
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
91.47722
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
91.50127
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
91.50127
seq distance
False
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
91.81495
seq distance
False
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
91.81495
seq distance
False
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
95.00166
seq distance
False
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
95.00166
seq distance
False
chain
D

Details

Redox score
63.48
PDB code
6m3c
Structure name
hapc-h1573 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
9.41
Half-sphere exposure sum
74
Minimum pKa
nan
% buried
nan
Peptide A name
Vitamin K-dependent protein C
Peptide B name
Vitamin K-dependent protein C
Peptide A accession
P04070
Peptide B accession
P04070
Peptide A residue number
319
Peptide B residue number
175
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
2.8276103
seq distance
0
chain
D
EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
2.8276103
seq distance
0
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
4.355136
seq distance
7
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
4.355136
seq distance
7
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
4.355136
seq distance
7
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
4.355136
seq distance
7
chain
D
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
5.5333467
seq distance
9
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
5.5333467
seq distance
9
chain
D
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
5.5333467
seq distance
9
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
5.5333467
seq distance
9
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
9.272193
seq distance
2
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
9.272193
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
11.335391
seq distance
5
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
11.335391
seq distance
5
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
12.234903
seq distance
3
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
12.234903
seq distance
3
chain
D
EGF-like 2
begin
94
end
134
score
100.0
distance
14.798254
seq distance
25
chain
D
EGF-like 2
begin
94
end
134
score
100.0
distance
14.798254
seq distance
25
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
17.201836
seq distance
22
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
17.201836
seq distance
22
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
17.201836
seq distance
22
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
17.201836
seq distance
22
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
17.201836
seq distance
22
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
17.201836
seq distance
22
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
21.572556
seq distance
50
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
21.572556
seq distance
50
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
22.913233
seq distance
64
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
22.913233
seq distance
64
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
23.650396
seq distance
67
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
23.650396
seq distance
67
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
24.47288
seq distance
36
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
24.47288
seq distance
36
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
26.23107
seq distance
33
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
26.23107
seq distance
34
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
26.23107
seq distance
33
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
26.23107
seq distance
34
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
26.752436
seq distance
52
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
26.752436
seq distance
52
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
26.752436
seq distance
52
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
26.752436
seq distance
52
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
26.84863
seq distance
38
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
26.84863
seq distance
38
chain
D
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
30.918346
seq distance
False
chain
A
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
30.918346
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
31.733673
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
31.733673
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
32.41971
seq distance
70
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
32.41971
seq distance
70
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
32.625637
seq distance
72
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
32.625637
seq distance
72
chain
D
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
32.677284
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
32.677284
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
36.184345
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
36.184345
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
36.83745
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
36.83745
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
37.503593
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
37.503593
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
38.113705
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
38.113705
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
39.058857
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
39.058857
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
39.058857
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
39.058857
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
39.19099
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
39.19099
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
39.986965
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
39.986965
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
40.789093
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
40.789093
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
43.11678
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
43.11678
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
43.68385
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
43.68385
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
44.951324
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
44.951324
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
45.2315
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
45.2315
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
46.14974
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
46.14974
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
46.588253
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
46.588253
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
46.83999
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
46.83999
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
46.905518
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
46.905518
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
46.905518
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
46.905518
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
47.00426
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
47.00426
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
47.53097
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
47.53097
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
47.53097
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
47.53097
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
47.53097
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
47.53097
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
47.958992
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
47.958992
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
48.663563
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
48.663563
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
49.015408
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
49.015408
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
49.267822
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
49.267822
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
49.34681
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
49.34681
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
49.952736
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
49.952736
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
49.982964
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
49.982964
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
50.07566
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
50.07566
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
50.07566
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
50.07566
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
50.1446
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
50.1446
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
50.846786
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
50.846786
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
52.275192
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
52.275192
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
52.787365
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
52.787365
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
53.583763
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
53.583763
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
53.926105
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
53.926105
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
54.534786
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
54.534786
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
54.534786
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
54.534786
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
57.26846
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
57.26846
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
57.32647
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
57.32647
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
57.474373
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
57.474373
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
59.17618
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
59.17618
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
59.17618
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
59.17618
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
59.69478
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
59.69478
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
59.729176
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
59.729176
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
60.102432
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
60.102432
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
61.20427
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
61.20427
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
73.52207
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
73.52207
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
78.49025
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
78.49025
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
92.58396
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
92.58396
seq distance
False
chain
C
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
112.56755
seq distance
False
chain
B
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
112.56755
seq distance
False
chain
B

Details

Redox score
78.3
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
2.03
Half-sphere exposure sum
nan
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
92 (Residue 50 in this structure)
Residue number B
111 (Residue 69 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

In Yonago; defective anticoagulant activity.
original residue
R
variation residue
G
position
15
score
63.63636363636363
distance
7.420624
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs574949343.
original residue
R
variation residue
Q
position
15
score
63.63636363636363
distance
7.420624
seq distance
2
chain
D
In THPH3; dbSNP:rs757583846.
original residue
R
variation residue
W
position
15
score
63.63636363636363
distance
7.420624
seq distance
2
chain
D
In Yonago; defective anticoagulant activity.
original residue
R
variation residue
G
position
15
score
63.63636363636363
distance
7.420624
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs574949343.
original residue
R
variation residue
Q
position
15
score
63.63636363636363
distance
7.420624
seq distance
2
chain
D
In THPH3; dbSNP:rs757583846.
original residue
R
variation residue
W
position
15
score
63.63636363636363
distance
7.420624
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs199469481.
original residue
K
variation residue
E
position
28
score
72.72727272727273
distance
8.255729
seq distance
6
chain
D
In patients with PROC deficiency; dbSNP:rs199469481.
original residue
K
variation residue
E
position
28
score
72.72727272727273
distance
8.255729
seq distance
6
chain
D
In patients with PROC deficiency; dbSNP:rs764546127.
original residue
R
variation residue
C
position
9
score
72.72727272727273
distance
13.441903
seq distance
8
chain
D
In patients with PROC deficiency; dbSNP:rs764546127.
original residue
R
variation residue
C
position
9
score
72.72727272727273
distance
13.441903
seq distance
8
chain
D
Peptidase S1
begin
77
end
78
score
89.77272727272727
distance
22.136118
seq distance
False
chain
B
Peptidase S1
begin
77
end
78
score
89.77272727272727
distance
22.136118
seq distance
False
chain
B
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
130
score
54.54545454545454
distance
29.00256
seq distance
False
chain
B
In THPH4; Muenchen.
original residue
R
variation residue
H
position
130
score
54.54545454545454
distance
29.00256
seq distance
False
chain
B
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
130
score
54.54545454545454
distance
29.00256
seq distance
False
chain
B
In THPH4; Muenchen.
original residue
R
variation residue
H
position
130
score
54.54545454545454
distance
29.00256
seq distance
False
chain
B
Gla
begin
166
end
166
score
65.9090909090909
distance
36.655777
seq distance
False
chain
B
Gla
begin
166
end
166
score
65.9090909090909
distance
36.655777
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs199469481.
original residue
K
variation residue
E
position
28
score
72.72727272727273
distance
44.975616
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469481.
original residue
K
variation residue
E
position
28
score
72.72727272727273
distance
44.975616
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs764546127.
original residue
R
variation residue
C
position
9
score
72.72727272727273
distance
48.112953
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs764546127.
original residue
R
variation residue
C
position
9
score
72.72727272727273
distance
48.112953
seq distance
False
chain
C
In Yonago; defective anticoagulant activity.
original residue
R
variation residue
G
position
15
score
63.63636363636363
distance
48.463013
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs574949343.
original residue
R
variation residue
Q
position
15
score
63.63636363636363
distance
48.463013
seq distance
False
chain
C
In THPH3; dbSNP:rs757583846.
original residue
R
variation residue
W
position
15
score
63.63636363636363
distance
48.463013
seq distance
False
chain
C
In Yonago; defective anticoagulant activity.
original residue
R
variation residue
G
position
15
score
63.63636363636363
distance
48.463013
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs574949343.
original residue
R
variation residue
Q
position
15
score
63.63636363636363
distance
48.463013
seq distance
False
chain
C
In THPH3; dbSNP:rs757583846.
original residue
R
variation residue
W
position
15
score
63.63636363636363
distance
48.463013
seq distance
False
chain
C
Peptidase S1
begin
77
end
78
score
89.77272727272727
distance
55.949352
seq distance
False
chain
A
Peptidase S1
begin
77
end
78
score
89.77272727272727
distance
55.949352
seq distance
False
chain
A
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
130
score
54.54545454545454
distance
75.69923
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
130
score
54.54545454545454
distance
75.69923
seq distance
False
chain
A
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
130
score
54.54545454545454
distance
75.69923
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
130
score
54.54545454545454
distance
75.69923
seq distance
False
chain
A
Gla
begin
166
end
166
score
65.9090909090909
distance
79.48191
seq distance
False
chain
A
Gla
begin
166
end
166
score
65.9090909090909
distance
79.48191
seq distance
False
chain
A

Details

Redox score
78.23
PDB code
3jtc
Structure name
importance of mg2+ in the ca2+-dependent folding of the gamma- carboxyglutamic acid domains of vitamin k-dependent clotting and anticlotting proteins
Structure deposition date
2009-09-11
Thiol separation (Å)
2.26
Half-sphere exposure sum
nan
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
59 (Residue 17 in this structure)
Residue number B
64 (Residue 22 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
2.802989
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
2.802989
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
2.802989
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
2.802989
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
2.802989
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
2.802989
seq distance
0
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
4.6703596
seq distance
4
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
4.6703596
seq distance
4
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.554597
seq distance
1
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.554597
seq distance
1
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
6.9978385
seq distance
3
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
6.9978385
seq distance
3
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
7.504991
seq distance
2
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
7.504991
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
7.504991
seq distance
2
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
7.504991
seq distance
2
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
7.504991
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
7.504991
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
11.334469
seq distance
13
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
11.334469
seq distance
13
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
11.334469
seq distance
13
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
11.334469
seq distance
13
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
11.334469
seq distance
13
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
11.334469
seq distance
13
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
13.125033
seq distance
6
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
13.125033
seq distance
6
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
17.740208
seq distance
16
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
17.740208
seq distance
16
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
20.221151
seq distance
24
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
20.221151
seq distance
25
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
20.221151
seq distance
24
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
20.221151
seq distance
25
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
20.997341
seq distance
27
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
20.997341
seq distance
27
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
22.181
seq distance
False
chain
C
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
22.181
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
24.796381
seq distance
55
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
24.796381
seq distance
55
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
25.675264
seq distance
29
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
25.675264
seq distance
29
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
27.86767
seq distance
41
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
27.86767
seq distance
41
chain
L
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
29.922586
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
29.922586
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
30.651379
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
30.651379
seq distance
False
chain
C
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
31.451483
seq distance
43
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
31.451483
seq distance
43
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
31.451483
seq distance
43
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
31.451483
seq distance
43
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
32.392654
seq distance
58
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
32.392654
seq distance
58
chain
L
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
32.88086
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
32.88086
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
34.28037
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
34.28037
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
34.448414
seq distance
63
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
34.448414
seq distance
63
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
36.57469
seq distance
61
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
36.57469
seq distance
61
chain
L
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
36.644474
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
36.644474
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
38.090786
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
38.090786
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
38.146782
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
38.146782
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
38.146782
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
38.146782
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
38.571
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
38.571
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
38.86117
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
38.86117
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
39.071983
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
39.071983
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
40.881416
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
40.881416
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
40.906174
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
40.906174
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
41.65773
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
41.65773
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
41.65773
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
41.65773
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
41.65773
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
41.65773
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
41.838734
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
41.838734
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
41.838734
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
41.838734
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
42.594845
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
42.594845
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
42.611954
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
42.611954
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
42.667492
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
42.667492
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
42.878174
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
42.878174
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
42.935463
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
42.935463
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
43.813057
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
43.813057
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
43.866253
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
43.866253
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
44.270332
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
44.270332
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
44.304058
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
44.304058
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
45.78019
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
45.78019
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
46.016735
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
46.016735
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
47.64421
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
47.64421
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
47.673386
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
47.673386
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
47.912914
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
47.912914
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
48.146782
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
48.146782
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
48.637775
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
48.637775
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
48.71828
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
48.71828
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
48.98223
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
48.98223
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
49.3614
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
49.3614
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
50.036877
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
50.036877
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
50.036877
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
50.036877
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
50.23794
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
50.23794
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
51.096004
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
51.096004
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
53.774593
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
53.774593
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
53.774593
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
53.774593
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
54.123486
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
54.123486
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
54.1597
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
54.1597
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
54.40558
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
54.40558
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
54.74234
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
54.74234
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
54.74234
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
54.74234
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
56.33576
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
56.33576
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
57.440857
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
57.440857
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
57.576454
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
57.576454
seq distance
False
chain
C

Details

Redox score
77.12
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
2.03
Half-sphere exposure sum
57
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
105 (Residue 63 in this structure)
Residue number B
120 (Residue 78 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
2.7661178
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
2.7661178
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
2.816018
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
2.816018
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
2.816018
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
2.816018
seq distance
0
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
4.0853834
seq distance
13
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
4.0853834
seq distance
13
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
4.981074
seq distance
14
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
4.981074
seq distance
14
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.4883623
seq distance
16
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.4883623
seq distance
16
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
7.7305503
seq distance
2
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
7.7305503
seq distance
2
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
7.7305503
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
7.7305503
seq distance
2
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
7.7305503
seq distance
2
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
7.7305503
seq distance
2
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
11.193612
seq distance
4
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
11.193612
seq distance
4
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
11.193612
seq distance
4
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
11.193612
seq distance
4
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
11.193612
seq distance
4
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
11.193612
seq distance
4
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
12.404548
seq distance
5
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
12.404548
seq distance
5
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
14.781962
seq distance
13
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
14.781962
seq distance
14
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
14.781962
seq distance
13
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
14.781962
seq distance
14
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
15.782294
seq distance
16
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
15.782294
seq distance
16
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
16.21351
seq distance
8
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
16.21351
seq distance
8
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
18.296467
seq distance
False
chain
C
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
18.296467
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
20.398487
seq distance
44
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
20.398487
seq distance
44
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
20.777483
seq distance
18
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
20.777483
seq distance
18
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
22.699535
seq distance
30
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
22.699535
seq distance
30
chain
L
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
25.411146
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
25.411146
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
26.566637
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
26.566637
seq distance
False
chain
C
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
26.673706
seq distance
32
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
26.673706
seq distance
32
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
26.673706
seq distance
32
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
26.673706
seq distance
32
chain
L
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
27.988394
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
27.988394
seq distance
False
chain
C
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
28.535576
seq distance
47
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
28.535576
seq distance
47
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
30.40879
seq distance
52
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
30.40879
seq distance
52
chain
L
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.65385
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.65385
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
32.923428
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
32.923428
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
33.020992
seq distance
50
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
33.020992
seq distance
50
chain
L
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.668705
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.668705
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.668705
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.668705
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
34.802547
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
34.802547
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
34.83895
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
34.83895
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
34.91151
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
34.91151
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
35.85135
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
35.85135
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
36.500763
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
36.500763
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
37.65143
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
37.65143
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
37.668007
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
37.668007
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
38.17123
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
38.17123
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
38.492447
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
38.492447
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
38.544727
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
38.544727
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
38.619267
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
38.619267
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
38.619267
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
38.619267
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
39.018818
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
39.018818
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
39.2743
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
39.2743
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
39.2743
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
39.2743
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
39.2743
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
39.2743
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
39.283424
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
39.283424
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.331978
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.331978
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
40.3849
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
40.3849
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
40.629185
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
40.629185
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
41.511185
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
41.511185
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
42.034245
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
42.034245
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
43.93757
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
43.93757
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
43.99384
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
43.99384
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
44.08984
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
44.08984
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
44.177597
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
44.177597
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
44.323456
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
44.323456
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
44.47291
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
44.47291
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.137737
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.137737
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
45.420406
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
45.420406
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
45.420406
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
45.420406
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
45.691883
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
45.691883
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
46.247936
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
46.247936
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
48.879585
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
48.879585
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
49.13312
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
49.13312
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
49.47967
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
49.47967
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
49.47967
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
49.47967
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.84952
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.84952
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
51.879047
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
51.879047
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
52.178833
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
52.178833
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
52.178833
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
52.178833
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
52.22334
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
52.22334
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
53.195618
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
53.195618
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.780785
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.780785
seq distance
False
chain
C

Details

Redox score
76.92
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
2.03
Half-sphere exposure sum
54
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
122 (Residue 80 in this structure)
Residue number B
131 (Residue 89 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

EGF-like 2
begin
94
end
134
score
100.0
distance
2.77255
seq distance
0
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
2.77255
seq distance
0
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
2.8525193
seq distance
0
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
2.8525193
seq distance
0
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
4.5710063
seq distance
2
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
4.5710063
seq distance
2
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
4.5710063
seq distance
2
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
4.5710063
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
6.1528945
seq distance
1
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
6.1528945
seq distance
1
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
7.0023923
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
7.0023923
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
8.86714
seq distance
15
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
8.86714
seq distance
15
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
9.877879
seq distance
False
chain
C
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
9.877879
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
10.684929
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
10.684929
seq distance
False
chain
C
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
11.957167
seq distance
3
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
11.957167
seq distance
3
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
11.957167
seq distance
3
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
11.957167
seq distance
3
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
12.938042
seq distance
22
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
12.938042
seq distance
22
chain
L
EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
12.938042
seq distance
15
chain
L
EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
12.938042
seq distance
15
chain
L
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
13.295033
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
13.295033
seq distance
False
chain
C
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
13.7583
seq distance
23
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
13.7583
seq distance
23
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
15.6044
seq distance
14
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
15.6044
seq distance
14
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
15.6044
seq distance
14
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
15.6044
seq distance
14
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
15.6044
seq distance
14
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
15.6044
seq distance
14
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
17.005173
seq distance
18
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
17.005173
seq distance
18
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
18.65659
seq distance
23
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
18.65659
seq distance
23
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
20.275946
seq distance
39
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
20.275946
seq distance
39
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
20.47874
seq distance
38
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
20.47874
seq distance
38
chain
L
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
21.738556
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
21.738556
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
22.378277
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
22.378277
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
22.44626
seq distance
21
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
22.44626
seq distance
21
chain
L
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
22.659231
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
22.659231
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
22.732807
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
22.732807
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
23.032188
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
23.032188
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
23.278738
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
23.278738
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
23.34058
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
23.34058
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
23.712063
seq distance
41
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
23.712063
seq distance
41
chain
L
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
24.033579
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
24.033579
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
24.398584
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
24.398584
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
25.785095
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
25.785095
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
26.218374
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
26.218374
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
26.399788
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
26.399788
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
26.561401
seq distance
29
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
26.561401
seq distance
29
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
26.561401
seq distance
29
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
26.561401
seq distance
29
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
26.561401
seq distance
29
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
26.561401
seq distance
29
chain
L
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
26.889263
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
26.889263
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
27.124573
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
27.124573
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
27.124573
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
27.124573
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
28.474804
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
28.474804
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
28.825123
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
28.825123
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
28.825123
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
28.825123
seq distance
False
chain
C
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
28.906525
seq distance
33
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
28.906525
seq distance
33
chain
L
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
29.269798
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
29.269798
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
29.64061
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
29.64061
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
29.962555
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
29.962555
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
29.980967
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
29.980967
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
30.146673
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
30.146673
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
31.016956
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
31.016956
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
31.016956
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
31.016956
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
31.158466
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
31.158466
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
31.31999
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
31.31999
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
31.928099
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
31.928099
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
32.719593
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
32.719593
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
32.952927
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
32.952927
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
32.952927
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
32.952927
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
32.952927
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
32.952927
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
32.970825
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
32.970825
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
33.29812
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
33.29812
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
33.70336
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
33.70336
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
34.306305
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
34.306305
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
35.904808
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
35.904808
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
36.501698
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
36.501698
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
36.501698
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
36.501698
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
36.930355
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
36.930355
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
37.55549
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
37.55549
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
38.66065
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
38.66065
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
40.607872
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
40.607872
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
42.76939
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
42.76939
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
43.99084
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
43.99084
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
44.31289
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
44.31289
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
44.31289
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
44.31289
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
46.034206
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
46.034206
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
51.450756
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
51.450756
seq distance
False
chain
C

Details

Redox score
76.65
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
2.02
Half-sphere exposure sum
71
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
147 (Residue 105 in this structure)
Residue number B
160 (Residue 118 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
2.8134441
seq distance
0
chain
B
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
2.8134441
seq distance
0
chain
B
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
2.8171544
seq distance
0
chain
B
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
2.8171544
seq distance
0
chain
B
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
4.420592
seq distance
1
chain
B
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
4.420592
seq distance
1
chain
B
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
4.5266395
seq distance
13
chain
B
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
4.5266395
seq distance
13
chain
B
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
6.1067195
seq distance
1
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
6.1067195
seq distance
1
chain
B
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
6.1067195
seq distance
1
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
6.1067195
seq distance
1
chain
B
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
6.764775
seq distance
15
chain
B
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
6.764775
seq distance
15
chain
B
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
9.334539
seq distance
False
chain
A
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
9.334539
seq distance
False
chain
A
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
9.642078
seq distance
3
chain
B
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
9.642078
seq distance
3
chain
B
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
10.871368
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
10.871368
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
11.248189
seq distance
17
chain
B
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
11.248189
seq distance
17
chain
B
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
11.606043
seq distance
8
chain
B
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
11.606043
seq distance
8
chain
B
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
11.812452
seq distance
17
chain
B
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
11.812452
seq distance
17
chain
B
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
13.861853
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
13.861853
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
15.039638
seq distance
6
chain
B
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
15.039638
seq distance
6
chain
B
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
16.217192
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
16.217192
seq distance
False
chain
A
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
16.513727
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
16.513727
seq distance
False
chain
A
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
16.513727
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
16.513727
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
17.332521
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
17.332521
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
17.536161
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
17.536161
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
17.626385
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
17.626385
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
20.304262
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
20.304262
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
20.447275
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
20.447275
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
21.027168
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
21.027168
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
21.455002
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
21.455002
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
21.733734
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
21.733734
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
21.733734
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
21.733734
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
22.420307
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
22.420307
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
22.994017
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
22.994017
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
23.565323
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
23.565323
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
23.901064
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
23.901064
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
23.990124
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
23.990124
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
25.183374
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
25.183374
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
25.234837
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
25.234837
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
25.458357
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
25.458357
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
26.26201
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
26.26201
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
26.310543
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
26.310543
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
26.310543
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
26.310543
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
26.310543
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
26.310543
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
26.727144
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
26.727144
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
26.727144
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
26.727144
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
26.933558
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
26.933558
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
27.178734
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
27.178734
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
27.206308
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
27.206308
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
27.573175
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
27.573175
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
27.573175
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
27.573175
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
28.00417
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
28.00417
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
29.296228
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
29.296228
seq distance
False
chain
A
Charge relay system
position
299
score
100.0
distance
29.309048
seq distance
False
chain
A
Charge relay system
position
299
score
100.0
distance
29.309048
seq distance
False
chain
A
Charge relay system
position
402
score
100.0
distance
30.30196
seq distance
False
chain
A
Charge relay system
position
402
score
100.0
distance
30.30196
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
30.758242
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
30.758242
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
30.977993
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
30.977993
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
32.086327
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
32.086327
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
32.298473
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
32.298473
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
32.83268
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
32.83268
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
33.612946
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
33.612946
seq distance
False
chain
A
Charge relay system
position
253
score
100.0
distance
33.612946
seq distance
False
chain
A
Charge relay system
position
253
score
100.0
distance
33.612946
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
33.857166
seq distance
False
chain
J
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
33.857166
seq distance
False
chain
J
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
34.10647
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
34.10647
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
34.730225
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
34.730225
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
35.442204
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
35.442204
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
36.6107
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
36.6107
seq distance
False
chain
A
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
36.897236
seq distance
False
chain
A
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
36.897236
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
37.222126
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
37.222126
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
37.28242
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
37.28242
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
38.044533
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
38.044533
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
38.044533
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
38.044533
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
39.859768
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
39.859768
seq distance
False
chain
A
Phosphoserine; by FAM20C
position
347
score
100.0
distance
41.158245
seq distance
False
chain
A
Phosphoserine; by FAM20C
position
347
score
100.0
distance
41.158245
seq distance
False
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
44.79852
seq distance
False
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
44.79852
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
47.266388
seq distance
False
chain
F
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
47.266388
seq distance
False
chain
F
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
48.629143
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
48.629143
seq distance
False
chain
H
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
49.875103
seq distance
False
chain
C
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
49.875103
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
53.05801
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
53.05801
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
53.05801
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
53.05801
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
54.586937
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
54.586937
seq distance
False
chain
C
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
55.162937
seq distance
False
chain
G
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
55.162937
seq distance
False
chain
G
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
55.62531
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
55.62531
seq distance
False
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
57.327995
seq distance
False
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
57.327995
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
58.631306
seq distance
False
chain
K
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
58.631306
seq distance
False
chain
K
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
59.392246
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
59.392246
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
60.218285
seq distance
False
chain
F
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
60.218285
seq distance
False
chain
F
Phosphoserine; by FAM20C
position
347
score
100.0
distance
60.608704
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
347
score
100.0
distance
60.608704
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
61.32389
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
61.32389
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
62.482178
seq distance
False
chain
L
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
62.482178
seq distance
False
chain
L
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
63.46338
seq distance
False
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
63.46338
seq distance
False
chain
G
Charge relay system
position
7
score
50.0
distance
63.85465
seq distance
False
chain
F
Charge relay system
position
7
score
50.0
distance
63.85465
seq distance
False
chain
F
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
63.97216
seq distance
False
chain
G
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
63.97216
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
64.27025
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
64.27025
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
64.27025
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
64.27025
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
64.27025
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
64.27025
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
64.74218
seq distance
False
chain
H
Charge relay system
position
7
score
50.0
distance
64.74218
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
65.17748
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
65.17748
seq distance
False
chain
G
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
65.28242
seq distance
False
chain
G
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
65.28242
seq distance
False
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
65.4657
seq distance
False
chain
C
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
65.4657
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
65.719795
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
65.719795
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
66.299164
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
66.299164
seq distance
False
chain
G
Charge relay system
position
7
score
50.0
distance
66.353775
seq distance
False
chain
K
Charge relay system
position
7
score
50.0
distance
66.353775
seq distance
False
chain
K
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
66.926
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
66.926
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
66.97123
seq distance
False
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
66.97123
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
67.028114
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
67.028114
seq distance
False
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
67.36942
seq distance
False
chain
F
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
67.36942
seq distance
False
chain
F
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
67.38673
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
67.38673
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
67.549515
seq distance
False
chain
K
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
67.549515
seq distance
False
chain
K
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
67.564476
seq distance
False
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
67.564476
seq distance
False
chain
G
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
67.90062
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
67.90062
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
68.364174
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
68.364174
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
68.39822
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
68.39822
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
68.39822
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
68.39822
seq distance
False
chain
G
Charge relay system
position
402
score
100.0
distance
68.457886
seq distance
False
chain
C
Charge relay system
position
402
score
100.0
distance
68.457886
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
347
score
100.0
distance
69.06497
seq distance
False
chain
G
Phosphoserine; by FAM20C
position
347
score
100.0
distance
69.06497
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
69.12827
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
69.12827
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
69.17229
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
69.17229
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
69.2998
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
69.2998
seq distance
False
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
69.38229
seq distance
False
chain
G
4-carboxyglutamate
position
349
score
50.0
distance
69.38229
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
69.744545
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
69.744545
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
69.89768
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
69.89768
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
70.10838
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
70.10838
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
70.277374
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
70.277374
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
70.70768
seq distance
False
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
70.70768
seq distance
False
chain
G
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
71.114265
seq distance
False
chain
G
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
71.114265
seq distance
False
chain
G
Charge relay system
position
299
score
100.0
distance
71.24312
seq distance
False
chain
G
Charge relay system
position
299
score
100.0
distance
71.24312
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
71.25047
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
71.25047
seq distance
False
chain
C
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
72.12792
seq distance
False
chain
C
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
72.12792
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
72.13198
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
72.13198
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
72.341805
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
72.341805
seq distance
False
chain
C
Charge relay system
position
253
score
100.0
distance
72.341805
seq distance
False
chain
C
Charge relay system
position
253
score
100.0
distance
72.341805
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
72.4406
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
72.4406
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
72.4406
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
72.4406
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
72.77118
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
72.77118
seq distance
False
chain
G
Charge relay system
position
253
score
100.0
distance
72.77118
seq distance
False
chain
G
Charge relay system
position
253
score
100.0
distance
72.77118
seq distance
False
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
72.98403
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
72.98403
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
73.16245
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
73.16245
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
73.56513
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
73.56513
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
73.81691
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
73.81691
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
74.35092
seq distance
False
chain
G
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
74.35092
seq distance
False
chain
G
Charge relay system
position
402
score
100.0
distance
74.79064
seq distance
False
chain
G
Charge relay system
position
402
score
100.0
distance
74.79064
seq distance
False
chain
G
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
74.937584
seq distance
False
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
74.937584
seq distance
False
chain
G
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
74.937584
seq distance
False
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
74.937584
seq distance
False
chain
G
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
75.03846
seq distance
False
chain
G
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
75.03846
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
75.89048
seq distance
False
chain
K
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
75.89048
seq distance
False
chain
K
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
76.1084
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
76.1084
seq distance
False
chain
G
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
76.357475
seq distance
False
chain
G
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
76.357475
seq distance
False
chain
G
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
76.55374
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
76.55374
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
76.64173
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
76.64173
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
76.64173
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
76.64173
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
76.6846
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
76.6846
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
76.6846
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
76.6846
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
77.010254
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
77.010254
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
77.17484
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
77.17484
seq distance
False
chain
G
Charge relay system
position
299
score
100.0
distance
77.31161
seq distance
False
chain
C
Charge relay system
position
299
score
100.0
distance
77.31161
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
77.42858
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
77.42858
seq distance
False
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
77.55826
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
77.55826
seq distance
False
chain
C
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
77.888306
seq distance
False
chain
I
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
77.888306
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
77.92723
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
77.92723
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
77.92723
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
77.92723
seq distance
False
chain
G
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
78.04382
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
78.04382
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
78.10765
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
78.10765
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
78.22377
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
78.22377
seq distance
False
chain
G
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
78.378716
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
78.378716
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
78.60723
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
78.60723
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
79.20191
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
79.20191
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
79.53997
seq distance
False
chain
G
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
79.53997
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
79.783264
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
79.783264
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
79.838486
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
79.838486
seq distance
False
chain
D
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
80.15539
seq distance
False
chain
G
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
80.15539
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
80.3072
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
80.3072
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
81.018715
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
81.018715
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
81.27345
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
81.27345
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
81.58133
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
81.58133
seq distance
False
chain
G
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
81.871765
seq distance
False
chain
G
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
81.871765
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
81.967285
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
81.967285
seq distance
False
chain
G
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
81.984505
seq distance
False
chain
G
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
81.984505
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
82.06282
seq distance
False
chain
I
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
82.06282
seq distance
False
chain
I
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
82.94962
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
82.94962
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
83.88406
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
83.88406
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
84.131546
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
84.131546
seq distance
False
chain
C
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
84.311035
seq distance
False
chain
I
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
84.311035
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
84.67887
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
84.67887
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
85.29033
seq distance
False
chain
E
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
85.29033
seq distance
False
chain
E
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
85.53383
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
85.53383
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
85.56512
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
85.56512
seq distance
False
chain
G
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
86.13445
seq distance
False
chain
G
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
86.13445
seq distance
False
chain
G
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
86.257126
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
86.257126
seq distance
False
chain
C
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
86.32301
seq distance
False
chain
D
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
86.32301
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
86.85123
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
86.85123
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
87.13802
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
87.13802
seq distance
False
chain
G
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
87.1428
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
87.1428
seq distance
False
chain
C
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
87.17211
seq distance
False
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
87.17211
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
87.662056
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
87.662056
seq distance
False
chain
I
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
87.70926
seq distance
False
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
87.70926
seq distance
False
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
87.70926
seq distance
False
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
87.70926
seq distance
False
chain
D
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
89.41519
seq distance
False
chain
G
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
89.41519
seq distance
False
chain
G
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
89.448494
seq distance
False
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
89.448494
seq distance
False
chain
I
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
89.448494
seq distance
False
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
89.448494
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
89.473656
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
89.473656
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
89.646065
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
89.646065
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
89.68906
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
89.68906
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
89.81178
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
89.81178
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
90.2215
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
90.2215
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
90.73165
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
90.73165
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
90.90971
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
90.90971
seq distance
False
chain
I
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
90.93419
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
90.93419
seq distance
False
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
90.93419
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
90.93419
seq distance
False
chain
G
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
91.07125
seq distance
False
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
91.07125
seq distance
False
chain
C
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
91.07125
seq distance
False
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
91.07125
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
91.858345
seq distance
False
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
91.858345
seq distance
False
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
91.858345
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
91.858345
seq distance
False
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
91.858345
seq distance
False
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
91.858345
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
92.0
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
92.0
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
92.92557
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
92.92557
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
93.37567
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
93.37567
seq distance
False
chain
I
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
93.76323
seq distance
False
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
93.76323
seq distance
False
chain
D
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
93.92888
seq distance
False
chain
G
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
93.92888
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
93.98243
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
93.98243
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
94.43806
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
94.43806
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
95.67128
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
95.67128
seq distance
False
chain
G
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
97.083534
seq distance
False
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
97.083534
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
97.17831
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
97.17831
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
98.12698
seq distance
False
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
98.12698
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
98.12698
seq distance
False
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
98.12698
seq distance
False
chain
G
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
99.50009
seq distance
False
chain
I
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
99.50009
seq distance
False
chain
I

Details

Redox score
76.52
PDB code
6m3c
Structure name
hapc-h1573 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
2.04
Half-sphere exposure sum
61
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
162
Residue number B
175
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

EGF-like 1
begin
55
end
90
score
100.0
distance
2.7323623
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
100.0
distance
2.7323623
seq distance
0
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
2.835032
seq distance
0
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
2.835032
seq distance
0
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
6.798689
seq distance
2
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
6.798689
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.049427
seq distance
27
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.049427
seq distance
27
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.049427
seq distance
27
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.049427
seq distance
27
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.049427
seq distance
27
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.049427
seq distance
27
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
8.751714
seq distance
3
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
8.751714
seq distance
3
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
9.686533
seq distance
13
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
9.686533
seq distance
14
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
9.686533
seq distance
13
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
9.686533
seq distance
14
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
14.061285
seq distance
8
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
14.061285
seq distance
12
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
14.061285
seq distance
12
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
14.061285
seq distance
8
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
14.061285
seq distance
12
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
14.061285
seq distance
12
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
16.999662
seq distance
30
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
16.999662
seq distance
30
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
18.221972
seq distance
7
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
18.221972
seq distance
7
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
19.543936
seq distance
38
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
19.543936
seq distance
39
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
19.543936
seq distance
38
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
19.543936
seq distance
39
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
20.713501
seq distance
8
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
20.713501
seq distance
8
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
21.569706
seq distance
41
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
21.569706
seq distance
41
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
22.23792
seq distance
False
chain
H
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
22.23792
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
25.65591
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
25.65591
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
25.958477
seq distance
43
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
25.958477
seq distance
43
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
27.005552
seq distance
69
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
27.005552
seq distance
69
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
28.871489
seq distance
55
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
28.871489
seq distance
55
chain
L
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
28.970612
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
28.970612
seq distance
False
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.671862
seq distance
False
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.671862
seq distance
False
chain
H
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
31.89906
seq distance
False
chain
H
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
31.89906
seq distance
False
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
31.90255
seq distance
False
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
31.90255
seq distance
False
chain
H
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
32.403988
seq distance
57
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
32.403988
seq distance
57
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
32.403988
seq distance
57
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
32.403988
seq distance
57
chain
L
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.56929
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.56929
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.56929
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.56929
seq distance
False
chain
H
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
35.19544
seq distance
72
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
35.19544
seq distance
72
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
35.58994
seq distance
77
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
35.58994
seq distance
77
chain
L
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.316692
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.316692
seq distance
False
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.83999
seq distance
False
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.83999
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
38.123524
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
38.123524
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
38.56793
seq distance
75
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
38.56793
seq distance
75
chain
L
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.30866
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.30866
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
39.40515
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
39.40515
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.62758
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.62758
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.14992
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.14992
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
40.183163
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
40.183163
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
40.262005
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
40.262005
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
40.93557
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
40.93557
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
41.160423
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
41.160423
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.82823
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.82823
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
42.118057
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
42.118057
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
42.122623
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
42.122623
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
42.122623
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
42.122623
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
42.122623
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
42.122623
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
43.01894
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
43.01894
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
43.48707
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
43.48707
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
43.622536
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
43.622536
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
43.622536
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
43.622536
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
44.58673
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
44.58673
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
44.89926
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
44.89926
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.034966
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.034966
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.58901
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.58901
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
45.796314
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
45.796314
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
45.84052
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
45.84052
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
46.474262
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
46.474262
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
47.065212
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
47.065212
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
47.8136
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
47.8136
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
47.92713
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
47.92713
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
48.309254
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
48.309254
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
48.309254
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
48.309254
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
48.95321
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
48.95321
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
49.310127
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
49.310127
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
51.312687
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
51.312687
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
51.312687
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
51.312687
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.438953
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.438953
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
52.065113
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
52.065113
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
54.158176
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
54.158176
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
54.158176
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
54.158176
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.20718
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.20718
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
54.306324
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
54.306324
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.07571
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.07571
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
56.431496
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
56.431496
seq distance
False
chain
H

Details

Redox score
76.33
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
2.03
Half-sphere exposure sum
44
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
101 (Residue 59 in this structure)
Residue number B
106 (Residue 64 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

EGF-like 2
begin
94
end
134
score
100.0
distance
2.7873774
seq distance
0
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
2.7873774
seq distance
0
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
4.001891
seq distance
4
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
4.001891
seq distance
5
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
4.001891
seq distance
4
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
4.001891
seq distance
5
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
5.8536158
seq distance
4
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
5.8536158
seq distance
4
chain
L
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
7.48172
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
7.48172
seq distance
False
chain
C
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
7.48172
seq distance
False
chain
C
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
7.48172
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
8.554983
seq distance
10
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
8.554983
seq distance
10
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
8.801831
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
8.801831
seq distance
2
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
12.900525
seq distance
15
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
12.900525
seq distance
15
chain
L
EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
12.900525
seq distance
8
chain
L
EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
12.900525
seq distance
8
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
13.088445
seq distance
24
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
13.088445
seq distance
24
chain
L
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
13.093669
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
13.093669
seq distance
False
chain
C
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
13.610459
seq distance
12
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
13.610459
seq distance
12
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
13.610459
seq distance
12
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
13.610459
seq distance
12
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
14.611836
seq distance
16
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
14.611836
seq distance
16
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
15.924439
seq distance
7
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
15.924439
seq distance
7
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
15.924439
seq distance
7
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
15.924439
seq distance
7
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
15.924439
seq distance
7
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
15.924439
seq distance
7
chain
L
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
20.28946
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
20.28946
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
20.450394
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
20.450394
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
20.488306
seq distance
32
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
20.488306
seq distance
32
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
20.804111
seq distance
32
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
20.804111
seq distance
32
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
21.019794
seq distance
27
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
21.019794
seq distance
27
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
21.912878
seq distance
31
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
21.912878
seq distance
31
chain
L
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
21.942358
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
21.942358
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
22.145702
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
22.145702
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
22.356781
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
22.356781
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
22.596325
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
22.596325
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
22.936438
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
22.936438
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
23.369604
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
23.369604
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
23.996744
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
23.996744
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
24.218262
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
24.218262
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
24.287458
seq distance
34
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
24.287458
seq distance
34
chain
L
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
24.44999
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
24.44999
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
24.960617
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
24.960617
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
25.2428
seq distance
30
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
25.2428
seq distance
30
chain
L
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
25.76061
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
25.76061
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
25.76061
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
25.76061
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
27.648819
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
27.648819
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
27.673956
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
27.673956
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
28.88376
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
28.88376
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
29.261023
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
29.261023
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
29.277746
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
29.277746
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
29.5255
seq distance
22
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
29.5255
seq distance
22
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
29.5255
seq distance
22
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
29.5255
seq distance
22
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
29.5255
seq distance
22
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
29.5255
seq distance
22
chain
L
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
29.601793
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
29.601793
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
29.970194
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
29.970194
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
29.998476
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
29.998476
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
29.998476
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
29.998476
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
30.085758
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
30.085758
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
30.090952
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
30.090952
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
30.45643
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
30.45643
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
31.169151
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
31.169151
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
31.169151
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
31.169151
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
31.319435
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
31.319435
seq distance
False
chain
C
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
32.630615
seq distance
26
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
32.630615
seq distance
26
chain
L
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
32.725597
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
32.725597
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
32.74876
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
32.74876
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
34.047874
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
34.047874
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
34.11642
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
34.11642
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
34.1929
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
34.1929
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
34.625885
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
34.625885
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
34.625885
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
34.625885
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
34.625885
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
34.625885
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
35.126194
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
35.126194
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
35.126194
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
35.126194
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
36.318916
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
36.318916
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
37.519592
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
37.519592
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
37.83005
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
37.83005
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
39.265858
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
39.265858
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
43.482986
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
43.482986
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
45.24974
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
45.24974
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
45.295036
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
45.295036
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
45.295036
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
45.295036
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
45.73475
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
45.73475
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
51.786343
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
51.786343
seq distance
False
chain
C

Details

Redox score
75.83
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
2.03
Half-sphere exposure sum
72
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
140 (Residue 98 in this structure)
Residue number B
151 (Residue 109 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
2.7989037
seq distance
0
chain
H
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
2.7989037
seq distance
0
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
6.9050694
seq distance
49
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
6.9050694
seq distance
49
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
7.13328
seq distance
4
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
7.13328
seq distance
4
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
7.948843
seq distance
3
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
7.948843
seq distance
3
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
8.951283
seq distance
6
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
8.951283
seq distance
6
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
9.150947
seq distance
45
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
9.150947
seq distance
45
chain
H
Charge relay system
position
195
score
100.0
distance
10.08559
seq distance
4
chain
H
Charge relay system
position
195
score
100.0
distance
10.08559
seq distance
4
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
10.261121
seq distance
4
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
10.261121
seq distance
4
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
11.152176
seq distance
7
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
11.152176
seq distance
7
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
13.054711
seq distance
33
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
13.054711
seq distance
33
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
13.116912
seq distance
52
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
13.116912
seq distance
52
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
13.957523
seq distance
8
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
13.957523
seq distance
8
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
13.957523
seq distance
8
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
13.957523
seq distance
8
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
14.93068
seq distance
39
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
14.93068
seq distance
39
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
15.374851
seq distance
134
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
15.374851
seq distance
134
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
15.374851
seq distance
134
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
15.374851
seq distance
134
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
16.252039
seq distance
9
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
16.252039
seq distance
9
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
16.71654
seq distance
147
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
16.71654
seq distance
147
chain
H
Charge relay system
position
102
score
100.0
distance
17.128119
seq distance
89
chain
H
Charge relay system
position
102
score
100.0
distance
17.128119
seq distance
89
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
17.325827
seq distance
9
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
17.325827
seq distance
9
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
17.588491
seq distance
11
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
17.588491
seq distance
11
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
18.09318
seq distance
29
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
18.09318
seq distance
29
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
18.283804
seq distance
42
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
18.283804
seq distance
42
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
18.49931
seq distance
91
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
18.49931
seq distance
91
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
18.510397
seq distance
161
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
18.510397
seq distance
161
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
18.609018
seq distance
94
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
18.609018
seq distance
94
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
19.803123
seq distance
117
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
19.803123
seq distance
117
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
19.803123
seq distance
117
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
19.803123
seq distance
117
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
19.996456
seq distance
90
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
19.996456
seq distance
90
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
20.93503
seq distance
27
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
20.93503
seq distance
27
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
20.973572
seq distance
164
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
20.973572
seq distance
164
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
21.172377
seq distance
87
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
21.172377
seq distance
87
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
21.172377
seq distance
87
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
21.172377
seq distance
87
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
22.726534
seq distance
58
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
22.726534
seq distance
58
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
23.233603
seq distance
123
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
23.233603
seq distance
123
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
23.237265
seq distance
116
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
23.237265
seq distance
116
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
23.29471
seq distance
167
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
23.29471
seq distance
167
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
23.29471
seq distance
167
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
23.29471
seq distance
167
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
23.29471
seq distance
167
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
23.29471
seq distance
167
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
25.499971
seq distance
144
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
25.499971
seq distance
144
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
25.607292
seq distance
14
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
25.607292
seq distance
14
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
26.17407
seq distance
71
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
26.17407
seq distance
71
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
26.82361
seq distance
99
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
26.82361
seq distance
99
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
27.281065
seq distance
107
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
27.281065
seq distance
107
chain
H
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
28.08648
seq distance
67
chain
H
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
28.08648
seq distance
67
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
28.400192
seq distance
18
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
28.400192
seq distance
18
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
28.80843
seq distance
143
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
28.80843
seq distance
143
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
29.541563
seq distance
17
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
29.541563
seq distance
17
chain
H
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
29.58455
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
29.58455
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
30.114202
seq distance
79
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
30.114202
seq distance
79
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
31.608032
seq distance
76
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
31.608032
seq distance
76
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
31.608032
seq distance
76
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
31.608032
seq distance
76
chain
H
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
31.843227
seq distance
64
chain
H
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
31.843227
seq distance
64
chain
H
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
33.63389
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
33.63389
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
33.772045
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
33.772045
seq distance
False
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
33.772045
seq distance
False
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
33.772045
seq distance
False
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
33.87435
seq distance
False
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
33.87435
seq distance
False
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
33.87435
seq distance
False
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
33.87435
seq distance
False
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
35.427837
seq distance
False
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
35.427837
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
37.985596
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
37.985596
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
38.631687
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
38.631687
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
39.067177
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
39.067177
seq distance
False
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
39.089188
seq distance
False
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
39.089188
seq distance
False
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
40.033764
seq distance
False
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
40.033764
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
41.22348
seq distance
False
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
41.22348
seq distance
False
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
41.22348
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
41.22348
seq distance
False
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
41.22348
seq distance
False
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
41.22348
seq distance
False
chain
L
EGF-like 1
begin
55
end
90
score
100.0
distance
42.60399
seq distance
False
chain
L
EGF-like 1
begin
55
end
90
score
100.0
distance
42.60399
seq distance
False
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
46.038017
seq distance
False
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
46.038017
seq distance
False
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
49.286705
seq distance
False
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
49.286705
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
49.92168
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
49.92168
seq distance
False
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
50.421124
seq distance
False
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
50.421124
seq distance
False
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
52.34983
seq distance
False
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
52.34983
seq distance
False
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
54.68858
seq distance
False
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
54.68858
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
54.68858
seq distance
False
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
54.68858
seq distance
False
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
54.68858
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
54.68858
seq distance
False
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
60.25169
seq distance
False
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
60.25169
seq distance
False
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
61.07344
seq distance
False
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
61.07344
seq distance
False
chain
L

Details

Redox score
75.41
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
1.99
Half-sphere exposure sum
71
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
398 (Residue 191 in this structure)
Residue number B
426 (Residue 220 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
2.8124237
seq distance
0
chain
C
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
2.8124237
seq distance
0
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
6.028898
seq distance
46
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
6.028898
seq distance
46
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
6.2029514
seq distance
2
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
6.2029514
seq distance
2
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
6.2300615
seq distance
1
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
6.2300615
seq distance
1
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
6.2300615
seq distance
1
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
6.2300615
seq distance
1
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
7.523051
seq distance
4
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
7.523051
seq distance
4
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
8.479125
seq distance
6
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
8.479125
seq distance
6
chain
C
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
8.494716
seq distance
36
chain
C
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
8.494716
seq distance
36
chain
C
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
9.050406
seq distance
49
chain
C
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
9.050406
seq distance
49
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
10.710758
seq distance
33
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
10.710758
seq distance
33
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
11.09241
seq distance
31
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
11.09241
seq distance
31
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
12.148232
seq distance
76
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
12.148232
seq distance
76
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
12.821549
seq distance
39
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
12.821549
seq distance
39
chain
C
Charge relay system
position
299
score
100.0
distance
13.152328
seq distance
74
chain
C
Charge relay system
position
299
score
100.0
distance
13.152328
seq distance
74
chain
C
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
13.429943
seq distance
39
chain
C
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
13.429943
seq distance
39
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
13.436941
seq distance
75
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
13.436941
seq distance
75
chain
C
Charge relay system
position
402
score
100.0
distance
14.608271
seq distance
15
chain
C
Charge relay system
position
402
score
100.0
distance
14.608271
seq distance
15
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
15.1775
seq distance
7
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
15.1775
seq distance
7
chain
C
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
15.22947
seq distance
46
chain
C
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
15.22947
seq distance
46
chain
C
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
15.364901
seq distance
5
chain
C
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
15.364901
seq distance
5
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
16.158669
seq distance
14
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
16.158669
seq distance
14
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
16.246233
seq distance
10
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
16.246233
seq distance
10
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
17.141668
seq distance
120
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
17.141668
seq distance
120
chain
C
Charge relay system
position
253
score
100.0
distance
17.141668
seq distance
120
chain
C
Charge relay system
position
253
score
100.0
distance
17.141668
seq distance
120
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
17.21293
seq distance
79
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
17.21293
seq distance
79
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
17.251434
seq distance
54
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
17.251434
seq distance
54
chain
C
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
17.464476
seq distance
45
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
17.464476
seq distance
45
chain
C
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
17.464476
seq distance
45
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
17.464476
seq distance
45
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
17.490562
seq distance
33
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
17.490562
seq distance
33
chain
C
Phosphoserine; by FAM20C
position
347
score
100.0
distance
18.55812
seq distance
26
chain
C
Phosphoserine; by FAM20C
position
347
score
100.0
distance
18.55812
seq distance
26
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
19.150106
seq distance
72
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
19.150106
seq distance
72
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
19.150106
seq distance
72
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
19.150106
seq distance
72
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
19.263126
seq distance
30
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
19.263126
seq distance
30
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
19.426456
seq distance
133
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
19.426456
seq distance
133
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
20.278511
seq distance
52
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
20.278511
seq distance
52
chain
C
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
20.678879
seq distance
49
chain
C
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
20.678879
seq distance
49
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
21.970783
seq distance
84
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
21.970783
seq distance
84
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
22.073345
seq distance
57
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
22.073345
seq distance
57
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
22.267744
seq distance
147
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
22.267744
seq distance
147
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
22.272854
seq distance
24
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
22.272854
seq distance
24
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
22.423029
seq distance
58
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
22.423029
seq distance
58
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
22.982883
seq distance
130
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
22.982883
seq distance
130
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
23.718206
seq distance
150
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
23.718206
seq distance
150
chain
C
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
24.37449
seq distance
False
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
24.37449
seq distance
False
chain
D
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
24.37449
seq distance
False
chain
D
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
24.37449
seq distance
False
chain
D
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
25.380377
seq distance
16
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
25.380377
seq distance
16
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
25.617918
seq distance
56
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
25.617918
seq distance
56
chain
C
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
25.764572
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
25.764572
seq distance
False
chain
D
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
26.197304
seq distance
False
chain
F
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
26.197304
seq distance
False
chain
F
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
26.669462
seq distance
129
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
26.669462
seq distance
129
chain
C
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
27.082645
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
27.082645
seq distance
False
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
27.402777
seq distance
False
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
27.402777
seq distance
False
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
27.402777
seq distance
False
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
27.402777
seq distance
False
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
27.991768
seq distance
False
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
27.991768
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
28.218443
seq distance
108
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
28.218443
seq distance
108
chain
C
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
28.594442
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
28.594442
seq distance
False
chain
D
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
29.285732
seq distance
153
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
29.285732
seq distance
153
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
29.285732
seq distance
153
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
29.285732
seq distance
153
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
29.285732
seq distance
153
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
29.285732
seq distance
153
chain
C
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
30.242216
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
30.242216
seq distance
False
chain
D
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
31.476677
seq distance
False
chain
E
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
31.476677
seq distance
False
chain
E
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
31.877851
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
31.877851
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
32.753605
seq distance
64
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
32.753605
seq distance
64
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
32.807095
seq distance
102
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
32.807095
seq distance
102
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
32.807095
seq distance
102
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
32.807095
seq distance
102
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
32.876358
seq distance
92
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
32.876358
seq distance
92
chain
C
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
33.105988
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
33.105988
seq distance
False
chain
D
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
33.96472
seq distance
False
chain
F
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
33.96472
seq distance
False
chain
F
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
34.18995
seq distance
61
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
34.18995
seq distance
61
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
34.18995
seq distance
61
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
34.18995
seq distance
61
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
34.625137
seq distance
101
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
34.625137
seq distance
101
chain
C
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
36.339985
seq distance
False
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
36.339985
seq distance
False
chain
D
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
39.544178
seq distance
False
chain
L
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
39.544178
seq distance
False
chain
L
Charge relay system
position
7
score
50.0
distance
42.590153
seq distance
False
chain
F
Charge relay system
position
7
score
50.0
distance
42.590153
seq distance
False
chain
F
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
49.440052
seq distance
False
chain
A
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
49.440052
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
54.09876
seq distance
False
chain
F
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
54.09876
seq distance
False
chain
F
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
55.001755
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
55.001755
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
57.655895
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
57.655895
seq distance
False
chain
H
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
59.476185
seq distance
False
chain
A
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
59.476185
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
60.144917
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
60.144917
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
60.90799
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
60.90799
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
61.565395
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
61.565395
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
61.737404
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
61.737404
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
61.737404
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
61.737404
seq distance
False
chain
A
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
62.427364
seq distance
False
chain
B
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
62.427364
seq distance
False
chain
B
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
62.489468
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
62.489468
seq distance
False
chain
A
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
62.563343
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
62.563343
seq distance
False
chain
A
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
62.563343
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
62.563343
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
62.58663
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
62.58663
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
62.624626
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
62.624626
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
62.77681
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
62.77681
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
63.08275
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
63.08275
seq distance
False
chain
A
Charge relay system
position
7
score
50.0
distance
64.91046
seq distance
False
chain
H
Charge relay system
position
7
score
50.0
distance
64.91046
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
64.97595
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
64.97595
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
65.43718
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
65.43718
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
65.65764
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
65.65764
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
65.70737
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
65.70737
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
65.72599
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
65.72599
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
66.23716
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
66.23716
seq distance
False
chain
A
Charge relay system
position
299
score
100.0
distance
67.51513
seq distance
False
chain
A
Charge relay system
position
299
score
100.0
distance
67.51513
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
67.98342
seq distance
False
chain
B
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
67.98342
seq distance
False
chain
B
Phosphoserine; by FAM20C
position
347
score
100.0
distance
68.08551
seq distance
False
chain
A
Phosphoserine; by FAM20C
position
347
score
100.0
distance
68.08551
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
68.195885
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
68.195885
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
68.824875
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
68.824875
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
68.92256
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
68.92256
seq distance
False
chain
A
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
68.93513
seq distance
False
chain
B
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
68.93513
seq distance
False
chain
B
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
70.816246
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
70.816246
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
71.15625
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
71.15625
seq distance
False
chain
A
Charge relay system
position
253
score
100.0
distance
71.15625
seq distance
False
chain
A
Charge relay system
position
253
score
100.0
distance
71.15625
seq distance
False
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
71.24748
seq distance
False
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
71.24748
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
71.590385
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
71.590385
seq distance
False
chain
A
Charge relay system
position
402
score
100.0
distance
71.91848
seq distance
False
chain
A
Charge relay system
position
402
score
100.0
distance
71.91848
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
72.110275
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
72.110275
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
72.574425
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
72.574425
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
73.455956
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
73.455956
seq distance
False
chain
B
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
73.473724
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
73.473724
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
74.13914
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
74.13914
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
74.13914
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
74.13914
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
74.644
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
74.644
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
74.95202
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
74.95202
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
75.03285
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
75.03285
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
75.24088
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
75.24088
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
77.317375
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
77.317375
seq distance
False
chain
B
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
77.373795
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
77.373795
seq distance
False
chain
A
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
78.83978
seq distance
False
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
78.83978
seq distance
False
chain
B
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
78.83978
seq distance
False
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
78.83978
seq distance
False
chain
B
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
79.34828
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
79.34828
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
80.395454
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
80.395454
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
80.80427
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
80.80427
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
80.85399
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
80.85399
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
80.93486
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
80.93486
seq distance
False
chain
B
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
81.12379
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
81.12379
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
82.05856
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
82.05856
seq distance
False
chain
B
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
82.26721
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
82.26721
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
82.62363
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
82.62363
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
86.11664
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
86.11664
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
86.11664
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
86.11664
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
86.11664
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
86.11664
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
86.57156
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
86.57156
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
88.51832
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
88.51832
seq distance
False
chain
B
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
88.82998
seq distance
False
chain
B
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
88.82998
seq distance
False
chain
B
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
89.397064
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
89.397064
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
89.397064
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
89.397064
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
89.40292
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
89.40292
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
90.08643
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
90.08643
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
91.40149
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
91.40149
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
91.40149
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
91.40149
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
91.74046
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
91.74046
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
97.91891
seq distance
False
chain
J
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
97.91891
seq distance
False
chain
J
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
104.46086
seq distance
False
chain
G
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
104.46086
seq distance
False
chain
G
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
107.54645
seq distance
False
chain
G
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
107.54645
seq distance
False
chain
G
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
108.60205
seq distance
False
chain
I
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
108.60205
seq distance
False
chain
I
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
110.73884
seq distance
False
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
110.73884
seq distance
False
chain
G
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
111.93058
seq distance
False
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
111.93058
seq distance
False
chain
G
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
111.93058
seq distance
False
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
111.93058
seq distance
False
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
112.00622
seq distance
False
chain
K
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
112.00622
seq distance
False
chain
K
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
112.07203
seq distance
False
chain
G
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
112.07203
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
113.08644
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
113.08644
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
113.553535
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
113.553535
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
114.405106
seq distance
False
chain
I
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
114.405106
seq distance
False
chain
I
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
114.405106
seq distance
False
chain
I
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
114.405106
seq distance
False
chain
I
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
114.91968
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
114.91968
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
114.91968
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
114.91968
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
115.60582
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
115.60582
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
115.80899
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
115.80899
seq distance
False
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
117.39258
seq distance
False
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
117.39258
seq distance
False
chain
G
Charge relay system
position
7
score
50.0
distance
117.438774
seq distance
False
chain
K
Charge relay system
position
7
score
50.0
distance
117.438774
seq distance
False
chain
K
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
118.673325
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
118.673325
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
119.04319
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
119.04319
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
119.352165
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
119.352165
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
119.71145
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
119.71145
seq distance
False
chain
I
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
120.3189
seq distance
False
chain
G
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
120.3189
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
120.48841
seq distance
False
chain
K
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
120.48841
seq distance
False
chain
K
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
121.21372
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
121.21372
seq distance
False
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
121.46888
seq distance
False
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
121.46888
seq distance
False
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
121.52547
seq distance
False
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
121.52547
seq distance
False
chain
G
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
121.78609
seq distance
False
chain
G
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
121.78609
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
122.382935
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
122.382935
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
122.64807
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
122.64807
seq distance
False
chain
I
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
122.65185
seq distance
False
chain
G
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
122.65185
seq distance
False
chain
G
Charge relay system
position
299
score
100.0
distance
123.53683
seq distance
False
chain
G
Charge relay system
position
299
score
100.0
distance
123.53683
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
123.88881
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
123.88881
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
124.02897
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
124.02897
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
124.402985
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
124.402985
seq distance
False
chain
I
Phosphoserine; by FAM20C
position
347
score
100.0
distance
124.48622
seq distance
False
chain
G
Phosphoserine; by FAM20C
position
347
score
100.0
distance
124.48622
seq distance
False
chain
G
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
125.90423
seq distance
False
chain
G
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
125.90423
seq distance
False
chain
G
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
126.74758
seq distance
False
chain
G
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
126.74758
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
127.702354
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
127.702354
seq distance
False
chain
I
Charge relay system
position
402
score
100.0
distance
127.722
seq distance
False
chain
G
Charge relay system
position
402
score
100.0
distance
127.722
seq distance
False
chain
G
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
128.17554
seq distance
False
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
128.17554
seq distance
False
chain
I
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
128.17554
seq distance
False
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
128.17554
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
128.17656
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
128.17656
seq distance
False
chain
G
Charge relay system
position
253
score
100.0
distance
128.17656
seq distance
False
chain
G
Charge relay system
position
253
score
100.0
distance
128.17656
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
128.32652
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
128.32652
seq distance
False
chain
G
4-carboxyglutamate
position
349
score
50.0
distance
128.35893
seq distance
False
chain
G
4-carboxyglutamate
position
349
score
50.0
distance
128.35893
seq distance
False
chain
G
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
128.38965
seq distance
False
chain
G
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
128.38965
seq distance
False
chain
G
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
128.93007
seq distance
False
chain
G
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
128.93007
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
129.62361
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
129.62361
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
129.62361
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
129.62361
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
130.80342
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
130.80342
seq distance
False
chain
G
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
132.01688
seq distance
False
chain
G
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
132.01688
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
132.13852
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
132.13852
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
132.52142
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
132.52142
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
132.58403
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
132.58403
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
133.83351
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
133.83351
seq distance
False
chain
G
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
134.05957
seq distance
False
chain
G
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
134.05957
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
135.048
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
135.048
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
135.21475
seq distance
False
chain
K
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
135.21475
seq distance
False
chain
K
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
135.28598
seq distance
False
chain
G
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
135.28598
seq distance
False
chain
G
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
136.58662
seq distance
False
chain
I
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
136.58662
seq distance
False
chain
I
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
138.0848
seq distance
False
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
138.0848
seq distance
False
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
138.0848
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
138.0848
seq distance
False
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
138.0848
seq distance
False
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
138.0848
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
138.55627
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
138.55627
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
140.1991
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
140.1991
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
142.6838
seq distance
False
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
142.6838
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
142.6838
seq distance
False
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
142.6838
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
143.35007
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
143.35007
seq distance
False
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
144.19307
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
144.19307
seq distance
False
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
144.19307
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
144.19307
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
145.07526
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
145.07526
seq distance
False
chain
G
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
145.93794
seq distance
False
chain
G
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
145.93794
seq distance
False
chain
G

Details

Redox score
75.14
PDB code
6m3c
Structure name
hapc-h1573 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
2.03
Half-sphere exposure sum
80
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
373
Residue number B
387
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
2.574503
seq distance
0
chain
H
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
2.574503
seq distance
0
chain
H
Charge relay system
position
195
score
100.0
distance
4.6244917
seq distance
137
chain
H
Charge relay system
position
195
score
100.0
distance
4.6244917
seq distance
137
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
5.1630774
seq distance
1
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
5.1630774
seq distance
1
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
5.1630774
seq distance
1
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
5.1630774
seq distance
1
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
6.6201463
seq distance
136
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
6.6201463
seq distance
136
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
7.599507
seq distance
2
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
7.599507
seq distance
2
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
8.236016
seq distance
155
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
8.236016
seq distance
155
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
8.766546
seq distance
46
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
8.766546
seq distance
46
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
8.766546
seq distance
46
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
8.766546
seq distance
46
chain
H
Charge relay system
position
102
score
100.0
distance
8.882753
seq distance
44
chain
H
Charge relay system
position
102
score
100.0
distance
8.882753
seq distance
44
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
9.366012
seq distance
84
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
9.366012
seq distance
84
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
11.65573
seq distance
171
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
11.65573
seq distance
171
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
12.708628
seq distance
43
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
12.708628
seq distance
43
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
12.870595
seq distance
12
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
12.870595
seq distance
12
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
13.149149
seq distance
153
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
13.149149
seq distance
153
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
13.237167
seq distance
81
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
13.237167
seq distance
81
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
13.369104
seq distance
158
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
13.369104
seq distance
158
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
13.496257
seq distance
42
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
13.496257
seq distance
42
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
15.110555
seq distance
168
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
15.110555
seq distance
168
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
15.183433
seq distance
39
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
15.183433
seq distance
39
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
15.379156
seq distance
10
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
15.379156
seq distance
10
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
15.530415
seq distance
122
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
15.530415
seq distance
122
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
16.008492
seq distance
26
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
16.008492
seq distance
26
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
16.118826
seq distance
5
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
16.118826
seq distance
5
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
16.181046
seq distance
34
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
16.181046
seq distance
34
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
17.087776
seq distance
176
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
17.087776
seq distance
176
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
17.645031
seq distance
180
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
17.645031
seq distance
180
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
17.976976
seq distance
15
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
17.976976
seq distance
15
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
18.01428
seq distance
100
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
18.01428
seq distance
100
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
18.34968
seq distance
125
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
18.34968
seq distance
125
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
18.34968
seq distance
125
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
18.34968
seq distance
125
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
18.591637
seq distance
62
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
18.591637
seq distance
62
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
18.711388
seq distance
16
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
18.711388
seq distance
16
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
18.711388
seq distance
16
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
18.711388
seq distance
16
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
18.780212
seq distance
6
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
18.780212
seq distance
6
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
19.11113
seq distance
179
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
19.11113
seq distance
179
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
19.239649
seq distance
94
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
19.239649
seq distance
94
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
20.109346
seq distance
88
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
20.109346
seq distance
88
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
20.499542
seq distance
54
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
20.499542
seq distance
54
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
20.89402
seq distance
104
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
20.89402
seq distance
104
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
21.15419
seq distance
17
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
21.15419
seq distance
17
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
21.288486
seq distance
129
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
21.288486
seq distance
129
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
21.846733
seq distance
18
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
21.846733
seq distance
18
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
21.846733
seq distance
18
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
21.846733
seq distance
18
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
21.846733
seq distance
18
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
21.846733
seq distance
18
chain
H
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
22.0544
seq distance
66
chain
H
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
22.0544
seq distance
66
chain
H
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
22.939426
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
22.939426
seq distance
False
chain
L
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
24.457548
seq distance
106
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
24.457548
seq distance
106
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
25.15445
seq distance
57
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
25.15445
seq distance
57
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
25.15445
seq distance
57
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
25.15445
seq distance
57
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
26.236628
seq distance
75
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
26.236628
seq distance
75
chain
H
EGF-like 2
begin
94
end
134
score
100.0
distance
26.700129
seq distance
False
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
26.700129
seq distance
False
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
26.763315
seq distance
False
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
26.763315
seq distance
False
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
26.763315
seq distance
False
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
26.763315
seq distance
False
chain
L
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
26.99387
seq distance
91
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
26.99387
seq distance
91
chain
H
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
27.028864
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
27.028864
seq distance
False
chain
L
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
27.308664
seq distance
69
chain
H
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
27.308664
seq distance
69
chain
H
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
29.14803
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
29.14803
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
32.811493
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
32.811493
seq distance
False
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
33.06939
seq distance
False
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
33.06939
seq distance
False
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
33.145885
seq distance
False
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
33.145885
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
33.40114
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
33.40114
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
34.37004
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
34.37004
seq distance
False
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
36.337
seq distance
False
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
36.337
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
42.178253
seq distance
False
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
42.178253
seq distance
False
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
42.178253
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
42.178253
seq distance
False
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
42.178253
seq distance
False
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
42.178253
seq distance
False
chain
L
EGF-like 1
begin
55
end
90
score
100.0
distance
43.09708
seq distance
False
chain
L
EGF-like 1
begin
55
end
90
score
100.0
distance
43.09708
seq distance
False
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
44.89628
seq distance
False
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
44.89628
seq distance
False
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
47.69046
seq distance
False
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
47.69046
seq distance
False
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
50.978287
seq distance
False
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
50.978287
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
51.777634
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
51.777634
seq distance
False
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
52.38295
seq distance
False
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
52.38295
seq distance
False
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
55.267544
seq distance
False
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
55.267544
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
55.267544
seq distance
False
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
55.267544
seq distance
False
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
55.267544
seq distance
False
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
55.267544
seq distance
False
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
59.686234
seq distance
False
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
59.686234
seq distance
False
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
60.457092
seq distance
False
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
60.457092
seq distance
False
chain
L

Details

Redox score
74.89
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
2
Half-sphere exposure sum
87
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
238 (Residue 42 in this structure)
Residue number B
254 (Residue 58 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

EGF-like 1
begin
55
end
90
score
100.0
distance
2.714852
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
100.0
distance
2.714852
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
2.8275514
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
2.8275514
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
2.8275514
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
2.8275514
seq distance
0
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
4.1727505
seq distance
11
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
4.1727505
seq distance
11
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
4.9140034
seq distance
12
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
4.9140034
seq distance
12
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.5487614
seq distance
14
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.5487614
seq distance
14
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
7.3626833
seq distance
2
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
7.3626833
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
7.3626833
seq distance
2
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
7.3626833
seq distance
2
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
7.3626833
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
7.3626833
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
11.238107
seq distance
7
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
11.238107
seq distance
7
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
13.540473
seq distance
6
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
13.540473
seq distance
6
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
14.226555
seq distance
5
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
14.226555
seq distance
5
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
16.334274
seq distance
13
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
16.334274
seq distance
14
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
16.334274
seq distance
13
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
16.334274
seq distance
14
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
17.716223
seq distance
16
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
17.716223
seq distance
16
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
20.0687
seq distance
False
chain
H
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
20.0687
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
22.494287
seq distance
44
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
22.494287
seq distance
44
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
22.656708
seq distance
18
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
22.656708
seq distance
18
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
24.474903
seq distance
30
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
24.474903
seq distance
30
chain
L
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
26.936178
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
26.936178
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
27.350496
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
27.350496
seq distance
False
chain
H
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
28.71428
seq distance
32
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
28.71428
seq distance
32
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
28.71428
seq distance
32
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
28.71428
seq distance
32
chain
L
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
29.58346
seq distance
False
chain
H
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
29.58346
seq distance
False
chain
H
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
30.50165
seq distance
47
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
30.50165
seq distance
47
chain
L
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
31.769258
seq distance
False
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
31.769258
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
32.547443
seq distance
52
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
32.547443
seq distance
52
chain
L
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
33.624836
seq distance
False
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
33.624836
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
35.00793
seq distance
50
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
35.00793
seq distance
50
chain
L
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
35.855236
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
35.855236
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
35.855236
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
35.855236
seq distance
False
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.27175
seq distance
False
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.27175
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
36.820827
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
36.820827
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
36.83682
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
36.83682
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
37.264908
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
37.264908
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
38.673664
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
38.673664
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.20132
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.20132
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
39.2441
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
39.2441
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.820503
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.820503
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
39.954357
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
39.954357
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
40.027527
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
40.027527
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
40.604774
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
40.604774
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
40.604774
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
40.604774
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
40.787422
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
40.787422
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
41.018867
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
41.018867
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
41.42987
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
41.42987
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.801582
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.801582
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
42.26228
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
42.26228
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
42.54154
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
42.54154
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
43.693184
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
43.693184
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
45.184864
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
45.184864
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.6691
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.6691
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
45.69066
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
45.69066
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
45.917435
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
45.917435
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
45.961224
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
45.961224
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
45.974167
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
45.974167
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
46.219593
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
46.219593
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
46.857414
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
46.857414
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
46.857414
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
46.857414
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
46.964115
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
46.964115
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
48.14708
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
48.14708
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
49.84912
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
49.84912
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
50.606457
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
50.606457
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
50.841156
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
50.841156
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
50.841156
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
50.841156
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
53.22761
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
53.22761
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
53.46736
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
53.46736
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
53.688847
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
53.688847
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
53.688847
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
53.688847
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
54.14887
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
54.14887
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.48963
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.48963
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
56.820526
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
56.820526
seq distance
False
chain
H

Details

Redox score
73.26
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
4.27
Half-sphere exposure sum
56
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
120 (Residue 78 in this structure)
Residue number B
131 (Residue 89 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

EGF-like 1
begin
55
end
90
score
100.0
distance
2.77755
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
100.0
distance
2.77755
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
3.780042
seq distance
8
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
3.780042
seq distance
9
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
3.780042
seq distance
8
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
3.780042
seq distance
9
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
4.285452
seq distance
3
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
4.285452
seq distance
7
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
4.285452
seq distance
7
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
4.285452
seq distance
3
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
4.285452
seq distance
7
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
4.285452
seq distance
7
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
4.6754613
seq distance
2
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
4.6754613
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.46734
seq distance
1
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.46734
seq distance
1
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
6.8292723
seq distance
3
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
6.8292723
seq distance
3
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
7.334364
seq distance
2
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
7.334364
seq distance
2
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
9.56737
seq distance
3
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
9.56737
seq distance
3
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
12.174682
seq distance
22
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
12.174682
seq distance
22
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
12.174682
seq distance
22
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
12.174682
seq distance
22
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
12.174682
seq distance
22
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
12.174682
seq distance
22
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
18.608398
seq distance
25
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
18.608398
seq distance
25
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
20.84228
seq distance
33
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
20.84228
seq distance
34
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
20.84228
seq distance
33
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
20.84228
seq distance
34
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
21.968048
seq distance
36
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
21.968048
seq distance
36
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
23.74013
seq distance
False
chain
H
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
23.74013
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
26.016617
seq distance
64
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
26.016617
seq distance
64
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
26.801653
seq distance
38
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
26.801653
seq distance
38
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
28.526636
seq distance
50
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
28.526636
seq distance
50
chain
L
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
31.115509
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
31.115509
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
31.478907
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
31.478907
seq distance
False
chain
H
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
32.678764
seq distance
52
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
32.678764
seq distance
52
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
32.678764
seq distance
52
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
32.678764
seq distance
52
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
33.555904
seq distance
67
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
33.555904
seq distance
67
chain
L
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
33.89548
seq distance
False
chain
H
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
33.89548
seq distance
False
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
35.674427
seq distance
False
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
35.674427
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
36.14621
seq distance
72
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
36.14621
seq distance
72
chain
L
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
37.591705
seq distance
False
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
37.591705
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
38.120483
seq distance
70
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
38.120483
seq distance
70
chain
L
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
39.667603
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
39.667603
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
39.667603
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
39.667603
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
40.08905
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
40.08905
seq distance
False
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
40.42166
seq distance
False
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
40.42166
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
40.488075
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
40.488075
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
40.50601
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
40.50601
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
42.616486
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
42.616486
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
42.669163
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
42.669163
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
43.573708
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
43.573708
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
43.573708
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
43.573708
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
43.703255
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
43.703255
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
43.73306
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
43.73306
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
43.73306
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
43.73306
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
43.73306
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
43.73306
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
43.89061
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
43.89061
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
44.10978
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
44.10978
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
44.196617
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
44.196617
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
44.34841
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
44.34841
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
45.22618
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
45.22618
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
45.36362
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
45.36362
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
45.6361
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
45.6361
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
45.75756
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
45.75756
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
46.703835
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
46.703835
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
47.560493
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
47.560493
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
49.368713
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
49.368713
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
49.385376
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
49.385376
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
49.462364
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
49.462364
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
49.580643
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
49.580643
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
49.593502
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
49.593502
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
50.084557
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
50.084557
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
50.21092
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
50.21092
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
51.111057
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
51.111057
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
51.111057
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
51.111057
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
51.318085
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
51.318085
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
51.610313
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
51.610313
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
52.63311
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
52.63311
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
55.005013
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
55.005013
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
55.005013
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
55.005013
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
55.073578
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
55.073578
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
56.246857
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
56.246857
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
56.259216
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
56.259216
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
56.60802
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
56.60802
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
56.60802
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
56.60802
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
57.90722
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
57.90722
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
58.77196
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
58.77196
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
59.30165
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
59.30165
seq distance
False
chain
H

Details

Redox score
73.07
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
4.32
Half-sphere exposure sum
58
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
105 (Residue 63 in this structure)
Residue number B
111 (Residue 69 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

EGF-like 2
begin
94
end
134
score
100.0
distance
2.6695042
seq distance
0
chain
D
EGF-like 2
begin
94
end
134
score
100.0
distance
2.6695042
seq distance
0
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
2.892112
seq distance
0
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
2.892112
seq distance
0
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
4.826575
seq distance
2
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
4.826575
seq distance
2
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
4.826575
seq distance
2
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
4.826575
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
6.5773854
seq distance
10
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
6.5773854
seq distance
10
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
6.846142
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
6.846142
seq distance
2
chain
D
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
8.012233
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
8.012233
seq distance
False
chain
A
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
8.012233
seq distance
False
chain
A
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
8.012233
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
9.601801
seq distance
24
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
9.601801
seq distance
24
chain
D
EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
11.525143
seq distance
15
chain
D
EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
11.525143
seq distance
15
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
12.0026455
seq distance
12
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
12.0026455
seq distance
12
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
12.0026455
seq distance
12
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
12.0026455
seq distance
12
chain
D
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
12.845045
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
12.845045
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
14.091175
seq distance
14
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
14.091175
seq distance
14
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
14.091175
seq distance
14
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
14.091175
seq distance
14
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
14.091175
seq distance
14
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
14.091175
seq distance
14
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
15.947743
seq distance
22
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
15.947743
seq distance
22
chain
D
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
16.72006
seq distance
23
chain
D
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
16.72006
seq distance
23
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
17.805548
seq distance
27
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
17.805548
seq distance
27
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
18.73326
seq distance
32
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
18.73326
seq distance
32
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
20.462486
seq distance
38
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
20.462486
seq distance
38
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
20.531784
seq distance
39
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
20.531784
seq distance
39
chain
D
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
20.633
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
20.633
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
21.183931
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
21.183931
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
21.814283
seq distance
41
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
21.814283
seq distance
41
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
21.85402
seq distance
29
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
21.85402
seq distance
29
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
21.85402
seq distance
29
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
21.85402
seq distance
29
chain
D
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
22.37635
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
22.37635
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
22.40716
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
22.40716
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
22.575703
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
22.575703
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
22.683811
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
22.683811
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
22.71074
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
22.71074
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
22.739012
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
22.739012
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
22.74482
seq distance
30
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
22.74482
seq distance
30
chain
D
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
23.87257
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
23.87257
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
24.18994
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
24.18994
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
24.815355
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
24.815355
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
25.133759
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
25.133759
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
26.485415
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
26.485415
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
26.562145
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
26.562145
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
26.562145
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
26.562145
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
28.337526
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
28.337526
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
28.508411
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
28.508411
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
29.166927
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
29.166927
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
29.273062
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
29.273062
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
29.273062
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
29.273062
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
29.449074
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
29.449074
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
29.639658
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
29.639658
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
29.639658
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
29.639658
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
29.668638
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
29.668638
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
29.999578
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
29.999578
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
30.140299
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
30.140299
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
30.676912
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
30.676912
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
30.900944
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
30.900944
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
31.096853
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
31.096853
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
31.858496
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
31.858496
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
32.558517
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
32.558517
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
32.558517
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
32.558517
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
32.558517
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
32.558517
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
32.768875
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
32.768875
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
33.196762
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
33.196762
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
34.27048
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
34.27048
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
34.61644
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
34.61644
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
35.3524
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
35.3524
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
35.3524
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
35.3524
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
37.447495
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
37.447495
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
38.314713
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
38.314713
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
38.668716
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
38.668716
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
38.79767
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
38.79767
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
39.03185
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
39.03185
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
41.821
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
41.821
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
43.617474
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
43.617474
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
44.10083
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
44.10083
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
44.10083
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
44.10083
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
52.395107
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
52.395107
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
56.644947
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
56.644947
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
68.50609
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
68.50609
seq distance
False
chain
C
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
90.56188
seq distance
False
chain
B
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
90.56188
seq distance
False
chain
B

Details

Redox score
72.97
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
4.09
Half-sphere exposure sum
73
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
147 (Residue 105 in this structure)
Residue number B
151 (Residue 109 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
2.7661178
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
2.7661178
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
3.1860354
seq distance
7
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
3.1860354
seq distance
6
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
3.1860354
seq distance
7
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
3.1860354
seq distance
6
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
4.0853834
seq distance
4
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
4.0853834
seq distance
4
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
4.981074
seq distance
3
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
4.981074
seq distance
3
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.4883623
seq distance
1
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.4883623
seq distance
1
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
7.8605275
seq distance
9
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
7.8605275
seq distance
13
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
7.8605275
seq distance
13
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
7.8605275
seq distance
9
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
7.8605275
seq distance
13
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
7.8605275
seq distance
13
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.291048
seq distance
2
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.291048
seq distance
2
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.291048
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.291048
seq distance
2
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.291048
seq distance
2
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.291048
seq distance
2
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
13.125033
seq distance
9
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
13.125033
seq distance
9
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
14.190886
seq distance
5
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
14.190886
seq distance
5
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
16.339018
seq distance
13
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
16.339018
seq distance
14
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
16.339018
seq distance
13
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
16.339018
seq distance
14
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
17.663523
seq distance
16
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
17.663523
seq distance
16
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
20.1066
seq distance
False
chain
C
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
20.1066
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
22.428732
seq distance
44
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
22.428732
seq distance
44
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
22.693565
seq distance
18
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
22.693565
seq distance
18
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
24.611551
seq distance
30
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
24.611551
seq distance
30
chain
L
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
26.966316
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
26.966316
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
27.54644
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
27.54644
seq distance
False
chain
C
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
28.653355
seq distance
32
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
28.653355
seq distance
32
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
28.653355
seq distance
32
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
28.653355
seq distance
32
chain
L
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
29.79243
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
29.79243
seq distance
False
chain
C
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
30.548046
seq distance
47
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
30.548046
seq distance
47
chain
L
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
31.819038
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
31.819038
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
32.367958
seq distance
52
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
32.367958
seq distance
52
chain
L
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
33.85028
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
33.85028
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
34.99778
seq distance
50
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
34.99778
seq distance
50
chain
L
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
35.835575
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
35.835575
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
35.835575
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
35.835575
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.370464
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.370464
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
36.631447
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
36.631447
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
36.76392
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
36.76392
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
37.14609
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
37.14609
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
38.40428
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
38.40428
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.203587
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.203587
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
39.313705
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
39.313705
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.88439
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.88439
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
39.990612
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
39.990612
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
40.13014
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
40.13014
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
40.538517
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
40.538517
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
40.538517
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
40.538517
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
40.781437
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
40.781437
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
40.89936
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
40.89936
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
40.89936
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
40.89936
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
40.89936
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
40.89936
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
41.09881
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
41.09881
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
41.538
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
41.538
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.88634
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.88634
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
42.3709
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
42.3709
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
42.48857
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
42.48857
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
43.77861
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
43.77861
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
45.45353
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
45.45353
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.69478
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.69478
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
45.871944
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
45.871944
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
45.940865
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
45.940865
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
45.963486
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
45.963486
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
46.026165
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
46.026165
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
46.3709
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
46.3709
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
47.109566
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
47.109566
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
47.152256
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
47.152256
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
47.152256
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
47.152256
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
47.710545
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
47.710545
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
50.269444
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
50.269444
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
50.772186
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
50.772186
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
51.06964
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
51.06964
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
51.06964
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
51.06964
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
52.97922
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
52.97922
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
53.517303
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
53.517303
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
53.76312
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
53.76312
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
53.76312
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
53.76312
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
54.13776
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
54.13776
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.562424
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.562424
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
56.899
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
56.899
seq distance
False
chain
C

Details

Redox score
72.5
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
4.49
Half-sphere exposure sum
60
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
105 (Residue 63 in this structure)
Residue number B
131 (Residue 89 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
2.8276103
seq distance
0
chain
D
EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
2.8276103
seq distance
0
chain
D
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
2.8474553
seq distance
0
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
2.8474553
seq distance
0
chain
D
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
2.8474553
seq distance
0
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
2.8474553
seq distance
0
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
4.355136
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
4.355136
seq distance
2
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
4.355136
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
4.355136
seq distance
2
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
6.1721063
seq distance
2
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
6.1721063
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
7.189679
seq distance
5
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
7.189679
seq distance
5
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
8.19501
seq distance
3
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
8.19501
seq distance
3
chain
D
EGF-like 2
begin
94
end
134
score
100.0
distance
10.836805
seq distance
16
chain
D
EGF-like 2
begin
94
end
134
score
100.0
distance
10.836805
seq distance
16
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
11.870263
seq distance
13
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
11.870263
seq distance
13
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
11.870263
seq distance
13
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
11.870263
seq distance
13
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
11.870263
seq distance
13
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
11.870263
seq distance
13
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
18.90335
seq distance
41
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
18.90335
seq distance
41
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
19.635332
seq distance
55
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
19.635332
seq distance
55
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
20.378698
seq distance
27
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
20.378698
seq distance
27
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
21.896708
seq distance
24
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
21.896708
seq distance
25
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
21.896708
seq distance
24
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
21.896708
seq distance
25
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
22.075005
seq distance
58
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
22.075005
seq distance
58
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
23.456837
seq distance
29
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
23.456837
seq distance
29
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
24.549091
seq distance
43
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
24.549091
seq distance
43
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
24.549091
seq distance
43
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
24.549091
seq distance
43
chain
D
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
27.542809
seq distance
False
chain
A
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
27.542809
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
28.755323
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
28.755323
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
30.009409
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
30.009409
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
30.512424
seq distance
63
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
30.512424
seq distance
63
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
30.76526
seq distance
61
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
30.76526
seq distance
61
chain
D
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
34.97264
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
34.97264
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
35.024925
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
35.024925
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
35.861523
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
35.861523
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
36.942844
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
36.942844
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
37.640816
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
37.640816
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
37.640816
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
37.640816
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
38.088554
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
38.088554
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
38.20895
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
38.20895
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
40.074345
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
40.074345
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
40.4436
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
40.4436
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
40.94863
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
40.94863
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
41.15492
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
41.15492
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
42.72357
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
42.72357
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
42.9227
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
42.9227
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
44.346428
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
44.346428
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
44.6051
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
44.6051
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
44.863346
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
44.863346
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
44.863346
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
44.863346
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
44.863346
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
44.863346
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
45.04066
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
45.04066
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
45.23827
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
45.23827
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
45.476433
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
45.476433
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
45.476433
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
45.476433
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
45.58471
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
45.58471
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
45.76393
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
45.76393
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
46.59035
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
46.59035
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
46.59035
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
46.59035
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
47.092922
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
47.092922
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
47.323246
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
47.323246
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
47.389664
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
47.389664
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
48.000385
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
48.000385
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
48.305748
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
48.305748
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
49.546413
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
49.546413
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
50.164837
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
50.164837
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
50.433266
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
50.433266
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
50.744488
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
50.744488
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
51.041397
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
51.041397
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
52.73947
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
52.73947
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
52.73947
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
52.73947
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
54.418262
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
54.418262
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
54.656124
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
54.656124
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
55.507626
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
55.507626
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
56.06149
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
56.06149
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
56.845367
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
56.845367
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
57.073917
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
57.073917
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
57.073917
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
57.073917
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
58.103287
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
58.103287
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
58.143238
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
58.143238
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
71.89288
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
71.89288
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
76.69655
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
76.69655
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
89.925156
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
89.925156
seq distance
False
chain
C
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
110.58382
seq distance
False
chain
B
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
110.58382
seq distance
False
chain
B

Details

Redox score
72.49
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
5.34
Half-sphere exposure sum
48
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
111 (Residue 69 in this structure)
Residue number B
120 (Residue 78 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
2.8122087
seq distance
0
chain
I
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
2.8122087
seq distance
0
chain
I
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
2.8122087
seq distance
0
chain
I
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
2.8122087
seq distance
0
chain
I
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
4.116822
seq distance
2
chain
I
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
4.116822
seq distance
2
chain
I
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
4.116822
seq distance
2
chain
I
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
4.116822
seq distance
2
chain
I
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
6.398411
seq distance
14
chain
I
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
6.398411
seq distance
14
chain
I
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
6.668603
seq distance
2
chain
I
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
6.668603
seq distance
2
chain
I
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
8.364836
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
8.364836
seq distance
False
chain
G
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
8.364836
seq distance
False
chain
G
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
8.364836
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
9.622418
seq distance
28
chain
I
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
9.622418
seq distance
28
chain
I
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
10.256926
seq distance
False
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
10.256926
seq distance
False
chain
G
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
10.256926
seq distance
False
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
10.256926
seq distance
False
chain
G
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
11.855586
seq distance
16
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
11.855586
seq distance
16
chain
I
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
11.855586
seq distance
16
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
11.855586
seq distance
16
chain
I
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
12.49289
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
12.49289
seq distance
False
chain
G
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
12.837405
seq distance
False
chain
G
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
12.837405
seq distance
False
chain
G
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
17.964176
seq distance
31
chain
I
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
17.964176
seq distance
31
chain
I
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
18.541195
seq distance
36
chain
I
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
18.541195
seq distance
36
chain
I
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
21.115488
seq distance
False
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
21.115488
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
21.440475
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
21.440475
seq distance
False
chain
G
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
22.395205
seq distance
False
chain
G
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
22.395205
seq distance
False
chain
G
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
22.409119
seq distance
False
chain
G
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
22.409119
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
22.72709
seq distance
34
chain
I
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
22.72709
seq distance
34
chain
I
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
22.861355
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
22.861355
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
22.872587
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
22.872587
seq distance
False
chain
G
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
22.90349
seq distance
False
chain
G
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
22.90349
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
23.286264
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
23.286264
seq distance
False
chain
G
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
23.310942
seq distance
False
chain
G
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
23.310942
seq distance
False
chain
G
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
23.76005
seq distance
False
chain
G
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
23.76005
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
25.331545
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
25.331545
seq distance
False
chain
G
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
25.743551
seq distance
False
chain
G
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
25.743551
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
26.49049
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
26.49049
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
26.579712
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
26.579712
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
26.579712
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
26.579712
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
28.537249
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
28.537249
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
28.76132
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
28.76132
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
29.10018
seq distance
False
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
29.10018
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
29.10018
seq distance
False
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
29.10018
seq distance
False
chain
G
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
29.303093
seq distance
False
chain
G
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
29.303093
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
29.684715
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
29.684715
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
29.89395
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
29.89395
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
30.134508
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
30.134508
seq distance
False
chain
G
Charge relay system
position
299
score
100.0
distance
30.145445
seq distance
False
chain
G
Charge relay system
position
299
score
100.0
distance
30.145445
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
30.319963
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
30.319963
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
30.319963
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
30.319963
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
30.88958
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
30.88958
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
31.116093
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
31.116093
seq distance
False
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
31.195421
seq distance
False
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
31.195421
seq distance
False
chain
G
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
32.334118
seq distance
False
chain
G
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
32.334118
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
32.358692
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
32.358692
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
32.91795
seq distance
False
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
32.91795
seq distance
False
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
32.91795
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
32.91795
seq distance
False
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
32.91795
seq distance
False
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
32.91795
seq distance
False
chain
G
Charge relay system
position
402
score
100.0
distance
33.2834
seq distance
False
chain
G
Charge relay system
position
402
score
100.0
distance
33.2834
seq distance
False
chain
G
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
34.21778
seq distance
False
chain
G
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
34.21778
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
35.051586
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
35.051586
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
35.8938
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
35.8938
seq distance
False
chain
G
Charge relay system
position
253
score
100.0
distance
35.8938
seq distance
False
chain
G
Charge relay system
position
253
score
100.0
distance
35.8938
seq distance
False
chain
G
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
36.744366
seq distance
False
chain
G
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
36.744366
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
37.287685
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
37.287685
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
37.79986
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
37.79986
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
38.41275
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
38.41275
seq distance
False
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
38.940975
seq distance
False
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
38.940975
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
39.040047
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
39.040047
seq distance
False
chain
H
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
39.07192
seq distance
False
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
39.07192
seq distance
False
chain
G
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
41.82726
seq distance
False
chain
A
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
41.82726
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
41.93027
seq distance
False
chain
G
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
41.93027
seq distance
False
chain
G
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
43.037926
seq distance
False
chain
G
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
43.037926
seq distance
False
chain
G
Phosphoserine; by FAM20C
position
347
score
100.0
distance
43.61617
seq distance
False
chain
G
Phosphoserine; by FAM20C
position
347
score
100.0
distance
43.61617
seq distance
False
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
44.179585
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
44.179585
seq distance
False
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
44.179585
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
44.179585
seq distance
False
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
46.80651
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
46.80651
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
46.80651
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
46.80651
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
47.360992
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
47.360992
seq distance
False
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
47.672226
seq distance
False
chain
G
4-carboxyglutamate
position
349
score
50.0
distance
47.672226
seq distance
False
chain
G
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
48.66404
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
48.66404
seq distance
False
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
49.679874
seq distance
False
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
49.679874
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
50.474472
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
50.474472
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
50.634254
seq distance
False
chain
K
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
50.634254
seq distance
False
chain
K
Phosphoserine; by FAM20C
position
347
score
100.0
distance
52.064842
seq distance
False
chain
A
Phosphoserine; by FAM20C
position
347
score
100.0
distance
52.064842
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
53.47831
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
53.47831
seq distance
False
chain
A
Charge relay system
position
7
score
50.0
distance
54.083366
seq distance
False
chain
H
Charge relay system
position
7
score
50.0
distance
54.083366
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
56.700893
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
56.700893
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
56.700893
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
56.700893
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
56.700893
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
56.700893
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
56.883694
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
56.883694
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
57.587025
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
57.587025
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
57.79382
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
57.79382
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
57.905987
seq distance
False
chain
J
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
57.905987
seq distance
False
chain
J
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
58.31
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
58.31
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
59.420685
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
59.420685
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
59.55245
seq distance
False
chain
K
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
59.55245
seq distance
False
chain
K
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
59.80203
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
59.80203
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
61.30103
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
61.30103
seq distance
False
chain
A
Charge relay system
position
402
score
100.0
distance
61.42241
seq distance
False
chain
A
Charge relay system
position
402
score
100.0
distance
61.42241
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
62.057518
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
62.057518
seq distance
False
chain
A
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
62.258972
seq distance
False
chain
A
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
62.258972
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
62.512703
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
62.512703
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
63.328304
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
63.328304
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
63.659824
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
63.659824
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
64.40807
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
64.40807
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
64.52844
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
64.52844
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
64.81363
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
64.81363
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
66.1243
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
66.1243
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
66.1243
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
66.1243
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
66.36841
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
66.36841
seq distance
False
chain
A
Charge relay system
position
253
score
100.0
distance
66.36841
seq distance
False
chain
A
Charge relay system
position
253
score
100.0
distance
66.36841
seq distance
False
chain
A
Charge relay system
position
7
score
50.0
distance
66.61809
seq distance
False
chain
K
Charge relay system
position
7
score
50.0
distance
66.61809
seq distance
False
chain
K
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
67.864006
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
67.864006
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
67.864006
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
67.864006
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
68.48786
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
68.48786
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
69.62571
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
69.62571
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
70.174385
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
70.174385
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
70.73678
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
70.73678
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
70.73678
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
70.73678
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
70.76745
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
70.76745
seq distance
False
chain
A
Charge relay system
position
299
score
100.0
distance
70.82115
seq distance
False
chain
A
Charge relay system
position
299
score
100.0
distance
70.82115
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
70.87564
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
70.87564
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
71.424774
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
71.424774
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
71.53711
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
71.53711
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
71.99796
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
71.99796
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
72.77811
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
72.77811
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
72.86895
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
72.86895
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
73.44588
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
73.44588
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
73.555695
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
73.555695
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
73.70137
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
73.70137
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
74.52292
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
74.52292
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
74.982056
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
74.982056
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
77.67804
seq distance
False
chain
L
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
77.67804
seq distance
False
chain
L
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
78.317566
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
78.317566
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
78.37403
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
78.37403
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
78.39658
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
78.39658
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
78.68825
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
78.68825
seq distance
False
chain
A
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
79.49707
seq distance
False
chain
B
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
79.49707
seq distance
False
chain
B
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
79.762085
seq distance
False
chain
K
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
79.762085
seq distance
False
chain
K
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
80.35762
seq distance
False
chain
B
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
80.35762
seq distance
False
chain
B
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
80.40863
seq distance
False
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
80.40863
seq distance
False
chain
B
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
80.40863
seq distance
False
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
80.40863
seq distance
False
chain
B
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
80.88482
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
80.88482
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
81.26384
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
81.26384
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
81.3195
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
81.3195
seq distance
False
chain
B
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
81.47487
seq distance
False
chain
C
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
81.47487
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
82.11322
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
82.11322
seq distance
False
chain
B
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
82.46535
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
82.46535
seq distance
False
chain
A
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
82.46535
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
82.46535
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
82.61946
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
82.61946
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
83.31079
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
83.31079
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
84.60936
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
84.60936
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
84.6707
seq distance
False
chain
B
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
84.6707
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
85.17445
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
85.17445
seq distance
False
chain
B
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
85.237785
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
85.237785
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
85.237785
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
85.237785
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
86.16249
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
86.16249
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
86.67819
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
86.67819
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
87.882545
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
87.882545
seq distance
False
chain
C
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
88.00408
seq distance
False
chain
B
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
88.00408
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
88.18479
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
88.18479
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
88.18479
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
88.18479
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
92.399055
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
92.399055
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
92.399055
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
92.399055
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
92.399055
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
92.399055
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
93.76127
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
93.76127
seq distance
False
chain
D
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
94.26214
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
94.26214
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
94.42554
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
94.42554
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
94.57956
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
94.57956
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
95.294945
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
95.294945
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
95.44827
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
95.44827
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
96.77544
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
96.77544
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
96.94247
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
96.94247
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
97.4367
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
97.4367
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
98.18658
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
98.18658
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
98.18658
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
98.18658
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
98.415
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
98.415
seq distance
False
chain
D
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
98.61197
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
98.61197
seq distance
False
chain
C
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
99.00018
seq distance
False
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
99.00018
seq distance
False
chain
D
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
99.3049
seq distance
False
chain
D
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
99.3049
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
99.4384
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
99.4384
seq distance
False
chain
C
Charge relay system
position
253
score
100.0
distance
99.4384
seq distance
False
chain
C
Charge relay system
position
253
score
100.0
distance
99.4384
seq distance
False
chain
C
Charge relay system
position
402
score
100.0
distance
99.51158
seq distance
False
chain
C
Charge relay system
position
402
score
100.0
distance
99.51158
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
99.87211
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
99.87211
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
101.345314
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
101.345314
seq distance
False
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
101.73042
seq distance
False
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
101.73042
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
102.92687
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
102.92687
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
103.38297
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
103.38297
seq distance
False
chain
C
Charge relay system
position
299
score
100.0
distance
103.94131
seq distance
False
chain
C
Charge relay system
position
299
score
100.0
distance
103.94131
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
104.08314
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
104.08314
seq distance
False
chain
C
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
104.189285
seq distance
False
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
104.189285
seq distance
False
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
104.189285
seq distance
False
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
104.189285
seq distance
False
chain
D
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
104.96013
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
104.96013
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
347
score
100.0
distance
105.79876
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
347
score
100.0
distance
105.79876
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
106.030174
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
106.030174
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
106.563416
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
106.563416
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
106.602844
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
106.602844
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
106.91026
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
106.91026
seq distance
False
chain
C
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
107.216736
seq distance
False
chain
C
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
107.216736
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
107.55511
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
107.55511
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
107.57988
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
107.57988
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
107.69134
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
107.69134
seq distance
False
chain
D
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
108.432274
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
108.432274
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
108.497116
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
108.497116
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
109.99312
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
109.99312
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
110.10339
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
110.10339
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
110.27622
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
110.27622
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
110.9135
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
110.9135
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
111.546745
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
111.546745
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
112.67298
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
112.67298
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
112.67298
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
112.67298
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
114.33497
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
114.33497
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
114.70739
seq distance
False
chain
F
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
114.70739
seq distance
False
chain
F
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
115.02103
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
115.02103
seq distance
False
chain
D
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
115.39294
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
115.39294
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
116.06915
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
116.06915
seq distance
False
chain
C
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
117.90419
seq distance
False
chain
C
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
117.90419
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
117.96267
seq distance
False
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
117.96267
seq distance
False
chain
D
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
118.07999
seq distance
False
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
118.07999
seq distance
False
chain
C
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
118.07999
seq distance
False
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
118.07999
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
118.125786
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
118.125786
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
119.76689
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
119.76689
seq distance
False
chain
C
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
120.07262
seq distance
False
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
120.07262
seq distance
False
chain
D
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
120.07314
seq distance
False
chain
F
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
120.07314
seq distance
False
chain
F
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
127.78728
seq distance
False
chain
F
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
127.78728
seq distance
False
chain
F
Charge relay system
position
7
score
50.0
distance
129.16089
seq distance
False
chain
F
Charge relay system
position
7
score
50.0
distance
129.16089
seq distance
False
chain
F
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
134.8284
seq distance
False
chain
E
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
134.8284
seq distance
False
chain
E

Details

Redox score
71.14
PDB code
6m3c
Structure name
hapc-h1573 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
5.69
Half-sphere exposure sum
63
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
140
Residue number B
147
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines.

Relevent regions

EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
2.8007395
seq distance
0
chain
D
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
2.8007395
seq distance
0
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
4.0782666
seq distance
4
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
4.0782666
seq distance
4
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
4.507313
seq distance
6
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
4.507313
seq distance
6
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
4.507313
seq distance
6
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
4.507313
seq distance
6
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
6.173524
seq distance
1
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
6.173524
seq distance
1
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
7.6688395
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
7.6688395
seq distance
2
chain
D
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
8.018782
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
8.018782
seq distance
False
chain
C
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
8.018782
seq distance
False
chain
C
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
8.018782
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
9.363421
seq distance
15
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
9.363421
seq distance
15
chain
D
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
10.549171
seq distance
False
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
10.549171
seq distance
False
chain
C
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
10.549171
seq distance
False
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
10.549171
seq distance
False
chain
C
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
12.233223
seq distance
3
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
12.233223
seq distance
3
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
12.233223
seq distance
3
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
12.233223
seq distance
3
chain
D
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
12.497405
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
12.497405
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
12.645856
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
12.645856
seq distance
False
chain
C
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
17.544802
seq distance
18
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
17.544802
seq distance
18
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
19.030922
seq distance
23
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
19.030922
seq distance
23
chain
D
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
20.652111
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
20.652111
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
20.943289
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
20.943289
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
21.985506
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
21.985506
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
22.279905
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
22.279905
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
22.466146
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
22.466146
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
22.475483
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
22.475483
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
23.015413
seq distance
21
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
23.015413
seq distance
21
chain
D
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
23.033878
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
23.033878
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
23.090935
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
23.090935
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
23.804432
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
23.804432
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
23.954357
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
23.954357
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
24.909801
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
24.909801
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
25.023462
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
25.023462
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
26.0661
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
26.0661
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
26.0661
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
26.0661
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
27.17394
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
27.17394
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
28.140661
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
28.140661
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
28.884802
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
28.884802
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
29.26411
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
29.26411
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
29.409891
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
29.409891
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
29.409891
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
29.409891
seq distance
False
chain
C
Charge relay system
position
299
score
100.0
distance
29.516212
seq distance
False
chain
C
Charge relay system
position
299
score
100.0
distance
29.516212
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
29.659359
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
29.659359
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
29.813803
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
29.813803
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
29.813803
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
29.813803
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
29.98093
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
29.98093
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
30.197811
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
30.197811
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
30.6434
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
30.6434
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
30.652386
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
30.652386
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
31.09141
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
31.09141
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
31.461308
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
31.461308
seq distance
False
chain
C
Charge relay system
position
402
score
100.0
distance
32.896328
seq distance
False
chain
C
Charge relay system
position
402
score
100.0
distance
32.896328
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
33.049583
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
33.049583
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
33.38098
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
33.38098
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
33.38098
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
33.38098
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
33.38098
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
33.38098
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
33.987164
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
33.987164
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
34.50199
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
34.50199
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
35.072014
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
35.072014
seq distance
False
chain
C
Charge relay system
position
253
score
100.0
distance
35.072014
seq distance
False
chain
C
Charge relay system
position
253
score
100.0
distance
35.072014
seq distance
False
chain
C
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
36.35269
seq distance
False
chain
C
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
36.35269
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
36.570377
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
36.570377
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
37.643
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
37.643
seq distance
False
chain
C
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
38.095932
seq distance
False
chain
C
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
38.095932
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
38.603626
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
38.603626
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
39.07125
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
39.07125
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
41.41376
seq distance
False
chain
L
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
41.41376
seq distance
False
chain
L
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
42.103683
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
42.103683
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
347
score
100.0
distance
42.736256
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
347
score
100.0
distance
42.736256
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
43.87313
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
43.87313
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
44.893566
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
44.893566
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
44.893566
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
44.893566
seq distance
False
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
46.876537
seq distance
False
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
46.876537
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
49.764545
seq distance
False
chain
F
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
49.764545
seq distance
False
chain
F
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
58.105717
seq distance
False
chain
E
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
58.105717
seq distance
False
chain
E
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
58.784412
seq distance
False
chain
F
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
58.784412
seq distance
False
chain
F
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
62.09851
seq distance
False
chain
A
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
62.09851
seq distance
False
chain
A
Charge relay system
position
7
score
50.0
distance
65.49932
seq distance
False
chain
F
Charge relay system
position
7
score
50.0
distance
65.49932
seq distance
False
chain
F
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
65.76194
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
65.76194
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
68.982895
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
68.982895
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
70.93834
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
70.93834
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
72.08245
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
72.08245
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
72.1573
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
72.1573
seq distance
False
chain
A
Charge relay system
position
7
score
50.0
distance
73.11686
seq distance
False
chain
H
Charge relay system
position
7
score
50.0
distance
73.11686
seq distance
False
chain
H
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
73.202255
seq distance
False
chain
A
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
73.202255
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
73.319595
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
73.319595
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
74.07675
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
74.07675
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
74.89053
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
74.89053
seq distance
False
chain
H
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
74.93799
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
74.93799
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
75.57282
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
75.57282
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
75.763435
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
75.763435
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
75.763435
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
75.763435
seq distance
False
chain
A
Phosphoserine; by FAM20C
position
347
score
100.0
distance
76.315765
seq distance
False
chain
A
Phosphoserine; by FAM20C
position
347
score
100.0
distance
76.315765
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
76.8808
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
76.8808
seq distance
False
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
76.92168
seq distance
False
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
76.92168
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
77.10274
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
77.10274
seq distance
False
chain
A
Charge relay system
position
299
score
100.0
distance
77.23679
seq distance
False
chain
A
Charge relay system
position
299
score
100.0
distance
77.23679
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
77.53445
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
77.53445
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
77.6066
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
77.6066
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
78.761665
seq distance
False
chain
F
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
78.761665
seq distance
False
chain
F
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
78.76701
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
78.76701
seq distance
False
chain
A
Charge relay system
position
253
score
100.0
distance
78.76701
seq distance
False
chain
A
Charge relay system
position
253
score
100.0
distance
78.76701
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
79.42639
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
79.42639
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
79.68086
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
79.68086
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
79.86762
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
79.86762
seq distance
False
chain
A
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
80.87906
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
80.87906
seq distance
False
chain
A
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
80.87906
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
80.87906
seq distance
False
chain
A
Charge relay system
position
402
score
100.0
distance
81.37866
seq distance
False
chain
A
Charge relay system
position
402
score
100.0
distance
81.37866
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
81.47314
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
81.47314
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
81.766014
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
81.766014
seq distance
False
chain
A
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
82.788734
seq distance
False
chain
B
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
82.788734
seq distance
False
chain
B
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
82.87386
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
82.87386
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
83.162445
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
83.162445
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
83.75574
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
83.75574
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
83.75574
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
83.75574
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
83.96172
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
83.96172
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
84.35993
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
84.35993
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
84.778694
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
84.778694
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
84.82962
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
84.82962
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
87.27828
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
87.27828
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
87.41262
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
87.41262
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
87.534325
seq distance
False
chain
B
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
87.534325
seq distance
False
chain
B
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
87.99582
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
87.99582
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
88.123955
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
88.123955
seq distance
False
chain
A
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
89.34608
seq distance
False
chain
B
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
89.34608
seq distance
False
chain
B
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
89.75392
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
89.75392
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
92.34505
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
92.34505
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
92.36019
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
92.36019
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
92.745255
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
92.745255
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
93.095116
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
93.095116
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
94.46206
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
94.46206
seq distance
False
chain
A
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
95.37876
seq distance
False
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
95.37876
seq distance
False
chain
B
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
95.37876
seq distance
False
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
95.37876
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
95.5226
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
95.5226
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
95.84241
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
95.84241
seq distance
False
chain
B
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
95.910126
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
95.910126
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
97.22414
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
97.22414
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
97.45074
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
97.45074
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
97.67907
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
97.67907
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
98.02006
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
98.02006
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
98.02006
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
98.02006
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
98.977905
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
98.977905
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
98.977905
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
98.977905
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
98.977905
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
98.977905
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
99.48514
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
99.48514
seq distance
False
chain
B
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
101.043465
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
101.043465
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
101.61043
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
101.61043
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
103.506516
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
103.506516
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
104.75765
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
104.75765
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
104.75765
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
104.75765
seq distance
False
chain
A
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
105.67264
seq distance
False
chain
B
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
105.67264
seq distance
False
chain
B
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
108.1535
seq distance
False
chain
J
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
108.1535
seq distance
False
chain
J
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
109.86462
seq distance
False
chain
G
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
109.86462
seq distance
False
chain
G
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
110.08796
seq distance
False
chain
I
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
110.08796
seq distance
False
chain
I
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
111.52401
seq distance
False
chain
G
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
111.52401
seq distance
False
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
112.62822
seq distance
False
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
112.62822
seq distance
False
chain
G
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
114.2986
seq distance
False
chain
G
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
114.2986
seq distance
False
chain
G
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
114.57827
seq distance
False
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
114.57827
seq distance
False
chain
G
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
114.57827
seq distance
False
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
114.57827
seq distance
False
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
114.96787
seq distance
False
chain
K
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
114.96787
seq distance
False
chain
K
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
114.9819
seq distance
False
chain
I
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
114.9819
seq distance
False
chain
I
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
114.9819
seq distance
False
chain
I
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
114.9819
seq distance
False
chain
I
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
116.44603
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
116.44603
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
116.64443
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
116.64443
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
118.37811
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
118.37811
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
118.37811
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
118.37811
seq distance
False
chain
G
Charge relay system
position
7
score
50.0
distance
118.53138
seq distance
False
chain
K
Charge relay system
position
7
score
50.0
distance
118.53138
seq distance
False
chain
K
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
118.81894
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
118.81894
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
120.04351
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
120.04351
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
121.28047
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
121.28047
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
121.43376
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
121.43376
seq distance
False
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
121.78044
seq distance
False
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
121.78044
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
122.917206
seq distance
False
chain
K
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
122.917206
seq distance
False
chain
K
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
123.72504
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
123.72504
seq distance
False
chain
I
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
124.56015
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
124.56015
seq distance
False
chain
G
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
125.468765
seq distance
False
chain
G
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
125.468765
seq distance
False
chain
G
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
125.48572
seq distance
False
chain
G
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
125.48572
seq distance
False
chain
G
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
125.719795
seq distance
False
chain
G
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
125.719795
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
125.84328
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
125.84328
seq distance
False
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
125.88876
seq distance
False
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
125.88876
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
125.93442
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
125.93442
seq distance
False
chain
I
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
126.62913
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
126.62913
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
127.6842
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
127.6842
seq distance
False
chain
I
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
127.880295
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
127.880295
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
128.03528
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
128.03528
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
128.36691
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
128.36691
seq distance
False
chain
G
Phosphoserine; by FAM20C
position
347
score
100.0
distance
128.63618
seq distance
False
chain
G
Phosphoserine; by FAM20C
position
347
score
100.0
distance
128.63618
seq distance
False
chain
G
Charge relay system
position
299
score
100.0
distance
129.88554
seq distance
False
chain
G
Charge relay system
position
299
score
100.0
distance
129.88554
seq distance
False
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
130.01974
seq distance
False
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
130.01974
seq distance
False
chain
G
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
130.05568
seq distance
False
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
130.05568
seq distance
False
chain
I
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
130.05568
seq distance
False
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
130.05568
seq distance
False
chain
I
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
130.83383
seq distance
False
chain
G
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
130.83383
seq distance
False
chain
G
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
131.74193
seq distance
False
chain
G
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
131.74193
seq distance
False
chain
G
Charge relay system
position
402
score
100.0
distance
132.5196
seq distance
False
chain
G
Charge relay system
position
402
score
100.0
distance
132.5196
seq distance
False
chain
G
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
133.02248
seq distance
False
chain
G
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
133.02248
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
133.47675
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
133.47675
seq distance
False
chain
G
4-carboxyglutamate
position
349
score
50.0
distance
133.67583
seq distance
False
chain
G
4-carboxyglutamate
position
349
score
50.0
distance
133.67583
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
133.843
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
133.843
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
134.00822
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
134.00822
seq distance
False
chain
I
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
134.44308
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
134.44308
seq distance
False
chain
G
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
134.52629
seq distance
False
chain
G
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
134.52629
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
134.79259
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
134.79259
seq distance
False
chain
G
Charge relay system
position
253
score
100.0
distance
134.79259
seq distance
False
chain
G
Charge relay system
position
253
score
100.0
distance
134.79259
seq distance
False
chain
G
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
135.32672
seq distance
False
chain
G
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
135.32672
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
135.53096
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
135.53096
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
135.53096
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
135.53096
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
136.15086
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
136.15086
seq distance
False
chain
G
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
136.3125
seq distance
False
chain
G
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
136.3125
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
136.46918
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
136.46918
seq distance
False
chain
G
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
136.81505
seq distance
False
chain
I
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
136.81505
seq distance
False
chain
I
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
137.7509
seq distance
False
chain
K
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
137.7509
seq distance
False
chain
K
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
137.99698
seq distance
False
chain
G
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
137.99698
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
138.30203
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
138.30203
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
138.58049
seq distance
False
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
138.58049
seq distance
False
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
138.58049
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
138.58049
seq distance
False
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
138.58049
seq distance
False
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
138.58049
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
139.26096
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
139.26096
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
142.97382
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
142.97382
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
143.65948
seq distance
False
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
143.65948
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
143.65948
seq distance
False
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
143.65948
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
146.2493
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
146.2493
seq distance
False
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
146.46054
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
146.46054
seq distance
False
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
146.46054
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
146.46054
seq distance
False
chain
G
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
147.7976
seq distance
False
chain
G
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
147.7976
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
149.83105
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
149.83105
seq distance
False
chain
G

Details

Redox score
71
PDB code
6m3c
Structure name
hapc-h1573 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
5.23
Half-sphere exposure sum
69
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
151
Residue number B
160
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
2.8018796
seq distance
0
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
2.8018796
seq distance
0
chain
D
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
2.8018796
seq distance
0
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
2.8018796
seq distance
0
chain
D
EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
2.8018796
seq distance
0
chain
D
EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
2.8018796
seq distance
0
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
5.6793404
seq distance
11
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
5.6793404
seq distance
11
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
6.666515
seq distance
12
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
6.666515
seq distance
12
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
7.147066
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
7.147066
seq distance
2
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
7.147066
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
7.147066
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
7.189679
seq distance
14
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
7.189679
seq distance
14
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.072797
seq distance
11
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.072797
seq distance
11
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.072797
seq distance
11
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.072797
seq distance
11
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.072797
seq distance
11
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.072797
seq distance
11
chain
D
EGF-like 2
begin
94
end
134
score
100.0
distance
9.940596
seq distance
14
chain
D
EGF-like 2
begin
94
end
134
score
100.0
distance
9.940596
seq distance
14
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
15.975851
seq distance
39
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
15.975851
seq distance
39
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
16.15935
seq distance
25
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
16.15935
seq distance
25
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
16.519634
seq distance
22
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
16.519634
seq distance
23
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
16.519634
seq distance
22
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
16.519634
seq distance
23
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
17.852486
seq distance
53
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
17.852486
seq distance
53
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
20.156239
seq distance
27
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
20.156239
seq distance
27
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
22.075005
seq distance
56
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
22.075005
seq distance
56
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
22.575157
seq distance
41
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
22.575157
seq distance
41
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
22.575157
seq distance
41
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
22.575157
seq distance
41
chain
D
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
24.201185
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
24.201185
seq distance
False
chain
A
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
24.201185
seq distance
False
chain
A
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
24.201185
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
26.728708
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
26.728708
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
29.296368
seq distance
61
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
29.296368
seq distance
61
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
30.76526
seq distance
59
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
30.76526
seq distance
59
chain
D
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
33.70452
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
33.70452
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
34.03923
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
34.03923
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
34.24209
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
34.24209
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
34.59572
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
34.59572
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
34.939907
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
34.939907
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
35.394375
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
35.394375
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
36.424267
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
36.424267
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
37.513817
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
37.513817
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
37.640816
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
37.640816
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
37.640816
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
37.640816
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
38.503876
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
38.503876
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
38.724804
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
38.724804
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
40.070866
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
40.070866
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
40.56272
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
40.56272
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
40.727795
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
40.727795
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
40.994133
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
40.994133
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
41.084267
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
41.084267
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
42.387703
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
42.387703
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
42.387703
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
42.387703
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
42.94262
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
42.94262
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
43.04628
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
43.04628
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
43.04628
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
43.04628
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
43.17364
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
43.17364
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
43.582012
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
43.582012
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
43.742474
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
43.742474
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
43.742474
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
43.742474
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
43.742474
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
43.742474
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
43.79026
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
43.79026
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
44.11117
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
44.11117
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
44.2329
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
44.2329
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
44.735912
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
44.735912
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
45.457394
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
45.457394
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
46.394505
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
46.394505
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
46.77985
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
46.77985
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
47.61204
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
47.61204
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
48.33228
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
48.33228
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
48.970356
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
48.970356
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
49.904373
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
49.904373
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
49.904373
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
49.904373
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
50.574593
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
50.574593
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
52.14715
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
52.14715
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
52.29367
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
52.29367
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.480923
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.480923
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
54.484894
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
54.484894
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
54.81248
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
54.81248
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
54.837273
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
54.837273
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
55.994415
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
55.994415
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
55.994415
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
55.994415
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
67.95411
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
67.95411
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
72.239685
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
72.239685
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
84.90449
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
84.90449
seq distance
False
chain
C
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
106.73107
seq distance
False
chain
B
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
106.73107
seq distance
False
chain
B

Details

Redox score
70.75
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
6.35
Half-sphere exposure sum
51
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
120 (Residue 78 in this structure)
Residue number B
122 (Residue 80 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
2.8474553
seq distance
0
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
2.8474553
seq distance
0
chain
D
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
2.8474553
seq distance
0
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
2.8474553
seq distance
0
chain
D
EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
2.8474553
seq distance
0
chain
D
EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
2.8474553
seq distance
0
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
5.3681436
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
5.3681436
seq distance
2
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
5.3681436
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
5.3681436
seq distance
2
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
6.1721063
seq distance
11
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
6.1721063
seq distance
11
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
7.189679
seq distance
14
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
7.189679
seq distance
14
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
8.19501
seq distance
12
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
8.19501
seq distance
12
chain
D
EGF-like 2
begin
94
end
134
score
100.0
distance
10.836805
seq distance
16
chain
D
EGF-like 2
begin
94
end
134
score
100.0
distance
10.836805
seq distance
16
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
11.870263
seq distance
13
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
11.870263
seq distance
13
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
11.870263
seq distance
13
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
11.870263
seq distance
13
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
11.870263
seq distance
13
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
11.870263
seq distance
13
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
18.90335
seq distance
41
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
18.90335
seq distance
41
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
19.635332
seq distance
55
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
19.635332
seq distance
55
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
20.378698
seq distance
27
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
20.378698
seq distance
27
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
21.896708
seq distance
24
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
21.896708
seq distance
25
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
21.896708
seq distance
24
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
21.896708
seq distance
25
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
22.075005
seq distance
58
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
22.075005
seq distance
58
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
23.456837
seq distance
29
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
23.456837
seq distance
29
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
24.549091
seq distance
43
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
24.549091
seq distance
43
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
24.549091
seq distance
43
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
24.549091
seq distance
43
chain
D
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
27.542809
seq distance
False
chain
A
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
27.542809
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
28.755323
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
28.755323
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
30.009409
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
30.009409
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
30.512424
seq distance
63
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
30.512424
seq distance
63
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
30.76526
seq distance
61
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
30.76526
seq distance
61
chain
D
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
34.97264
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
34.97264
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
35.024925
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
35.024925
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
35.861523
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
35.861523
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
36.942844
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
36.942844
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
37.640816
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
37.640816
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
37.640816
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
37.640816
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
38.088554
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
38.088554
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
38.20895
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
38.20895
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
40.074345
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
40.074345
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
40.4436
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
40.4436
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
40.94863
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
40.94863
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
41.15492
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
41.15492
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
42.72357
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
42.72357
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
42.9227
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
42.9227
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
44.346428
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
44.346428
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
44.6051
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
44.6051
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
44.863346
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
44.863346
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
44.863346
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
44.863346
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
44.863346
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
44.863346
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
45.04066
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
45.04066
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
45.23827
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
45.23827
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
45.476433
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
45.476433
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
45.476433
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
45.476433
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
45.58471
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
45.58471
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
45.76393
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
45.76393
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
46.59035
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
46.59035
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
46.59035
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
46.59035
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
47.092922
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
47.092922
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
47.323246
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
47.323246
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
47.389664
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
47.389664
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
48.000385
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
48.000385
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
48.305748
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
48.305748
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
49.546413
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
49.546413
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
50.164837
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
50.164837
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
50.433266
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
50.433266
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
50.744488
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
50.744488
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
51.041397
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
51.041397
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
52.73947
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
52.73947
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
52.73947
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
52.73947
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
54.418262
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
54.418262
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
54.656124
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
54.656124
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
55.507626
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
55.507626
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
56.06149
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
56.06149
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
56.845367
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
56.845367
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
57.073917
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
57.073917
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
57.073917
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
57.073917
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
58.103287
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
58.103287
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
58.143238
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
58.143238
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
71.89288
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
71.89288
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
76.69655
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
76.69655
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
89.925156
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
89.925156
seq distance
False
chain
C
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
110.58382
seq distance
False
chain
B
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
110.58382
seq distance
False
chain
B

Details

Redox score
70.12
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
7.15
Half-sphere exposure sum
nan
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
92 (Residue 50 in this structure)
Residue number B
120 (Residue 78 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
2.8235548
seq distance
0
chain
D
EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
2.8235548
seq distance
0
chain
D
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
3.6838088
seq distance
15
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
3.6838088
seq distance
15
chain
D
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
3.6838088
seq distance
15
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
3.6838088
seq distance
15
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
4.8430524
seq distance
4
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
4.8430524
seq distance
4
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
5.3681436
seq distance
13
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
5.3681436
seq distance
13
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
5.3681436
seq distance
13
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
5.3681436
seq distance
13
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.543579
seq distance
1
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.543579
seq distance
1
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
7.116688
seq distance
3
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
7.116688
seq distance
3
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
12.47346
seq distance
28
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
12.47346
seq distance
28
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
12.47346
seq distance
28
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
12.47346
seq distance
28
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
12.47346
seq distance
28
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
12.47346
seq distance
28
chain
D
EGF-like 2
begin
94
end
134
score
100.0
distance
12.688789
seq distance
31
chain
D
EGF-like 2
begin
94
end
134
score
100.0
distance
12.688789
seq distance
31
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
20.638113
seq distance
56
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
20.638113
seq distance
56
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
21.56031
seq distance
70
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
21.56031
seq distance
70
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
21.9076
seq distance
42
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
21.9076
seq distance
42
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
23.065544
seq distance
39
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
23.065544
seq distance
40
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
23.065544
seq distance
39
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
23.065544
seq distance
40
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
24.123444
seq distance
73
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
24.123444
seq distance
73
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
25.212152
seq distance
44
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
25.212152
seq distance
44
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
26.459652
seq distance
58
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
26.459652
seq distance
58
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
26.459652
seq distance
58
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
26.459652
seq distance
58
chain
D
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
29.259628
seq distance
False
chain
A
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
29.259628
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
30.17032
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
30.17032
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
31.757635
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
31.757635
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
32.525337
seq distance
78
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
32.525337
seq distance
78
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
32.81577
seq distance
76
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
32.81577
seq distance
76
chain
D
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
36.979782
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
36.979782
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
36.992676
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
36.992676
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
37.811768
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
37.811768
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
38.663105
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
38.663105
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
39.688953
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
39.688953
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
39.688953
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
39.688953
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
39.694775
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
39.694775
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
39.832848
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
39.832848
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
41.997192
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
41.997192
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
42.424088
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
42.424088
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
42.595974
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
42.595974
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
42.705383
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
42.705383
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
44.479347
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
44.479347
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
44.714455
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
44.714455
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
46.038185
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
46.038185
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
46.640915
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
46.640915
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
46.809826
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
46.809826
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
46.849743
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
46.849743
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
46.849743
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
46.849743
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
46.849743
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
46.849743
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
46.955097
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
46.955097
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
46.978683
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
46.978683
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
47.27405
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
47.27405
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
47.27405
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
47.27405
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
47.66909
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
47.66909
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
48.209023
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
48.209023
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
48.209023
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
48.209023
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
48.712746
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
48.712746
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
49.130405
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
49.130405
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
49.19436
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
49.19436
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
49.708797
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
49.708797
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
49.89305
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
49.89305
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
51.362972
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
51.362972
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
51.753677
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
51.753677
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
52.29745
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
52.29745
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
52.42171
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
52.42171
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
52.935627
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
52.935627
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
54.532455
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
54.532455
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
54.532455
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
54.532455
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
56.114895
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
56.114895
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
56.580956
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
56.580956
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
57.545536
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
57.545536
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
57.765945
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
57.765945
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
58.795048
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
58.795048
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
59.10391
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
59.10391
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
59.10391
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
59.10391
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
59.750546
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
59.750546
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
59.860523
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
59.860523
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
73.32809
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
73.32809
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
77.95273
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
77.95273
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
91.18569
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
91.18569
seq distance
False
chain
C
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
112.18657
seq distance
False
chain
B
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
112.18657
seq distance
False
chain
B

Details

Redox score
69.84
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
6.78
Half-sphere exposure sum
nan
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
92 (Residue 50 in this structure)
Residue number B
105 (Residue 63 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
2.8018796
seq distance
0
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
2.8018796
seq distance
0
chain
D
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
2.8018796
seq distance
0
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
2.8018796
seq distance
0
chain
D
EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
2.8018796
seq distance
0
chain
D
EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
2.8018796
seq distance
0
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
4.8430524
seq distance
4
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
4.8430524
seq distance
4
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.543579
seq distance
1
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.543579
seq distance
1
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
6.666515
seq distance
3
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
6.666515
seq distance
3
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.072797
seq distance
11
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.072797
seq distance
11
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.072797
seq distance
11
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.072797
seq distance
11
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.072797
seq distance
11
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.072797
seq distance
11
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
8.220964
seq distance
4
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
8.220964
seq distance
4
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
8.220964
seq distance
4
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
8.220964
seq distance
4
chain
D
EGF-like 2
begin
94
end
134
score
100.0
distance
9.940596
seq distance
14
chain
D
EGF-like 2
begin
94
end
134
score
100.0
distance
9.940596
seq distance
14
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
15.975851
seq distance
39
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
15.975851
seq distance
39
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
16.15935
seq distance
25
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
16.15935
seq distance
25
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
16.519634
seq distance
22
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
16.519634
seq distance
23
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
16.519634
seq distance
22
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
16.519634
seq distance
23
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
17.852486
seq distance
53
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
17.852486
seq distance
53
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
20.156239
seq distance
27
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
20.156239
seq distance
27
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
22.575157
seq distance
41
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
22.575157
seq distance
41
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
22.575157
seq distance
41
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
22.575157
seq distance
41
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
22.675049
seq distance
56
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
22.675049
seq distance
56
chain
D
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
24.201185
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
24.201185
seq distance
False
chain
A
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
24.201185
seq distance
False
chain
A
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
24.201185
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
26.728708
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
26.728708
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
29.296368
seq distance
61
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
29.296368
seq distance
61
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
30.80751
seq distance
59
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
30.80751
seq distance
59
chain
D
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
33.70452
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
33.70452
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
34.03923
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
34.03923
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
34.24209
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
34.24209
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
34.59572
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
34.59572
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
34.939907
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
34.939907
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
35.394375
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
35.394375
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
36.424267
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
36.424267
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
37.513817
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
37.513817
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
37.847404
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
37.847404
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
37.847404
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
37.847404
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
38.503876
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
38.503876
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
38.724804
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
38.724804
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
40.070866
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
40.070866
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
40.56272
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
40.56272
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
40.727795
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
40.727795
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
40.994133
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
40.994133
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
41.084267
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
41.084267
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
42.387703
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
42.387703
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
42.387703
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
42.387703
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
42.94262
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
42.94262
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
43.04628
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
43.04628
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
43.04628
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
43.04628
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
43.17364
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
43.17364
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
43.582012
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
43.582012
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
43.742474
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
43.742474
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
43.742474
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
43.742474
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
43.742474
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
43.742474
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
43.79026
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
43.79026
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
44.11117
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
44.11117
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
44.2329
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
44.2329
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
44.735912
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
44.735912
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
45.457394
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
45.457394
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
46.394505
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
46.394505
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
46.77985
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
46.77985
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
47.61204
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
47.61204
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
48.33228
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
48.33228
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
48.970356
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
48.970356
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
49.904373
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
49.904373
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
49.904373
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
49.904373
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
50.574593
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
50.574593
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
52.14715
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
52.14715
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
52.29367
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
52.29367
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.480923
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.480923
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
54.484894
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
54.484894
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
54.81248
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
54.81248
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
54.837273
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
54.837273
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
55.994415
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
55.994415
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
55.994415
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
55.994415
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
67.95411
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
67.95411
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
72.239685
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
72.239685
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
84.90449
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
84.90449
seq distance
False
chain
C
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
106.73107
seq distance
False
chain
B
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
106.73107
seq distance
False
chain
B

Details

Redox score
69.01
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
6.87
Half-sphere exposure sum
58
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
105 (Residue 63 in this structure)
Residue number B
122 (Residue 80 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
2.8083286
seq distance
0
chain
I
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
2.8083286
seq distance
0
chain
I
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
3.5349662
seq distance
7
chain
I
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
3.5349662
seq distance
7
chain
I
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
4.116822
seq distance
4
chain
I
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
4.116822
seq distance
5
chain
I
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
4.116822
seq distance
4
chain
I
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
4.116822
seq distance
5
chain
I
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
6.164545
seq distance
1
chain
I
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
6.164545
seq distance
1
chain
I
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
7.5566115
seq distance
9
chain
I
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
7.5566115
seq distance
9
chain
I
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
8.364836
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
8.364836
seq distance
False
chain
G
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
8.364836
seq distance
False
chain
G
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
8.364836
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
8.980114
seq distance
15
chain
I
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
8.980114
seq distance
15
chain
I
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
10.256926
seq distance
False
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
10.256926
seq distance
False
chain
G
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
10.256926
seq distance
False
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
10.256926
seq distance
False
chain
G
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
12.147293
seq distance
3
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
12.147293
seq distance
3
chain
I
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
12.147293
seq distance
3
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
12.147293
seq distance
3
chain
I
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
12.49289
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
12.49289
seq distance
False
chain
G
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
14.15292
seq distance
False
chain
G
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
14.15292
seq distance
False
chain
G
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
17.139885
seq distance
18
chain
I
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
17.139885
seq distance
18
chain
I
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
18.888601
seq distance
23
chain
I
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
18.888601
seq distance
23
chain
I
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
21.115488
seq distance
False
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
21.115488
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
21.440475
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
21.440475
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
22.568855
seq distance
21
chain
I
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
22.568855
seq distance
21
chain
I
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
22.872587
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
22.872587
seq distance
False
chain
G
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
22.971432
seq distance
False
chain
G
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
22.971432
seq distance
False
chain
G
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
23.030287
seq distance
False
chain
G
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
23.030287
seq distance
False
chain
G
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
23.202297
seq distance
False
chain
G
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
23.202297
seq distance
False
chain
G
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
23.310942
seq distance
False
chain
G
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
23.310942
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
23.489351
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
23.489351
seq distance
False
chain
G
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
23.76005
seq distance
False
chain
G
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
23.76005
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
23.804302
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
23.804302
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
25.331545
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
25.331545
seq distance
False
chain
G
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
25.743551
seq distance
False
chain
G
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
25.743551
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
26.579712
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
26.579712
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
26.579712
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
26.579712
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
27.310825
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
27.310825
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
28.76132
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
28.76132
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
29.138243
seq distance
False
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
29.138243
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
29.138243
seq distance
False
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
29.138243
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
29.460415
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
29.460415
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
29.84946
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
29.84946
seq distance
False
chain
G
Charge relay system
position
299
score
100.0
distance
30.145445
seq distance
False
chain
G
Charge relay system
position
299
score
100.0
distance
30.145445
seq distance
False
chain
G
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
30.553383
seq distance
False
chain
G
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
30.553383
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
30.700584
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
30.700584
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
30.700584
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
30.700584
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
31.030901
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
31.030901
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
31.116093
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
31.116093
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
31.12182
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
31.12182
seq distance
False
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
31.195421
seq distance
False
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
31.195421
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
31.259134
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
31.259134
seq distance
False
chain
G
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
32.334118
seq distance
False
chain
G
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
32.334118
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
32.987785
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
32.987785
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
33.51604
seq distance
False
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
33.51604
seq distance
False
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
33.51604
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
33.51604
seq distance
False
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
33.51604
seq distance
False
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
33.51604
seq distance
False
chain
G
Charge relay system
position
402
score
100.0
distance
33.797226
seq distance
False
chain
G
Charge relay system
position
402
score
100.0
distance
33.797226
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
35.051586
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
35.051586
seq distance
False
chain
G
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
35.1097
seq distance
False
chain
G
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
35.1097
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
35.8938
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
35.8938
seq distance
False
chain
G
Charge relay system
position
253
score
100.0
distance
35.8938
seq distance
False
chain
G
Charge relay system
position
253
score
100.0
distance
35.8938
seq distance
False
chain
G
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
36.744366
seq distance
False
chain
G
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
36.744366
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
37.287685
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
37.287685
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
38.92231
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
38.92231
seq distance
False
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
38.940975
seq distance
False
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
38.940975
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
39.008675
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
39.008675
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
39.040047
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
39.040047
seq distance
False
chain
H
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
39.07192
seq distance
False
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
39.07192
seq distance
False
chain
G
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
41.82726
seq distance
False
chain
A
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
41.82726
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
43.105896
seq distance
False
chain
G
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
43.105896
seq distance
False
chain
G
Phosphoserine; by FAM20C
position
347
score
100.0
distance
43.665806
seq distance
False
chain
G
Phosphoserine; by FAM20C
position
347
score
100.0
distance
43.665806
seq distance
False
chain
G
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
43.695232
seq distance
False
chain
G
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
43.695232
seq distance
False
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
44.992664
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
44.992664
seq distance
False
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
44.992664
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
44.992664
seq distance
False
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
46.80651
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
46.80651
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
46.80651
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
46.80651
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
47.360992
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
47.360992
seq distance
False
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
47.733562
seq distance
False
chain
G
4-carboxyglutamate
position
349
score
50.0
distance
47.733562
seq distance
False
chain
G
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
48.66404
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
48.66404
seq distance
False
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
49.679874
seq distance
False
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
49.679874
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
50.474472
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
50.474472
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
50.634254
seq distance
False
chain
K
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
50.634254
seq distance
False
chain
K
Phosphoserine; by FAM20C
position
347
score
100.0
distance
52.064842
seq distance
False
chain
A
Phosphoserine; by FAM20C
position
347
score
100.0
distance
52.064842
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
53.47831
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
53.47831
seq distance
False
chain
A
Charge relay system
position
7
score
50.0
distance
54.083366
seq distance
False
chain
H
Charge relay system
position
7
score
50.0
distance
54.083366
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
56.700893
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
56.700893
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
56.700893
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
56.700893
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
56.700893
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
56.700893
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
56.883694
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
56.883694
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
57.587025
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
57.587025
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
57.79382
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
57.79382
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
57.905987
seq distance
False
chain
J
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
57.905987
seq distance
False
chain
J
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
58.31
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
58.31
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
59.420685
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
59.420685
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
59.55245
seq distance
False
chain
K
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
59.55245
seq distance
False
chain
K
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
59.80203
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
59.80203
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
61.30103
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
61.30103
seq distance
False
chain
A
Charge relay system
position
402
score
100.0
distance
61.42241
seq distance
False
chain
A
Charge relay system
position
402
score
100.0
distance
61.42241
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
62.057518
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
62.057518
seq distance
False
chain
A
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
62.258972
seq distance
False
chain
A
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
62.258972
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
62.512703
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
62.512703
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
63.328304
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
63.328304
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
63.659824
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
63.659824
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
64.40807
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
64.40807
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
64.52844
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
64.52844
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
64.81363
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
64.81363
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
66.1243
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
66.1243
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
66.1243
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
66.1243
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
66.36841
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
66.36841
seq distance
False
chain
A
Charge relay system
position
253
score
100.0
distance
66.36841
seq distance
False
chain
A
Charge relay system
position
253
score
100.0
distance
66.36841
seq distance
False
chain
A
Charge relay system
position
7
score
50.0
distance
66.61809
seq distance
False
chain
K
Charge relay system
position
7
score
50.0
distance
66.61809
seq distance
False
chain
K
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
67.864006
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
67.864006
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
67.864006
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
67.864006
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
68.48786
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
68.48786
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
69.62571
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
69.62571
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
70.174385
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
70.174385
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
70.73678
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
70.73678
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
70.73678
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
70.73678
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
70.76745
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
70.76745
seq distance
False
chain
A
Charge relay system
position
299
score
100.0
distance
70.82115
seq distance
False
chain
A
Charge relay system
position
299
score
100.0
distance
70.82115
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
70.87564
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
70.87564
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
71.424774
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
71.424774
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
71.53711
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
71.53711
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
71.99796
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
71.99796
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
72.77811
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
72.77811
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
72.86895
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
72.86895
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
73.44588
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
73.44588
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
73.555695
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
73.555695
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
73.70137
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
73.70137
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
74.52292
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
74.52292
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
74.982056
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
74.982056
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
77.67804
seq distance
False
chain
L
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
77.67804
seq distance
False
chain
L
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
78.317566
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
78.317566
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
78.37403
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
78.37403
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
78.39658
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
78.39658
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
78.68825
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
78.68825
seq distance
False
chain
A
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
79.49707
seq distance
False
chain
B
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
79.49707
seq distance
False
chain
B
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
79.8891
seq distance
False
chain
K
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
79.8891
seq distance
False
chain
K
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
80.35762
seq distance
False
chain
B
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
80.35762
seq distance
False
chain
B
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
80.40863
seq distance
False
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
80.40863
seq distance
False
chain
B
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
80.40863
seq distance
False
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
80.40863
seq distance
False
chain
B
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
80.88482
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
80.88482
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
81.26384
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
81.26384
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
81.3195
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
81.3195
seq distance
False
chain
B
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
81.47487
seq distance
False
chain
C
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
81.47487
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
82.11322
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
82.11322
seq distance
False
chain
B
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
82.46535
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
82.46535
seq distance
False
chain
A
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
82.46535
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
82.46535
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
82.61946
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
82.61946
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
83.31079
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
83.31079
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
84.60936
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
84.60936
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
84.6707
seq distance
False
chain
B
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
84.6707
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
85.17445
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
85.17445
seq distance
False
chain
B
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
85.237785
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
85.237785
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
85.237785
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
85.237785
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
86.16249
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
86.16249
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
86.67819
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
86.67819
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
87.882545
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
87.882545
seq distance
False
chain
C
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
88.00408
seq distance
False
chain
B
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
88.00408
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
88.18479
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
88.18479
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
88.18479
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
88.18479
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
92.399055
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
92.399055
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
92.399055
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
92.399055
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
92.399055
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
92.399055
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
93.76127
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
93.76127
seq distance
False
chain
D
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
94.26214
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
94.26214
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
94.42554
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
94.42554
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
94.57956
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
94.57956
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
95.294945
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
95.294945
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
95.44827
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
95.44827
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
96.77544
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
96.77544
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
96.94247
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
96.94247
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
97.4367
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
97.4367
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
98.18658
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
98.18658
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
98.18658
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
98.18658
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
98.415
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
98.415
seq distance
False
chain
D
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
98.61197
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
98.61197
seq distance
False
chain
C
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
99.00018
seq distance
False
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
99.00018
seq distance
False
chain
D
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
99.3049
seq distance
False
chain
D
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
99.3049
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
99.4384
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
99.4384
seq distance
False
chain
C
Charge relay system
position
253
score
100.0
distance
99.4384
seq distance
False
chain
C
Charge relay system
position
253
score
100.0
distance
99.4384
seq distance
False
chain
C
Charge relay system
position
402
score
100.0
distance
99.51158
seq distance
False
chain
C
Charge relay system
position
402
score
100.0
distance
99.51158
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
99.87211
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
99.87211
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
101.345314
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
101.345314
seq distance
False
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
101.73042
seq distance
False
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
101.73042
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
102.92687
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
102.92687
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
103.38297
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
103.38297
seq distance
False
chain
C
Charge relay system
position
299
score
100.0
distance
103.94131
seq distance
False
chain
C
Charge relay system
position
299
score
100.0
distance
103.94131
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
104.08314
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
104.08314
seq distance
False
chain
C
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
104.189285
seq distance
False
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
104.189285
seq distance
False
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
104.189285
seq distance
False
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
104.189285
seq distance
False
chain
D
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
104.96013
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
104.96013
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
347
score
100.0
distance
105.79876
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
347
score
100.0
distance
105.79876
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
106.030174
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
106.030174
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
106.563416
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
106.563416
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
106.602844
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
106.602844
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
106.91026
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
106.91026
seq distance
False
chain
C
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
107.216736
seq distance
False
chain
C
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
107.216736
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
107.55511
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
107.55511
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
107.57988
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
107.57988
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
107.69134
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
107.69134
seq distance
False
chain
D
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
108.432274
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
108.432274
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
108.497116
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
108.497116
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
109.99312
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
109.99312
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
110.10339
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
110.10339
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
110.27622
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
110.27622
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
110.9135
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
110.9135
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
111.546745
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
111.546745
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
112.67298
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
112.67298
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
112.67298
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
112.67298
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
114.33497
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
114.33497
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
114.70739
seq distance
False
chain
F
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
114.70739
seq distance
False
chain
F
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
115.02103
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
115.02103
seq distance
False
chain
D
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
115.39294
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
115.39294
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
116.06915
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
116.06915
seq distance
False
chain
C
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
117.90419
seq distance
False
chain
C
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
117.90419
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
117.96267
seq distance
False
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
117.96267
seq distance
False
chain
D
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
118.07999
seq distance
False
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
118.07999
seq distance
False
chain
C
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
118.07999
seq distance
False
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
118.07999
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
118.125786
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
118.125786
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
119.76689
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
119.76689
seq distance
False
chain
C
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
120.07262
seq distance
False
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
120.07262
seq distance
False
chain
D
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
120.07314
seq distance
False
chain
F
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
120.07314
seq distance
False
chain
F
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
127.78728
seq distance
False
chain
F
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
127.78728
seq distance
False
chain
F
Charge relay system
position
7
score
50.0
distance
129.16089
seq distance
False
chain
F
Charge relay system
position
7
score
50.0
distance
129.16089
seq distance
False
chain
F
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
134.8284
seq distance
False
chain
E
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
134.8284
seq distance
False
chain
E

Details

Redox score
68.56
PDB code
6m3c
Structure name
hapc-h1573 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
7.2
Half-sphere exposure sum
62
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
140
Residue number B
160
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like 1
begin
55
end
90
score
100.0
distance
2.714852
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
100.0
distance
2.714852
seq distance
0
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
2.835032
seq distance
0
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
2.835032
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
3.2595742
seq distance
7
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
3.2595742
seq distance
6
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
3.2595742
seq distance
7
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
3.2595742
seq distance
6
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
4.1727505
seq distance
3
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
4.1727505
seq distance
3
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
4.9140034
seq distance
2
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
4.9140034
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.049427
seq distance
2
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.049427
seq distance
2
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.049427
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.049427
seq distance
2
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.049427
seq distance
2
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.049427
seq distance
2
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
11.293024
seq distance
8
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
11.293024
seq distance
12
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
11.293024
seq distance
12
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
11.293024
seq distance
8
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
11.293024
seq distance
12
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
11.293024
seq distance
12
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
13.949215
seq distance
7
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
13.949215
seq distance
7
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
14.226555
seq distance
5
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
14.226555
seq distance
5
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
16.334274
seq distance
13
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
16.334274
seq distance
14
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
16.334274
seq distance
13
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
16.334274
seq distance
14
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
16.618742
seq distance
8
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
16.618742
seq distance
8
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
17.716223
seq distance
16
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
17.716223
seq distance
16
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
20.0687
seq distance
False
chain
H
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
20.0687
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
22.494287
seq distance
44
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
22.494287
seq distance
44
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
22.656708
seq distance
18
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
22.656708
seq distance
18
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
24.474903
seq distance
30
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
24.474903
seq distance
30
chain
L
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
25.65591
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
25.65591
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
26.936178
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
26.936178
seq distance
False
chain
H
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
28.71428
seq distance
32
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
28.71428
seq distance
32
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
28.71428
seq distance
32
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
28.71428
seq distance
32
chain
L
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
29.58346
seq distance
False
chain
H
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
29.58346
seq distance
False
chain
H
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
30.50165
seq distance
47
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
30.50165
seq distance
47
chain
L
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.671862
seq distance
False
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.671862
seq distance
False
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
31.90255
seq distance
False
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
31.90255
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
32.547443
seq distance
52
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
32.547443
seq distance
52
chain
L
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.56929
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.56929
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.56929
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.56929
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
35.00793
seq distance
50
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
35.00793
seq distance
50
chain
L
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.27175
seq distance
False
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.27175
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.316692
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.316692
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
36.820827
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
36.820827
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
36.83682
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
36.83682
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
38.673664
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
38.673664
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.20132
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.20132
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
39.2441
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
39.2441
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.62758
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.62758
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
39.954357
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
39.954357
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
40.027527
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
40.027527
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.14992
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.14992
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
40.262814
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
40.262814
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
40.604774
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
40.604774
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
40.604774
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
40.604774
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
40.787422
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
40.787422
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
41.018867
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
41.018867
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.801582
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.801582
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
42.26228
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
42.26228
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
43.693184
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
43.693184
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.034966
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.034966
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
45.184864
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
45.184864
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.58901
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.58901
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
45.69066
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
45.69066
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
45.917435
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
45.917435
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
45.961224
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
45.961224
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
45.974167
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
45.974167
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
46.857414
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
46.857414
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
46.857414
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
46.857414
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
46.964115
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
46.964115
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
47.8136
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
47.8136
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
49.310127
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
49.310127
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
50.606457
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
50.606457
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
50.841156
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
50.841156
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
50.841156
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
50.841156
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.438953
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.438953
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
53.46736
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
53.46736
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
53.688847
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
53.688847
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
53.688847
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
53.688847
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
54.14887
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
54.14887
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.20718
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.20718
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.07571
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.07571
seq distance
False
chain
H

Details

Redox score
68.08
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
6.71
Half-sphere exposure sum
55
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
106 (Residue 64 in this structure)
Residue number B
131 (Residue 89 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
2.8474553
seq distance
0
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
2.8474553
seq distance
0
chain
D
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
2.8474553
seq distance
0
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
2.8474553
seq distance
0
chain
D
EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
2.8474553
seq distance
0
chain
D
EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
2.8474553
seq distance
0
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
2.8639696
seq distance
0
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
2.8639696
seq distance
0
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
6.1721063
seq distance
3
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
6.1721063
seq distance
3
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
7.109777
seq distance
2
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
7.109777
seq distance
2
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
7.147066
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
7.147066
seq distance
2
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
7.147066
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
7.147066
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
7.899135
seq distance
13
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
7.899135
seq distance
13
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
7.899135
seq distance
13
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
7.899135
seq distance
13
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
7.899135
seq distance
13
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
7.899135
seq distance
13
chain
D
EGF-like 2
begin
94
end
134
score
100.0
distance
10.555032
seq distance
16
chain
D
EGF-like 2
begin
94
end
134
score
100.0
distance
10.555032
seq distance
16
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
18.90335
seq distance
41
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
18.90335
seq distance
41
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
19.635332
seq distance
55
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
19.635332
seq distance
55
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
20.180115
seq distance
27
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
20.180115
seq distance
27
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
21.382896
seq distance
24
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
21.382896
seq distance
25
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
21.382896
seq distance
24
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
21.382896
seq distance
25
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
22.075005
seq distance
58
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
22.075005
seq distance
58
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
23.456837
seq distance
29
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
23.456837
seq distance
29
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
24.549091
seq distance
43
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
24.549091
seq distance
43
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
24.549091
seq distance
43
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
24.549091
seq distance
43
chain
D
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
26.215042
seq distance
False
chain
A
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
26.215042
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
28.755323
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
28.755323
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
30.009409
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
30.009409
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
30.512424
seq distance
63
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
30.512424
seq distance
63
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
30.76526
seq distance
61
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
30.76526
seq distance
61
chain
D
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
34.97264
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
34.97264
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
35.024925
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
35.024925
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
35.861523
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
35.861523
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
36.942844
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
36.942844
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
37.640816
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
37.640816
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
37.640816
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
37.640816
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
38.088554
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
38.088554
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
38.20895
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
38.20895
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
40.074345
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
40.074345
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
40.096664
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
40.096664
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
40.4436
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
40.4436
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
40.94863
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
40.94863
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
42.59905
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
42.59905
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
42.72357
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
42.72357
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
44.214035
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
44.214035
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
44.214035
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
44.214035
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
44.214035
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
44.214035
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
44.346428
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
44.346428
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
44.6051
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
44.6051
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
45.04066
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
45.04066
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
45.23827
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
45.23827
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
45.45177
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
45.45177
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
45.476433
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
45.476433
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
45.476433
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
45.476433
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
45.76393
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
45.76393
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
46.448772
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
46.448772
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
46.448772
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
46.448772
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
46.587597
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
46.587597
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
47.092922
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
47.092922
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
47.323246
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
47.323246
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
48.000385
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
48.000385
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
48.305748
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
48.305748
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
49.546413
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
49.546413
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
50.164837
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
50.164837
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
50.433266
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
50.433266
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
50.744488
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
50.744488
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
51.041397
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
51.041397
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
52.73947
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
52.73947
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
52.73947
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
52.73947
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
54.418262
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
54.418262
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
54.656124
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
54.656124
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
55.117847
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
55.117847
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
55.507626
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
55.507626
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
56.19313
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
56.19313
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
57.073917
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
57.073917
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
57.073917
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
57.073917
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
58.103287
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
58.103287
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
58.143238
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
58.143238
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
71.89288
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
71.89288
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
76.69655
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
76.69655
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
89.925156
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
89.925156
seq distance
False
chain
C
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
110.58382
seq distance
False
chain
B
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
110.58382
seq distance
False
chain
B

Details

Redox score
67.78
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
7.44
Half-sphere exposure sum
51
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
106 (Residue 64 in this structure)
Residue number B
120 (Residue 78 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
2.8083286
seq distance
0
chain
I
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
2.8083286
seq distance
0
chain
I
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
2.8143137
seq distance
0
chain
I
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
2.8143137
seq distance
0
chain
I
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
3.5349662
seq distance
13
chain
I
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
3.5349662
seq distance
13
chain
I
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
4.585496
seq distance
11
chain
I
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
4.585496
seq distance
11
chain
I
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
5.3418126
seq distance
1
chain
I
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
5.3418126
seq distance
1
chain
I
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
6.230498
seq distance
15
chain
I
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
6.230498
seq distance
15
chain
I
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
6.230498
seq distance
15
chain
I
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
6.230498
seq distance
15
chain
I
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
6.28975
seq distance
3
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
6.28975
seq distance
3
chain
I
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
6.28975
seq distance
3
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
6.28975
seq distance
3
chain
I
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
9.937594
seq distance
False
chain
G
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
9.937594
seq distance
False
chain
G
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
10.384025
seq distance
3
chain
I
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
10.384025
seq distance
3
chain
I
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
11.143931
seq distance
False
chain
G
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
11.143931
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
11.853062
seq distance
8
chain
I
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
11.853062
seq distance
8
chain
I
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
12.413683
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
12.413683
seq distance
False
chain
G
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
14.889371
seq distance
False
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
14.889371
seq distance
False
chain
G
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
14.889371
seq distance
False
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
14.889371
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
15.109503
seq distance
6
chain
I
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
15.109503
seq distance
6
chain
I
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
16.289022
seq distance
False
chain
G
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
16.289022
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
16.93911
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
16.93911
seq distance
False
chain
G
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
17.405313
seq distance
False
chain
G
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
17.405313
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
17.619139
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
17.619139
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
20.374983
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
20.374983
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
21.219126
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
21.219126
seq distance
False
chain
G
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
21.314478
seq distance
False
chain
G
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
21.314478
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
21.464685
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
21.464685
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
21.723192
seq distance
False
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
21.723192
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
21.723192
seq distance
False
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
21.723192
seq distance
False
chain
G
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
22.262236
seq distance
False
chain
G
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
22.262236
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
23.383774
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
23.383774
seq distance
False
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
24.052017
seq distance
False
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
24.052017
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
24.170471
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
24.170471
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
24.571638
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
24.571638
seq distance
False
chain
G
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
25.592972
seq distance
False
chain
G
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
25.592972
seq distance
False
chain
G
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
25.603086
seq distance
False
chain
G
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
25.603086
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
25.667805
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
25.667805
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
26.253649
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
26.253649
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
27.066961
seq distance
False
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
27.066961
seq distance
False
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
27.066961
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
27.066961
seq distance
False
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
27.066961
seq distance
False
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
27.066961
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
27.463331
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
27.463331
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
27.52151
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
27.52151
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
27.52151
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
27.52151
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
27.541851
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
27.541851
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
27.541851
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
27.541851
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
27.567665
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
27.567665
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
27.574253
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
27.574253
seq distance
False
chain
G
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
28.243322
seq distance
False
chain
G
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
28.243322
seq distance
False
chain
G
Charge relay system
position
299
score
100.0
distance
29.46859
seq distance
False
chain
G
Charge relay system
position
299
score
100.0
distance
29.46859
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
29.474186
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
29.474186
seq distance
False
chain
G
Charge relay system
position
402
score
100.0
distance
30.434996
seq distance
False
chain
G
Charge relay system
position
402
score
100.0
distance
30.434996
seq distance
False
chain
G
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
30.973352
seq distance
False
chain
G
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
30.973352
seq distance
False
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
31.36877
seq distance
False
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
31.36877
seq distance
False
chain
G
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
32.027885
seq distance
False
chain
G
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
32.027885
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
32.536373
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
32.536373
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
32.72669
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
32.72669
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
33.74466
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
33.74466
seq distance
False
chain
G
Charge relay system
position
253
score
100.0
distance
33.74466
seq distance
False
chain
G
Charge relay system
position
253
score
100.0
distance
33.74466
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
34.280594
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
34.280594
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
35.11225
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
35.11225
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
36.25846
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
36.25846
seq distance
False
chain
G
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
36.967216
seq distance
False
chain
G
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
36.967216
seq distance
False
chain
G
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
37.728638
seq distance
False
chain
G
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
37.728638
seq distance
False
chain
G
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
37.800903
seq distance
False
chain
G
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
37.800903
seq distance
False
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
37.80668
seq distance
False
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
37.80668
seq distance
False
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
38.560005
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
38.560005
seq distance
False
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
38.560005
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
38.560005
seq distance
False
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
39.982178
seq distance
False
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
39.982178
seq distance
False
chain
G
Phosphoserine; by FAM20C
position
347
score
100.0
distance
41.6146
seq distance
False
chain
G
Phosphoserine; by FAM20C
position
347
score
100.0
distance
41.6146
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
44.341362
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
44.341362
seq distance
False
chain
H
4-carboxyglutamate
position
349
score
50.0
distance
45.289074
seq distance
False
chain
G
4-carboxyglutamate
position
349
score
50.0
distance
45.289074
seq distance
False
chain
G
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
48.343365
seq distance
False
chain
A
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
48.343365
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
49.552517
seq distance
False
chain
K
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
49.552517
seq distance
False
chain
K
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
52.81963
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
52.81963
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
52.81963
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
52.81963
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
53.899693
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
53.899693
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
54.556015
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
54.556015
seq distance
False
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
56.011703
seq distance
False
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
56.011703
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
57.404934
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
57.404934
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
347
score
100.0
distance
58.75373
seq distance
False
chain
A
Phosphoserine; by FAM20C
position
347
score
100.0
distance
58.75373
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
59.954903
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
59.954903
seq distance
False
chain
A
Charge relay system
position
7
score
50.0
distance
60.51596
seq distance
False
chain
H
Charge relay system
position
7
score
50.0
distance
60.51596
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
60.841038
seq distance
False
chain
K
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
60.841038
seq distance
False
chain
K
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
63.117874
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
63.117874
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
63.117874
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
63.117874
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
63.117874
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
63.117874
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
63.226135
seq distance
False
chain
J
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
63.226135
seq distance
False
chain
J
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
63.53759
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
63.53759
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
64.33104
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
64.33104
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
64.54352
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
64.54352
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
64.70971
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
64.70971
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
66.284134
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
66.284134
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
66.42448
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
66.42448
seq distance
False
chain
A
Charge relay system
position
7
score
50.0
distance
66.77128
seq distance
False
chain
K
Charge relay system
position
7
score
50.0
distance
66.77128
seq distance
False
chain
K
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
67.220474
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
67.220474
seq distance
False
chain
A
Charge relay system
position
402
score
100.0
distance
67.72205
seq distance
False
chain
A
Charge relay system
position
402
score
100.0
distance
67.72205
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
68.36306
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
68.36306
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
69.00822
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
69.00822
seq distance
False
chain
A
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
69.29576
seq distance
False
chain
A
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
69.29576
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
69.82518
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
69.82518
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
69.83975
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
69.83975
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
70.11426
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
70.11426
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
71.00241
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
71.00241
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
71.09914
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
71.09914
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
72.0524
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
72.0524
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
72.0524
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
72.0524
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
72.30632
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
72.30632
seq distance
False
chain
A
Charge relay system
position
253
score
100.0
distance
72.30632
seq distance
False
chain
A
Charge relay system
position
253
score
100.0
distance
72.30632
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
74.15231
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
74.15231
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
74.69773
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
74.69773
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
74.69773
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
74.69773
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
75.847626
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
75.847626
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
76.70135
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
76.70135
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
76.70135
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
76.70135
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
76.72989
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
76.72989
seq distance
False
chain
A
Charge relay system
position
299
score
100.0
distance
76.98951
seq distance
False
chain
A
Charge relay system
position
299
score
100.0
distance
76.98951
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
77.32477
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
77.32477
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
77.412796
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
77.412796
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
77.61316
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
77.61316
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
77.65573
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
77.65573
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
77.79277
seq distance
False
chain
K
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
77.79277
seq distance
False
chain
K
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
78.11824
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
78.11824
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
78.905235
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
78.905235
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
79.11418
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
79.11418
seq distance
False
chain
B
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
79.88047
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
79.88047
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
79.962944
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
79.962944
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
80.54658
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
80.54658
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
80.69696
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
80.69696
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
81.85052
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
81.85052
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
83.58252
seq distance
False
chain
L
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
83.58252
seq distance
False
chain
L
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
84.12428
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
84.12428
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
84.49741
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
84.49741
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
84.91946
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
84.91946
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
84.968
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
84.968
seq distance
False
chain
A
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
85.70646
seq distance
False
chain
B
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
85.70646
seq distance
False
chain
B
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
86.53385
seq distance
False
chain
B
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
86.53385
seq distance
False
chain
B
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
86.81901
seq distance
False
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
86.81901
seq distance
False
chain
B
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
86.81901
seq distance
False
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
86.81901
seq distance
False
chain
B
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
86.98016
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
86.98016
seq distance
False
chain
A
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
87.698586
seq distance
False
chain
C
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
87.698586
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
87.96372
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
87.96372
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
88.00047
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
88.00047
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
88.65117
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
88.65117
seq distance
False
chain
B
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
88.680954
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
88.680954
seq distance
False
chain
C
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
89.291145
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
89.291145
seq distance
False
chain
A
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
89.291145
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
89.291145
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
89.60918
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
89.60918
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
91.286125
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
91.286125
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
91.50311
seq distance
False
chain
B
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
91.50311
seq distance
False
chain
B
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
91.662
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
91.662
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
91.662
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
91.662
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
91.85191
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
91.85191
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
91.92101
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
91.92101
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
93.20187
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
93.20187
seq distance
False
chain
B
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
93.750145
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
93.750145
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
93.750145
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
93.750145
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
93.89618
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
93.89618
seq distance
False
chain
C
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
94.84261
seq distance
False
chain
B
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
94.84261
seq distance
False
chain
B
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
98.372055
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
98.372055
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
98.372055
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
98.372055
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
98.372055
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
98.372055
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
99.146355
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
99.146355
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
100.25182
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
100.25182
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
100.4824
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
100.4824
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
100.784164
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
100.784164
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
101.16665
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
101.16665
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
101.46655
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
101.46655
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
102.71252
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
102.71252
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
102.73626
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
102.73626
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
103.93317
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
103.93317
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
103.97158
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
103.97158
seq distance
False
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
104.05912
seq distance
False
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
104.05912
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
104.318695
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
104.318695
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
104.318695
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
104.318695
seq distance
False
chain
C
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
104.547005
seq distance
False
chain
D
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
104.547005
seq distance
False
chain
D
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
105.02559
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
105.02559
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
105.83466
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
105.83466
seq distance
False
chain
C
Charge relay system
position
253
score
100.0
distance
105.83466
seq distance
False
chain
C
Charge relay system
position
253
score
100.0
distance
105.83466
seq distance
False
chain
C
Charge relay system
position
402
score
100.0
distance
105.90678
seq distance
False
chain
C
Charge relay system
position
402
score
100.0
distance
105.90678
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
106.081955
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
106.081955
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
107.10839
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
107.10839
seq distance
False
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
108.529205
seq distance
False
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
108.529205
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
108.97934
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
108.97934
seq distance
False
chain
C
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
109.587975
seq distance
False
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
109.587975
seq distance
False
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
109.587975
seq distance
False
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
109.587975
seq distance
False
chain
D
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
109.69173
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
109.69173
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
109.85747
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
109.85747
seq distance
False
chain
C
Charge relay system
position
299
score
100.0
distance
110.20095
seq distance
False
chain
C
Charge relay system
position
299
score
100.0
distance
110.20095
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
111.20894
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
111.20894
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
112.119965
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
112.119965
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
112.45732
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
112.45732
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
347
score
100.0
distance
112.48163
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
347
score
100.0
distance
112.48163
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
112.79716
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
112.79716
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
112.89754
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
112.89754
seq distance
False
chain
D
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
113.10494
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
113.10494
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
113.24888
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
113.24888
seq distance
False
chain
C
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
113.81152
seq distance
False
chain
C
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
113.81152
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
114.03962
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
114.03962
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
114.73171
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
114.73171
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
115.0186
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
115.0186
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
115.509674
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
115.509674
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
115.545364
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
115.545364
seq distance
False
chain
D
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
116.4071
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
116.4071
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
117.402664
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
117.402664
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
117.76643
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
117.76643
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
118.94514
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
118.94514
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
118.94514
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
118.94514
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
120.3626
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
120.3626
seq distance
False
chain
D
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
120.491165
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
120.491165
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
121.03152
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
121.03152
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
121.42586
seq distance
False
chain
F
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
121.42586
seq distance
False
chain
F
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
121.91267
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
121.91267
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
123.49072
seq distance
False
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
123.49072
seq distance
False
chain
D
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
123.860664
seq distance
False
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
123.860664
seq distance
False
chain
C
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
123.860664
seq distance
False
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
123.860664
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
124.19503
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
124.19503
seq distance
False
chain
C
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
124.36543
seq distance
False
chain
C
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
124.36543
seq distance
False
chain
C
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
125.47784
seq distance
False
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
125.47784
seq distance
False
chain
D
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
125.9789
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
125.9789
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
127.01132
seq distance
False
chain
F
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
127.01132
seq distance
False
chain
F
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
134.62064
seq distance
False
chain
F
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
134.62064
seq distance
False
chain
F
Charge relay system
position
7
score
50.0
distance
135.95433
seq distance
False
chain
F
Charge relay system
position
7
score
50.0
distance
135.95433
seq distance
False
chain
F
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
141.69984
seq distance
False
chain
E
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
141.69984
seq distance
False
chain
E

Details

Redox score
67.65
PDB code
6m3c
Structure name
hapc-h1573 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
7.46
Half-sphere exposure sum
66
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
160
Residue number B
175
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
2.7661178
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
2.7661178
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
3.1860354
seq distance
7
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
3.1860354
seq distance
6
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
3.1860354
seq distance
7
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
3.1860354
seq distance
6
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
4.0853834
seq distance
17
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
4.0853834
seq distance
17
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
4.981074
seq distance
16
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
4.981074
seq distance
16
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
5.832236
seq distance
13
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
5.832236
seq distance
13
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
5.832236
seq distance
13
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
5.832236
seq distance
13
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
5.832236
seq distance
13
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
5.832236
seq distance
13
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.4883623
seq distance
14
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.4883623
seq distance
14
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.291048
seq distance
2
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.291048
seq distance
2
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.291048
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.291048
seq distance
2
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.291048
seq distance
2
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.291048
seq distance
2
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
11.135173
seq distance
17
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
11.135173
seq distance
17
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
14.190886
seq distance
5
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
14.190886
seq distance
5
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
16.339018
seq distance
13
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
16.339018
seq distance
14
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
16.339018
seq distance
13
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
16.339018
seq distance
14
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
17.663523
seq distance
16
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
17.663523
seq distance
16
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
20.1066
seq distance
False
chain
C
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
20.1066
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
22.428732
seq distance
44
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
22.428732
seq distance
44
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
22.693565
seq distance
18
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
22.693565
seq distance
18
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
24.611551
seq distance
30
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
24.611551
seq distance
30
chain
L
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
26.966316
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
26.966316
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
27.54644
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
27.54644
seq distance
False
chain
C
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
28.653355
seq distance
32
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
28.653355
seq distance
32
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
28.653355
seq distance
32
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
28.653355
seq distance
32
chain
L
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
29.79243
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
29.79243
seq distance
False
chain
C
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
30.548046
seq distance
47
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
30.548046
seq distance
47
chain
L
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
31.819038
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
31.819038
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
32.367958
seq distance
52
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
32.367958
seq distance
52
chain
L
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
33.85028
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
33.85028
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
34.99778
seq distance
50
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
34.99778
seq distance
50
chain
L
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
35.835575
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
35.835575
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
35.835575
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
35.835575
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.370464
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.370464
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
36.631447
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
36.631447
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
36.76392
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
36.76392
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
37.14609
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
37.14609
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
38.40428
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
38.40428
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.203587
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.203587
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
39.313705
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
39.313705
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.88439
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.88439
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
39.990612
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
39.990612
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
40.13014
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
40.13014
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
40.538517
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
40.538517
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
40.538517
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
40.538517
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
40.781437
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
40.781437
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
40.89936
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
40.89936
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
40.89936
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
40.89936
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
40.89936
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
40.89936
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
41.09881
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
41.09881
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
41.538
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
41.538
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.88634
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.88634
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
42.3709
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
42.3709
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
42.48857
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
42.48857
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
43.77861
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
43.77861
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
45.45353
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
45.45353
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.69478
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.69478
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
45.871944
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
45.871944
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
45.940865
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
45.940865
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
45.963486
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
45.963486
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
46.026165
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
46.026165
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
46.3709
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
46.3709
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
47.109566
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
47.109566
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
47.152256
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
47.152256
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
47.152256
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
47.152256
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
47.710545
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
47.710545
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
50.269444
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
50.269444
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
50.772186
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
50.772186
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
51.06964
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
51.06964
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
51.06964
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
51.06964
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
52.97922
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
52.97922
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
53.517303
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
53.517303
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
53.76312
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
53.76312
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
53.76312
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
53.76312
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
54.13776
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
54.13776
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.562424
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.562424
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
56.899
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
56.899
seq distance
False
chain
C

Details

Redox score
67.49
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
8.04
Half-sphere exposure sum
52
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
92 (Residue 50 in this structure)
Residue number B
131 (Residue 89 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
2.8251073
seq distance
0
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
2.8251073
seq distance
0
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
2.8251073
seq distance
0
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
2.8251073
seq distance
0
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
2.8525193
seq distance
0
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
2.8525193
seq distance
0
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
4.5710063
seq distance
2
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
4.5710063
seq distance
2
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
4.5710063
seq distance
2
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
4.5710063
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
4.68072
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
4.68072
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
5.1860075
seq distance
14
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
5.1860075
seq distance
14
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
6.235704
seq distance
12
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
6.235704
seq distance
12
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
6.235704
seq distance
12
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
6.235704
seq distance
12
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
9.687556
seq distance
False
chain
C
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
9.687556
seq distance
False
chain
C
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
10.390122
seq distance
3
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
10.390122
seq distance
3
chain
L
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
10.684929
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
10.684929
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
11.317669
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
11.317669
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
11.923473
seq distance
8
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
11.923473
seq distance
8
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
12.938042
seq distance
22
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
12.938042
seq distance
22
chain
L
EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
12.938042
seq distance
15
chain
L
EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
12.938042
seq distance
15
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
14.0236225
seq distance
23
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
14.0236225
seq distance
23
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
15.099943
seq distance
6
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
15.099943
seq distance
6
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
15.6044
seq distance
14
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
15.6044
seq distance
14
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
15.6044
seq distance
14
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
15.6044
seq distance
14
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
15.6044
seq distance
14
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
15.6044
seq distance
14
chain
L
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
16.443813
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
16.443813
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
17.605623
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
17.605623
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
18.276506
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
18.276506
seq distance
False
chain
C
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
20.275946
seq distance
39
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
20.275946
seq distance
39
chain
L
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
20.718313
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
20.718313
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
20.788246
seq distance
38
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
20.788246
seq distance
38
chain
L
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
21.02644
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
21.02644
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
21.420536
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
21.420536
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
21.518053
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
21.518053
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
21.518053
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
21.518053
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
21.557392
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
21.557392
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
21.738556
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
21.738556
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
22.947056
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
22.947056
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
23.289675
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
23.289675
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
23.34058
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
23.34058
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
23.712063
seq distance
41
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
23.712063
seq distance
41
chain
L
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
24.601665
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
24.601665
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
25.29106
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
25.29106
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
25.604723
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
25.604723
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
25.668262
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
25.668262
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
25.785095
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
25.785095
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
26.802319
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
26.802319
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
26.889263
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
26.889263
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
27.062506
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
27.062506
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
27.062506
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
27.062506
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
27.062506
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
27.062506
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
27.124573
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
27.124573
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
27.124573
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
27.124573
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
27.238022
seq distance
29
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
27.238022
seq distance
29
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
27.238022
seq distance
29
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
27.238022
seq distance
29
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
27.238022
seq distance
29
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
27.238022
seq distance
29
chain
L
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
27.474585
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
27.474585
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
27.542538
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
27.542538
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
28.144323
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
28.144323
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
28.144323
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
28.144323
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
29.51008
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
29.51008
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
29.724112
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
29.724112
seq distance
False
chain
C
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
30.014294
seq distance
33
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
30.014294
seq distance
33
chain
L
Charge relay system
position
195
score
100.0
distance
30.45082
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
30.45082
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
31.0984
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
31.0984
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
31.3467
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
31.3467
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
32.46099
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
32.46099
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
32.472866
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
32.472866
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
32.981052
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
32.981052
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
34.04883
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
34.04883
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
34.124374
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
34.124374
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
34.124374
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
34.124374
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
35.09979
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
35.09979
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
35.880825
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
35.880825
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
38.00201
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
38.00201
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
38.287846
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
38.287846
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
38.811157
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
38.811157
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
38.811157
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
38.811157
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
40.124195
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
40.124195
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
43.526608
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
43.526608
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
47.9251
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
47.9251
seq distance
False
chain
C

Details

Redox score
67.21
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
7.85
Half-sphere exposure sum
66
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
147 (Residue 105 in this structure)
Residue number B
175 (Residue 133 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like 2
begin
94
end
134
score
100.0
distance
2.8216136
seq distance
0
chain
D
EGF-like 2
begin
94
end
134
score
100.0
distance
2.8216136
seq distance
0
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
3.5165899
seq distance
13
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
3.5165899
seq distance
13
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
3.7301326
seq distance
13
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
3.7301326
seq distance
13
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
4.6001773
seq distance
1
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
4.6001773
seq distance
1
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
5.9849234
seq distance
1
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
5.9849234
seq distance
1
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
5.9849234
seq distance
1
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
5.9849234
seq distance
1
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
6.130314
seq distance
11
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
6.130314
seq distance
11
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
6.244168
seq distance
15
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
6.244168
seq distance
15
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
6.244168
seq distance
15
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
6.244168
seq distance
15
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
9.235977
seq distance
16
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
9.235977
seq distance
16
chain
D
EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
9.559386
seq distance
28
chain
D
EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
9.559386
seq distance
28
chain
D
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
11.270982
seq distance
False
chain
A
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
11.270982
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
11.9239235
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
11.9239235
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
12.157497
seq distance
21
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
12.157497
seq distance
21
chain
D
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
12.511722
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
12.511722
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
12.57449
seq distance
27
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
12.57449
seq distance
27
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
12.57449
seq distance
27
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
12.57449
seq distance
27
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
12.57449
seq distance
27
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
12.57449
seq distance
27
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
14.882845
seq distance
19
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
14.882845
seq distance
19
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
15.066037
seq distance
35
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
15.066037
seq distance
35
chain
D
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
15.178749
seq distance
36
chain
D
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
15.178749
seq distance
36
chain
D
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
16.537743
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
16.537743
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
17.453026
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
17.453026
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
17.562654
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
17.562654
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
18.796812
seq distance
51
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
18.796812
seq distance
51
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
18.915953
seq distance
52
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
18.915953
seq distance
52
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
19.054178
seq distance
42
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
19.054178
seq distance
42
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
19.054178
seq distance
42
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
19.054178
seq distance
42
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
19.939562
seq distance
54
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
19.939562
seq distance
54
chain
D
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
20.458223
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
20.458223
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
21.595953
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
21.595953
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
21.75152
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
21.75152
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
21.75152
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
21.75152
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
22.013659
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
22.013659
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
22.407492
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
22.407492
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
22.548075
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
22.548075
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
23.8042
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
23.8042
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
23.878065
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
23.878065
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
23.89687
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
23.89687
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
25.548704
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
25.548704
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
26.114594
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
26.114594
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
26.290253
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
26.290253
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
26.682348
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
26.682348
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
26.844793
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
26.844793
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
27.628813
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
27.628813
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
27.628813
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
27.628813
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
27.628813
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
27.628813
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
27.661955
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
27.661955
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
27.661955
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
27.661955
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
27.99755
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
27.99755
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
28.221216
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
28.221216
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
28.464582
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
28.464582
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
28.981663
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
28.981663
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
28.981663
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
28.981663
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
29.12584
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
29.12584
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
29.939037
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
29.939037
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
30.106752
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
30.106752
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
31.413876
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
31.413876
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
31.9241
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
31.9241
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
32.345486
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
32.345486
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
32.577534
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
32.577534
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
32.579052
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
32.579052
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
33.00408
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
33.00408
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
34.40422
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
34.40422
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
34.40422
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
34.40422
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
35.581432
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
35.581432
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
36.068153
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
36.068153
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
38.023586
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
38.023586
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
38.096886
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
38.096886
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
38.521366
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
38.521366
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
39.04866
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
39.04866
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
39.04866
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
39.04866
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
39.467464
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
39.467464
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
40.782887
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
40.782887
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
55.8158
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
55.8158
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
61.63965
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
61.63965
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
73.46539
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
73.46539
seq distance
False
chain
C
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
92.82398
seq distance
False
chain
B
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
92.82398
seq distance
False
chain
B

Details

Redox score
66.99
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
7.86
Half-sphere exposure sum
66
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
160 (Residue 118 in this structure)
Residue number B
162 (Residue 120 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like 1
begin
55
end
90
score
100.0
distance
2.827202
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
100.0
distance
2.827202
seq distance
0
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
2.835032
seq distance
0
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
2.835032
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
3.780042
seq distance
13
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
3.780042
seq distance
14
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
3.780042
seq distance
13
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
3.780042
seq distance
14
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
4.6754613
seq distance
3
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
4.6754613
seq distance
3
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
6.798689
seq distance
2
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
6.798689
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.049427
seq distance
27
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.049427
seq distance
27
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.049427
seq distance
27
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.049427
seq distance
27
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.049427
seq distance
27
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.049427
seq distance
27
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
8.058795
seq distance
8
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
8.058795
seq distance
12
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
8.058795
seq distance
12
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
8.058795
seq distance
8
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
8.058795
seq distance
12
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
8.058795
seq distance
12
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
10.76058
seq distance
7
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
10.76058
seq distance
7
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
13.491087
seq distance
8
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
13.491087
seq distance
8
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
16.999662
seq distance
30
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
16.999662
seq distance
30
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
19.543936
seq distance
38
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
19.543936
seq distance
39
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
19.543936
seq distance
38
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
19.543936
seq distance
39
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
21.569706
seq distance
41
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
21.569706
seq distance
41
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
22.23792
seq distance
False
chain
H
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
22.23792
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
25.65591
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
25.65591
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
25.958477
seq distance
43
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
25.958477
seq distance
43
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
26.016617
seq distance
69
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
26.016617
seq distance
69
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
28.526636
seq distance
55
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
28.526636
seq distance
55
chain
L
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
28.970612
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
28.970612
seq distance
False
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.671862
seq distance
False
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.671862
seq distance
False
chain
H
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
31.89906
seq distance
False
chain
H
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
31.89906
seq distance
False
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
31.90255
seq distance
False
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
31.90255
seq distance
False
chain
H
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
32.403988
seq distance
57
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
32.403988
seq distance
57
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
32.403988
seq distance
57
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
32.403988
seq distance
57
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
33.555904
seq distance
72
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
33.555904
seq distance
72
chain
L
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.56929
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.56929
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.56929
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.56929
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
35.58994
seq distance
77
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
35.58994
seq distance
77
chain
L
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.316692
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.316692
seq distance
False
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.83999
seq distance
False
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.83999
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
38.120483
seq distance
75
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
38.120483
seq distance
75
chain
L
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
38.123524
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
38.123524
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.30866
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.30866
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
39.40515
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
39.40515
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.62758
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.62758
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.14992
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.14992
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
40.262005
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
40.262005
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
40.262814
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
40.262814
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
40.93557
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
40.93557
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
41.160423
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
41.160423
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.82823
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.82823
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
42.118057
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
42.118057
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
42.122623
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
42.122623
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
42.122623
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
42.122623
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
42.122623
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
42.122623
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
43.01894
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
43.01894
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
43.48707
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
43.48707
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
43.573708
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
43.573708
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
43.573708
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
43.573708
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
44.58673
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
44.58673
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
44.89926
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
44.89926
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.034966
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.034966
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.58901
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.58901
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
45.796314
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
45.796314
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
45.84052
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
45.84052
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
46.474262
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
46.474262
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
47.065212
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
47.065212
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
47.8136
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
47.8136
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
47.92713
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
47.92713
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
48.309254
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
48.309254
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
48.309254
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
48.309254
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
48.95321
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
48.95321
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
49.310127
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
49.310127
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
51.312687
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
51.312687
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
51.312687
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
51.312687
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.438953
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.438953
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
52.065113
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
52.065113
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
54.158176
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
54.158176
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
54.158176
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
54.158176
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.20718
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.20718
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
54.306324
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
54.306324
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.07571
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.07571
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
56.431496
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
56.431496
seq distance
False
chain
H

Details

Redox score
66.85
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
7.52
Half-sphere exposure sum
58
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
105 (Residue 63 in this structure)
Residue number B
106 (Residue 64 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like 1
begin
55
end
90
score
100.0
distance
2.714852
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
100.0
distance
2.714852
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
3.2595742
seq distance
7
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
3.2595742
seq distance
6
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
3.2595742
seq distance
7
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
3.2595742
seq distance
6
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
4.1727505
seq distance
2
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
4.1727505
seq distance
2
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
4.285452
seq distance
3
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
4.285452
seq distance
7
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
4.285452
seq distance
7
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
4.285452
seq distance
3
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
4.285452
seq distance
7
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
4.285452
seq distance
7
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
4.9140034
seq distance
3
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
4.9140034
seq distance
3
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.5487614
seq distance
5
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
6.5487614
seq distance
5
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
7.334364
seq distance
2
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
7.334364
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
9.56737
seq distance
3
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
9.56737
seq distance
3
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
14.226555
seq distance
5
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
14.226555
seq distance
5
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
16.334274
seq distance
13
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
16.334274
seq distance
14
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
16.334274
seq distance
13
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
16.334274
seq distance
14
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
17.716223
seq distance
16
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
17.716223
seq distance
16
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
20.0687
seq distance
False
chain
H
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
20.0687
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
22.494287
seq distance
44
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
22.494287
seq distance
44
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
22.656708
seq distance
18
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
22.656708
seq distance
18
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
24.474903
seq distance
30
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
24.474903
seq distance
30
chain
L
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
26.936178
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
26.936178
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
27.350496
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
27.350496
seq distance
False
chain
H
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
28.71428
seq distance
32
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
28.71428
seq distance
32
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
28.71428
seq distance
32
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
28.71428
seq distance
32
chain
L
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
29.58346
seq distance
False
chain
H
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
29.58346
seq distance
False
chain
H
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
30.50165
seq distance
47
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
30.50165
seq distance
47
chain
L
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
31.769258
seq distance
False
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
31.769258
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
32.547443
seq distance
52
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
32.547443
seq distance
52
chain
L
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
33.624836
seq distance
False
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
33.624836
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
35.00793
seq distance
50
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
35.00793
seq distance
50
chain
L
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
35.855236
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
35.855236
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
35.855236
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
35.855236
seq distance
False
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.27175
seq distance
False
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.27175
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
36.820827
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
36.820827
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
36.83682
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
36.83682
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
37.264908
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
37.264908
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
38.673664
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
38.673664
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.20132
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.20132
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
39.2441
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
39.2441
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.820503
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.820503
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
39.954357
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
39.954357
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
40.027527
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
40.027527
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
40.604774
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
40.604774
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
40.604774
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
40.604774
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
40.787422
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
40.787422
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
41.018867
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
41.018867
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
41.42987
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
41.42987
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.801582
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.801582
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
42.26228
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
42.26228
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
42.54154
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
42.54154
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
43.693184
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
43.693184
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
45.184864
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
45.184864
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.6691
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.6691
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
45.69066
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
45.69066
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
45.917435
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
45.917435
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
45.961224
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
45.961224
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
45.974167
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
45.974167
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
46.219593
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
46.219593
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
46.857414
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
46.857414
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
46.857414
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
46.857414
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
46.964115
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
46.964115
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
48.14708
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
48.14708
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
49.84912
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
49.84912
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
50.606457
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
50.606457
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
50.841156
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
50.841156
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
50.841156
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
50.841156
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
53.22761
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
53.22761
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
53.46736
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
53.46736
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
53.688847
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
53.688847
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
53.688847
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
53.688847
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
54.14887
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
54.14887
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.48963
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.48963
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
56.820526
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
56.820526
seq distance
False
chain
H

Details

Redox score
66.36
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
8.37
Half-sphere exposure sum
55
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
111 (Residue 69 in this structure)
Residue number B
131 (Residue 89 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
2.802989
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
2.802989
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
2.802989
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
2.802989
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
2.802989
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
2.802989
seq distance
0
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
3.6718142
seq distance
5
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
3.6718142
seq distance
5
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
6.0044627
seq distance
8
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
6.0044627
seq distance
8
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
7.504991
seq distance
2
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
7.504991
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
7.504991
seq distance
2
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
7.504991
seq distance
2
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
7.504991
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
7.504991
seq distance
2
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
7.828253
seq distance
7
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
7.828253
seq distance
7
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
9.036936
seq distance
13
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
9.036936
seq distance
13
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
9.036936
seq distance
13
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
9.036936
seq distance
13
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
9.036936
seq distance
13
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
9.036936
seq distance
13
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
13.519244
seq distance
6
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
13.519244
seq distance
6
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
17.740208
seq distance
16
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
17.740208
seq distance
16
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
20.221151
seq distance
24
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
20.221151
seq distance
25
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
20.221151
seq distance
24
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
20.221151
seq distance
25
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
20.997341
seq distance
27
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
20.997341
seq distance
27
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
22.181
seq distance
False
chain
C
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
22.181
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
24.796381
seq distance
55
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
24.796381
seq distance
55
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
25.675264
seq distance
29
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
25.675264
seq distance
29
chain
L
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
25.777224
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
25.777224
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
27.86767
seq distance
41
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
27.86767
seq distance
41
chain
L
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
29.802181
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
29.802181
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.738424
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.738424
seq distance
False
chain
C
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
31.451483
seq distance
43
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
31.451483
seq distance
43
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
31.451483
seq distance
43
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
31.451483
seq distance
43
chain
L
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
31.89881
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
31.89881
seq distance
False
chain
C
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
32.392654
seq distance
58
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
32.392654
seq distance
58
chain
L
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
32.88086
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
32.88086
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
34.448414
seq distance
63
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
34.448414
seq distance
63
chain
L
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.540405
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.540405
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.540405
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.540405
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.44348
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.44348
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
36.57469
seq distance
61
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
36.57469
seq distance
61
chain
L
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
37.439156
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
37.439156
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
38.090786
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
38.090786
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
38.86117
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
38.86117
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.82848
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.82848
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.886524
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.886524
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
39.961185
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
39.961185
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.25678
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.25678
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
40.689095
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
40.689095
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
40.906174
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
40.906174
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
41.65773
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
41.65773
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
41.65773
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
41.65773
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
41.65773
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
41.65773
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
41.720333
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
41.720333
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
41.838734
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
41.838734
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
41.838734
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
41.838734
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
42.246872
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
42.246872
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
42.594845
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
42.594845
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
42.611954
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
42.611954
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
44.304058
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
44.304058
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.149208
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.149208
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
45.52223
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
45.52223
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
45.705036
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
45.705036
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.997242
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.997242
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
46.403133
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
46.403133
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
46.48244
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
46.48244
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
46.99762
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
46.99762
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
47.46904
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
47.46904
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
47.64421
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
47.64421
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
47.667744
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
47.667744
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
47.912914
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
47.912914
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
49.264217
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
49.264217
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
49.264217
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
49.264217
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
50.126377
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
50.126377
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.054012
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.054012
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
51.97528
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
51.97528
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
51.97528
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
51.97528
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
52.810696
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
52.810696
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.397335
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.397335
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
54.40558
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
54.40558
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
54.74234
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
54.74234
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
54.74234
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
54.74234
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.179363
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.179363
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
56.33576
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
56.33576
seq distance
False
chain
C

Details

Redox score
66.34
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
8.86
Half-sphere exposure sum
43
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
101 (Residue 59 in this structure)
Residue number B
120 (Residue 78 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like 1
begin
55
end
90
score
100.0
distance
2.714852
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
100.0
distance
2.714852
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
3.2595742
seq distance
7
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
3.2595742
seq distance
6
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
3.2595742
seq distance
7
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
3.2595742
seq distance
6
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
3.562678
seq distance
5
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
3.562678
seq distance
5
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
4.1727505
seq distance
8
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
4.1727505
seq distance
8
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
4.9140034
seq distance
7
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
4.9140034
seq distance
7
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.173938
seq distance
2
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
11.293024
seq distance
13
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
11.293024
seq distance
13
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
11.293024
seq distance
13
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
11.293024
seq distance
13
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
11.293024
seq distance
13
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
11.293024
seq distance
13
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
13.949215
seq distance
12
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
13.949215
seq distance
12
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
14.226555
seq distance
5
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
14.226555
seq distance
5
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
16.334274
seq distance
13
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
16.334274
seq distance
14
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
16.334274
seq distance
13
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
16.334274
seq distance
14
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
16.618742
seq distance
13
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
16.618742
seq distance
13
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
17.716223
seq distance
16
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
17.716223
seq distance
16
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
20.0687
seq distance
False
chain
H
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
20.0687
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
22.494287
seq distance
44
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
22.494287
seq distance
44
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
22.656708
seq distance
18
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
22.656708
seq distance
18
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
24.474903
seq distance
30
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
24.474903
seq distance
30
chain
L
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
25.811314
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
25.811314
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
26.936178
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
26.936178
seq distance
False
chain
H
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
28.71428
seq distance
32
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
28.71428
seq distance
32
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
28.71428
seq distance
32
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
28.71428
seq distance
32
chain
L
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
29.58346
seq distance
False
chain
H
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
29.58346
seq distance
False
chain
H
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
30.50165
seq distance
47
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
30.50165
seq distance
47
chain
L
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.966774
seq distance
False
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.966774
seq distance
False
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
31.92836
seq distance
False
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
31.92836
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
32.547443
seq distance
52
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
32.547443
seq distance
52
chain
L
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.785843
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.785843
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.785843
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.785843
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
35.00793
seq distance
50
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
35.00793
seq distance
50
chain
L
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.27175
seq distance
False
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.27175
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.694885
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.694885
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
36.820827
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
36.820827
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
36.83682
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
36.83682
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
38.673664
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
38.673664
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.20132
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.20132
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
39.2441
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
39.2441
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.820503
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.820503
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
39.954357
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
39.954357
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
40.027527
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
40.027527
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
40.183163
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
40.183163
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.33868
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.33868
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
40.604774
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
40.604774
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
40.604774
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
40.604774
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
40.787422
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
40.787422
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
41.018867
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
41.018867
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
41.030415
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.801582
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.801582
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
42.26228
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
42.26228
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
43.693184
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
43.693184
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
45.184864
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
45.184864
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.22327
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.22327
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.6691
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.6691
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
45.69066
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
45.69066
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
45.917435
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
45.917435
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
45.961224
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
45.961224
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
45.974167
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
45.974167
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
46.857414
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
46.857414
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
46.857414
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
46.857414
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
46.964115
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
46.964115
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
48.14708
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
48.14708
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
49.77167
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
49.77167
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
50.606457
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
50.606457
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
50.841156
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
50.841156
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
50.841156
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
50.841156
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.48795
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.48795
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
53.46736
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
53.46736
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
53.688847
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
53.688847
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
53.688847
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
53.688847
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
54.14887
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
54.14887
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.48963
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.48963
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.15115
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.15115
seq distance
False
chain
H

Details

Redox score
66.21
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
8.7
Half-sphere exposure sum
45
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
101 (Residue 59 in this structure)
Residue number B
131 (Residue 89 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
2.7884195
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
2.7884195
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
2.7884195
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
2.7884195
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
100.0
distance
2.7884195
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
100.0
distance
2.7884195
seq distance
0
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
2.835032
seq distance
0
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
2.835032
seq distance
0
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
5.3000684
seq distance
3
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
5.3000684
seq distance
3
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
6.1241436
seq distance
2
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
6.1241436
seq distance
2
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
7.739659
seq distance
11
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
7.739659
seq distance
11
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
7.739659
seq distance
11
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
7.739659
seq distance
11
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
7.739659
seq distance
11
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
7.739659
seq distance
11
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
11.983361
seq distance
4
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
11.983361
seq distance
4
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
11.983361
seq distance
4
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
11.983361
seq distance
4
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
11.983361
seq distance
4
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
11.983361
seq distance
4
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
12.430002
seq distance
14
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
12.430002
seq distance
14
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
14.480446
seq distance
7
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
14.480446
seq distance
7
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
14.70539
seq distance
22
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
14.70539
seq distance
23
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
14.70539
seq distance
22
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
14.70539
seq distance
23
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
15.846579
seq distance
25
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
15.846579
seq distance
25
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
17.001087
seq distance
8
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
17.001087
seq distance
8
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
18.492807
seq distance
False
chain
H
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
18.492807
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
20.543606
seq distance
53
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
20.543606
seq distance
53
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
20.817116
seq distance
27
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
20.817116
seq distance
27
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
22.53593
seq distance
39
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
22.53593
seq distance
39
chain
L
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
25.384848
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
25.384848
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
25.65591
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
25.65591
seq distance
False
chain
H
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
26.805084
seq distance
41
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
26.805084
seq distance
41
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
26.805084
seq distance
41
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
26.805084
seq distance
41
chain
L
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
27.876883
seq distance
False
chain
H
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
27.876883
seq distance
False
chain
H
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
28.582085
seq distance
56
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
28.582085
seq distance
56
chain
L
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.671862
seq distance
False
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.671862
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
30.747885
seq distance
61
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
30.747885
seq distance
61
chain
L
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
31.90255
seq distance
False
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
31.90255
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
33.20407
seq distance
59
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
33.20407
seq distance
59
chain
L
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.56929
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.56929
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.56929
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.56929
seq distance
False
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
34.869278
seq distance
False
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
34.869278
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
35.090057
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
35.090057
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
35.359272
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
35.359272
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.271595
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.271595
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
36.908768
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
36.908768
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
37.64573
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
37.64573
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
37.9351
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
37.9351
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
38.189663
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
38.189663
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
38.60223
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
38.60223
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
38.6054
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
38.6054
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
38.893406
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
38.893406
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
38.893406
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
38.893406
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
39.259975
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
39.259975
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
39.265015
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
39.265015
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
39.701477
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
39.701477
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
39.701477
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
39.701477
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
39.701477
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
39.701477
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.14992
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.14992
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
40.262814
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
40.262814
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
40.497837
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
40.497837
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
40.554146
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
40.554146
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
42.146
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
42.146
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
43.773674
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
43.773674
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
44.16896
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
44.16896
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
44.32655
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
44.32655
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
44.349426
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
44.349426
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
44.392498
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
44.392498
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
44.495243
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
44.495243
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.034966
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.034966
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
45.247715
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
45.247715
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
45.247715
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
45.247715
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
45.661842
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
45.661842
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
46.94364
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
46.94364
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
48.793125
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
48.793125
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
49.02866
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
49.02866
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
49.414646
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
49.414646
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
49.414646
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
49.414646
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.438953
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.438953
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
52.130684
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
52.130684
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
52.396675
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
52.396675
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
52.396675
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
52.396675
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
52.40474
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
52.40474
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
53.24867
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
53.24867
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.07571
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.07571
seq distance
False
chain
H

Details

Redox score
66.02
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
8.21
Half-sphere exposure sum
54
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
106 (Residue 64 in this structure)
Residue number B
122 (Residue 80 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like 1
begin
55
end
90
score
100.0
distance
2.7323623
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
100.0
distance
2.7323623
seq distance
0
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
3.562678
seq distance
1
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
3.562678
seq distance
1
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
3.780042
seq distance
14
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
3.780042
seq distance
15
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
3.780042
seq distance
14
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
3.780042
seq distance
15
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
4.6754613
seq distance
4
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
4.6754613
seq distance
4
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
6.8292723
seq distance
3
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
6.8292723
seq distance
3
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
8.058795
seq distance
9
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
8.058795
seq distance
13
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
8.058795
seq distance
13
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
8.058795
seq distance
9
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
8.058795
seq distance
13
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
8.058795
seq distance
13
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
9.250706
seq distance
28
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
9.250706
seq distance
28
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
9.250706
seq distance
28
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
9.250706
seq distance
28
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
9.250706
seq distance
28
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
9.250706
seq distance
28
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
10.76058
seq distance
8
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
10.76058
seq distance
8
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
13.491087
seq distance
9
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
13.491087
seq distance
9
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
18.145582
seq distance
31
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
18.145582
seq distance
31
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
20.84228
seq distance
39
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
20.84228
seq distance
40
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
20.84228
seq distance
39
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
20.84228
seq distance
40
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
21.968048
seq distance
42
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
21.968048
seq distance
42
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
23.569319
seq distance
False
chain
H
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
23.569319
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
25.811314
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
25.811314
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
26.016617
seq distance
70
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
26.016617
seq distance
70
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
26.801653
seq distance
44
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
26.801653
seq distance
44
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
28.526636
seq distance
56
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
28.526636
seq distance
56
chain
L
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
30.042526
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
30.042526
seq distance
False
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.966774
seq distance
False
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.966774
seq distance
False
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
31.92836
seq distance
False
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
31.92836
seq distance
False
chain
H
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
32.678764
seq distance
58
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
32.678764
seq distance
58
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
32.678764
seq distance
58
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
32.678764
seq distance
58
chain
L
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
33.100254
seq distance
False
chain
H
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
33.100254
seq distance
False
chain
H
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
33.555904
seq distance
73
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
33.555904
seq distance
73
chain
L
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.785843
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.785843
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.785843
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.785843
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
36.14621
seq distance
78
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
36.14621
seq distance
78
chain
L
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.694885
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.694885
seq distance
False
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
37.57935
seq distance
False
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
37.57935
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
38.120483
seq distance
76
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
38.120483
seq distance
76
chain
L
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
39.134995
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
39.134995
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.973053
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.973053
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
40.080967
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
40.080967
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
40.183163
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
40.183163
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.33868
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.33868
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
40.50601
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
40.50601
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
40.887012
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
40.887012
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
41.893284
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
41.893284
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
42.408
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
42.408
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
42.409306
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
42.409306
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
43.076385
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
43.076385
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
43.076385
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
43.076385
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
43.076385
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
43.076385
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
43.10258
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
43.10258
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
43.573708
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
43.573708
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
43.573708
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
43.573708
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
43.89061
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
43.89061
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
44.656326
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
44.656326
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.22327
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.22327
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
45.688766
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
45.688766
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
45.81486
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
45.81486
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
46.15027
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
46.15027
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
46.44823
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
46.44823
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
46.449505
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
46.449505
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
47.13692
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
47.13692
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
47.56505
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
47.56505
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
48.309216
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
48.309216
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
49.062653
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
49.062653
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
49.227413
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
49.227413
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
49.227413
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
49.227413
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
49.462364
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
49.462364
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
49.77167
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
49.77167
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.48795
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.48795
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
51.95975
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
51.95975
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
51.95975
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
51.95975
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
52.918045
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
52.918045
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.579926
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.579926
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
54.894142
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
54.894142
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
54.894142
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
54.894142
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
55.14828
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
55.14828
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.15115
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.15115
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
57.60203
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
57.60203
seq distance
False
chain
H

Details

Redox score
65.66
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
9.1
Half-sphere exposure sum
48
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
101 (Residue 59 in this structure)
Residue number B
105 (Residue 63 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

EGF-like 2
begin
94
end
134
score
100.0
distance
2.8216136
seq distance
0
chain
D
EGF-like 2
begin
94
end
134
score
100.0
distance
2.8216136
seq distance
0
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
2.892112
seq distance
0
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
2.892112
seq distance
0
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
3.7301326
seq distance
13
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
3.7301326
seq distance
13
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
4.6001773
seq distance
1
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
4.6001773
seq distance
1
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
4.826575
seq distance
2
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
4.826575
seq distance
2
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
4.826575
seq distance
2
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
4.826575
seq distance
2
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
5.9849234
seq distance
1
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
5.9849234
seq distance
1
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
5.9849234
seq distance
1
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
5.9849234
seq distance
1
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
6.130314
seq distance
2
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
6.130314
seq distance
2
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
9.235977
seq distance
16
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
9.235977
seq distance
16
chain
D
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
9.956852
seq distance
False
chain
A
Peptidase S1
begin
18
end
241
score
90.70616883116884
distance
9.956852
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
10.65047
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
10.65047
seq distance
False
chain
A
EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
11.525143
seq distance
15
chain
D
EGF-like 1
begin
55
end
90
score
78.53535353535354
distance
11.525143
seq distance
15
chain
D
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
11.9239235
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
11.9239235
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
12.157497
seq distance
21
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
90.9090909090909
distance
12.157497
seq distance
21
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
14.091175
seq distance
14
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
14.091175
seq distance
14
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
14.091175
seq distance
14
chain
D
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
14.091175
seq distance
14
chain
D
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
14.091175
seq distance
14
chain
D
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
14.091175
seq distance
14
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
14.882845
seq distance
19
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
14.882845
seq distance
19
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
15.947743
seq distance
22
chain
D
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
90.9090909090909
distance
15.947743
seq distance
22
chain
D
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
16.537743
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
16.537743
seq distance
False
chain
A
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
16.72006
seq distance
23
chain
D
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
78
end
82
score
89.0909090909091
distance
16.72006
seq distance
23
chain
D
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
17.453026
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
17.453026
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
17.562654
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
17.562654
seq distance
False
chain
A
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
19.054178
seq distance
29
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
19.054178
seq distance
29
chain
D
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
54.54545454545454
distance
19.054178
seq distance
29
chain
D
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
54.54545454545454
distance
19.054178
seq distance
29
chain
D
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
20.458223
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
20.458223
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
20.462486
seq distance
38
chain
D
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
81.81818181818183
distance
20.462486
seq distance
38
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
20.531784
seq distance
39
chain
D
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
20.531784
seq distance
39
chain
D
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
21.595953
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
21.595953
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
21.75152
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
21.75152
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
21.75152
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
21.75152
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
21.814283
seq distance
41
chain
D
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
21.814283
seq distance
41
chain
D
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
22.013659
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
22.013659
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
22.060905
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
22.060905
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
22.407492
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
22.407492
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
22.548075
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
22.548075
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
23.716944
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
23.716944
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
23.8042
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
23.8042
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
23.878065
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
23.878065
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
26.114594
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
26.114594
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
26.183853
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
26.183853
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
26.290253
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
26.290253
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
26.682348
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
26.682348
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
26.76914
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
26.76914
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
26.844793
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
26.844793
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
27.552225
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
27.552225
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
27.552225
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
27.552225
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
27.628813
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
27.628813
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
27.628813
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
27.628813
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
27.628813
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
27.628813
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
27.661955
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
27.661955
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
27.661955
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
27.661955
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
28.464582
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
100.0
distance
28.464582
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
29.12584
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
29.12584
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
29.939037
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
29.939037
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
30.106752
seq distance
False
chain
A
Charge relay system
position
102
score
100.0
distance
30.106752
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
31.413876
seq distance
False
chain
A
Charge relay system
position
195
score
100.0
distance
31.413876
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
31.9241
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
31.9241
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
31.967344
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
31.967344
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
32.345486
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
32.345486
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
32.579052
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
32.579052
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
32.76034
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
32.76034
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
34.40422
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
34.40422
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
34.40422
seq distance
False
chain
A
Charge relay system
position
57
score
77.27272727272727
distance
34.40422
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
35.581432
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
72.72727272727273
distance
35.581432
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
35.861366
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
216
score
100.0
distance
35.861366
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
37.73796
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
37.73796
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
38.023586
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
38.023586
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
38.521366
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
54.54545454545454
distance
38.521366
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
39.04866
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
39.04866
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
39.04866
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
39.04866
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
39.467464
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
219
score
100.0
distance
39.467464
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
40.782887
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
40.782887
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
55.069183
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
115
score
54.54545454545454
distance
55.069183
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
59.75987
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
59.75987
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
71.41945
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
71.41945
seq distance
False
chain
C
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
92.709885
seq distance
False
chain
B
Peptidase S1
begin
137
end
137
score
154.54545454545453
distance
92.709885
seq distance
False
chain
B

Details

Redox score
65.59
PDB code
6m3b
Structure name
hapc-c25k23 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
8.72
Half-sphere exposure sum
66
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
147 (Residue 105 in this structure)
Residue number B
162 (Residue 120 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
2.7884195
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
2.7884195
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
2.7884195
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
2.7884195
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
100.0
distance
2.7884195
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
100.0
distance
2.7884195
seq distance
0
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
5.3000684
seq distance
13
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
100.0
distance
5.3000684
seq distance
13
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
5.930054
seq distance
4
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
5.930054
seq distance
4
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
5.930054
seq distance
4
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
100.0
distance
5.930054
seq distance
4
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
100.0
distance
5.930054
seq distance
4
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
100.0
distance
5.930054
seq distance
4
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
6.1241436
seq distance
14
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
100.0
distance
6.1241436
seq distance
14
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
7.739659
seq distance
11
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
7.739659
seq distance
11
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
7.739659
seq distance
11
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
7.739659
seq distance
11
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
7.739659
seq distance
11
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
7.739659
seq distance
11
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
8.365122
seq distance
14
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
8.365122
seq distance
14
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
8.688001
seq distance
9
chain
L
(3R)-3-hydroxyaspartate
position
71
score
100.0
distance
8.688001
seq distance
9
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
11.150907
seq distance
8
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
100.0
distance
11.150907
seq distance
8
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
12.430002
seq distance
14
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
12.430002
seq distance
14
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
14.70539
seq distance
22
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
14.70539
seq distance
23
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
14.70539
seq distance
22
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
14.70539
seq distance
23
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
15.846579
seq distance
25
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
15.846579
seq distance
25
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
18.492807
seq distance
False
chain
H
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
18.492807
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
20.543606
seq distance
53
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
20.543606
seq distance
53
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
20.817116
seq distance
27
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
20.817116
seq distance
27
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
22.53593
seq distance
39
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
22.53593
seq distance
39
chain
L
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
25.384848
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
25.384848
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
26.579964
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
26.579964
seq distance
False
chain
H
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
26.805084
seq distance
41
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
26.805084
seq distance
41
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
26.805084
seq distance
41
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
26.805084
seq distance
41
chain
L
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
27.876883
seq distance
False
chain
H
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
27.876883
seq distance
False
chain
H
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
28.582085
seq distance
56
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
28.582085
seq distance
56
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
30.747885
seq distance
61
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
30.747885
seq distance
61
chain
L
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.795376
seq distance
False
chain
H
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.795376
seq distance
False
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
32.846928
seq distance
False
chain
H
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
32.846928
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
33.20407
seq distance
59
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
33.20407
seq distance
59
chain
L
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
34.869278
seq distance
False
chain
H
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
34.869278
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.90195
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.90195
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.90195
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.90195
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
35.090057
seq distance
False
chain
H
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
35.090057
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
35.359272
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
35.359272
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.271595
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.271595
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
36.908768
seq distance
False
chain
H
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
36.908768
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
37.64573
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
37.64573
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
37.9351
seq distance
False
chain
H
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
37.9351
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
38.189663
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
38.189663
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
38.60223
seq distance
False
chain
H
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
38.60223
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
38.6054
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
38.6054
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
38.893406
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
38.893406
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
38.893406
seq distance
False
chain
H
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
38.893406
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
39.259975
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
39.259975
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
39.265015
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
39.265015
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
39.701477
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
39.701477
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
39.701477
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
39.701477
seq distance
False
chain
H
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
39.701477
seq distance
False
chain
H
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
39.701477
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.44666
seq distance
False
chain
H
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.44666
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
40.497837
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
40.497837
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
40.554146
seq distance
False
chain
H
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
40.554146
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
41.85568
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
41.85568
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
42.146
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
42.146
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
43.773674
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
43.773674
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
44.16896
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
44.16896
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
44.32655
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
44.32655
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
44.349426
seq distance
False
chain
H
Charge relay system
position
195
score
100.0
distance
44.349426
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
44.392498
seq distance
False
chain
H
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
44.392498
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
44.495243
seq distance
False
chain
H
Charge relay system
position
102
score
100.0
distance
44.495243
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.193867
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.193867
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
45.247715
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
45.247715
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
45.247715
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
45.247715
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
45.661842
seq distance
False
chain
H
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
45.661842
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
46.94364
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
46.94364
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
48.793125
seq distance
False
chain
H
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
48.793125
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
49.02866
seq distance
False
chain
H
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
49.02866
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
49.414646
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
49.414646
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
49.414646
seq distance
False
chain
H
Charge relay system
position
57
score
77.27272727272727
distance
49.414646
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
52.130684
seq distance
False
chain
H
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
52.130684
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
52.396374
seq distance
False
chain
H
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
52.396374
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
52.396675
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
52.396675
seq distance
False
chain
H
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
52.396675
seq distance
False
chain
H
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
52.396675
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
52.40474
seq distance
False
chain
H
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
52.40474
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
53.24867
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
53.24867
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
56.06086
seq distance
False
chain
H
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
56.06086
seq distance
False
chain
H

Details

Redox score
65.37
PDB code
3f6u
Structure name
crystal structure of human activated protein c (apc) complexed with ppack
Structure deposition date
2008-11-06
Thiol separation (Å)
9.64
Half-sphere exposure sum
50
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
92 (Residue 50 in this structure)
Residue number B
122 (Residue 80 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
2.816018
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
2.816018
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
2.816018
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
2.816018
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
2.816018
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
2.816018
seq distance
0
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
4.0943656
seq distance
3
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
4.0943656
seq distance
4
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
4.0943656
seq distance
4
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
4.0943656
seq distance
3
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
4.0943656
seq distance
4
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
4.0943656
seq distance
4
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
5.505867
seq distance
2
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
5.505867
seq distance
2
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
6.3689404
seq distance
3
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
6.3689404
seq distance
3
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
7.7305503
seq distance
11
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
7.7305503
seq distance
11
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
7.7305503
seq distance
11
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
7.7305503
seq distance
11
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
7.7305503
seq distance
11
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
7.7305503
seq distance
11
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
8.282546
seq distance
5
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
8.282546
seq distance
5
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
9.364864
seq distance
3
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
9.364864
seq distance
3
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
12.404548
seq distance
14
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
12.404548
seq distance
14
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
14.781962
seq distance
22
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
14.781962
seq distance
23
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
14.781962
seq distance
22
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
14.781962
seq distance
23
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
15.782294
seq distance
25
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
15.782294
seq distance
25
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
18.296467
seq distance
False
chain
C
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
18.296467
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
20.398487
seq distance
53
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
20.398487
seq distance
53
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
20.777483
seq distance
27
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
20.777483
seq distance
27
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
22.699535
seq distance
39
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
22.699535
seq distance
39
chain
L
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
25.411146
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
25.411146
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
26.566637
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
26.566637
seq distance
False
chain
C
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
26.673706
seq distance
41
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
26.673706
seq distance
41
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
26.673706
seq distance
41
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
26.673706
seq distance
41
chain
L
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
27.988394
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
27.988394
seq distance
False
chain
C
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
28.535576
seq distance
56
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
28.535576
seq distance
56
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
30.40879
seq distance
61
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
30.40879
seq distance
61
chain
L
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.65385
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.65385
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
32.923428
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
32.923428
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
33.020992
seq distance
59
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
33.020992
seq distance
59
chain
L
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.668705
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.668705
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.668705
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.668705
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
34.802547
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
34.802547
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
34.83895
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
34.83895
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
34.91151
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
34.91151
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
35.85135
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
35.85135
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
36.500763
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
36.500763
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
37.65143
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
37.65143
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
37.668007
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
37.668007
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
38.17123
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
38.17123
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
38.492447
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
38.492447
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
38.544727
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
38.544727
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
38.619267
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
38.619267
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
38.619267
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
38.619267
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
39.018818
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
39.018818
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
39.2743
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
39.2743
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
39.2743
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
39.2743
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
39.2743
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
39.2743
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
39.283424
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
39.283424
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.331978
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.331978
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
40.3849
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
40.3849
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
40.629185
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
40.629185
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
41.511185
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
41.511185
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
42.034245
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
42.034245
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
43.93757
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
43.93757
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
43.99384
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
43.99384
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
44.08984
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
44.08984
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
44.177597
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
44.177597
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
44.323456
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
44.323456
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
44.47291
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
44.47291
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.137737
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.137737
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
45.420406
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
45.420406
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
45.420406
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
45.420406
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
45.691883
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
45.691883
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
46.247936
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
46.247936
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
48.879585
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
48.879585
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
49.13312
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
49.13312
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
49.47967
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
49.47967
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
49.47967
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
49.47967
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.84952
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.84952
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
51.879047
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
51.879047
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
52.178833
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
52.178833
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
52.178833
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
52.178833
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
52.22334
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
52.22334
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
53.195618
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
53.195618
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.780785
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.780785
seq distance
False
chain
C

Details

Redox score
65.03
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
9.54
Half-sphere exposure sum
51
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
111 (Residue 69 in this structure)
Residue number B
122 (Residue 80 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
2.841987
seq distance
0
chain
L
In patients with PROC deficiency; dbSNP:rs199469479.
original residue
C
variation residue
G
position
64
score
100.0
distance
2.841987
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
2.841987
seq distance
0
chain
L
EGF-like 1
begin
55
end
90
score
94.69696969696969
distance
2.841987
seq distance
0
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
5.4335265
seq distance
13
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
5.4335265
seq distance
14
chain
L
In patients with PROC deficiency; St Louis-2.
original residue
variation residue
begin
77
end
82
score
100.0
distance
5.4335265
seq distance
13
chain
L
In patients with PROC deficiency; St Louis-3.
original residue
variation residue
begin
78
end
83
score
100.0
distance
5.4335265
seq distance
14
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
5.832236
seq distance
8
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
5.832236
seq distance
12
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
5.832236
seq distance
12
chain
L
In patients with PROC deficiency.
original residue
variation residue
begin
72
end
76
score
90.9090909090909
distance
5.832236
seq distance
8
chain
L
In patients with PROC deficiency; requires 2 nucleotide substitutions.
original residue
F
variation residue
A
position
76
score
90.9090909090909
distance
5.832236
seq distance
12
chain
L
In patients with PROC deficiency; dbSNP:rs1553424043.
original residue
F
variation residue
L
position
76
score
90.9090909090909
distance
5.832236
seq distance
12
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
6.8849955
seq distance
2
chain
L
In patients with PROC deficiency; La Jolla-1; dbSNP:rs200234655.
original residue
H
variation residue
N
position
66
score
90.9090909090909
distance
6.8849955
seq distance
2
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
7.6375766
seq distance
3
chain
L
In patients with PROC deficiency.
original residue
G
variation residue
R
position
67
score
90.9090909090909
distance
7.6375766
seq distance
3
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.013156
seq distance
27
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.013156
seq distance
27
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.013156
seq distance
27
chain
L
In patients with PROC deficiency; dbSNP:rs774572099.
original residue
R
variation residue
C
position
91
score
50.0
distance
8.013156
seq distance
27
chain
L
In Malakoff; low anticoagulant activity; dbSNP:rs369504169.
original residue
R
variation residue
H
position
91
score
50.0
distance
8.013156
seq distance
27
chain
L
In THPH3; type II; Osaka-10; alters proteolytic processing so that S-42 is the N-terminus of the mature protein; dbSNP:rs774572099.
original residue
R
variation residue
S
position
91
score
50.0
distance
8.013156
seq distance
27
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
11.135173
seq distance
8
chain
L
In THPH3; dbSNP:rs374476971.
original residue
G
variation residue
R
position
72
score
90.9090909090909
distance
11.135173
seq distance
8
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
16.922018
seq distance
30
chain
L
EGF-like 2
begin
94
end
134
score
100.0
distance
16.922018
seq distance
30
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
19.443531
seq distance
38
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
19.443531
seq distance
39
chain
L
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
102
end
103
score
100.0
distance
19.443531
seq distance
38
chain
L
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
103
score
100.0
distance
19.443531
seq distance
39
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
21.428432
seq distance
41
chain
L
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
105
score
100.0
distance
21.428432
seq distance
41
chain
L
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
22.294006
seq distance
False
chain
C
Peptidase S1
begin
18
end
242
score
91.65656565656566
distance
22.294006
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
25.7993
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
133
score
90.9090909090909
distance
25.7993
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
25.90083
seq distance
43
chain
L
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
107
score
100.0
distance
25.90083
seq distance
43
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
26.885878
seq distance
69
chain
L
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
133
score
100.0
distance
26.885878
seq distance
69
chain
L
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
28.908264
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
127
score
59.09090909090909
distance
28.908264
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
28.919426
seq distance
55
chain
L
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
119
score
100.0
distance
28.919426
seq distance
55
chain
L
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.629992
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
162
score
100.0
distance
30.629992
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
32.064026
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
164
score
100.0
distance
32.064026
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
32.07729
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
124
score
86.36363636363636
distance
32.07729
seq distance
False
chain
C
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
32.270557
seq distance
57
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
32.270557
seq distance
57
chain
L
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
121
score
100.0
distance
32.270557
seq distance
57
chain
L
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
121
score
100.0
distance
32.270557
seq distance
57
chain
L
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.495106
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.495106
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
183
score
59.09090909090909
distance
34.495106
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
183
score
59.09090909090909
distance
34.495106
seq distance
False
chain
C
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
35.23343
seq distance
72
chain
L
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
136
score
100.0
distance
35.23343
seq distance
72
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
35.33563
seq distance
77
chain
L
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
141
score
100.0
distance
35.33563
seq distance
77
chain
L
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.192875
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
158
score
100.0
distance
36.192875
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.871487
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
211
score
100.0
distance
36.871487
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
37.886806
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
27
score
100.0
distance
37.886806
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
38.538506
seq distance
75
chain
L
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
139
score
100.0
distance
38.538506
seq distance
75
chain
L
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.29527
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
139
score
100.0
distance
39.29527
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
39.318523
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
120
score
100.0
distance
39.318523
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.621063
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
180
score
86.36363636363636
distance
39.621063
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
40.181538
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
187
score
72.72727272727273
distance
40.181538
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.231236
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
226
score
100.0
distance
40.231236
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
40.240925
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
229
score
100.0
distance
40.240925
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
40.814213
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
47
score
100.0
distance
40.814213
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
40.93722
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
234
score
100.0
distance
40.93722
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.8374
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
213
score
90.9090909090909
distance
41.8374
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
41.951275
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
41.951275
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
41.951275
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
24
score
100.0
distance
41.951275
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
24
score
100.0
distance
41.951275
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
24
score
100.0
distance
41.951275
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
42.104145
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
30
score
100.0
distance
42.104145
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
43.029858
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
48
score
100.0
distance
43.029858
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
43.501
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
238
score
100.0
distance
43.501
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
43.525608
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
43.525608
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
115
score
100.0
distance
43.525608
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
115
score
100.0
distance
43.525608
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
44.5969
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
237
score
100.0
distance
44.5969
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
44.937084
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
44
score
100.0
distance
44.937084
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.132862
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
216
score
72.72727272727273
distance
45.132862
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.582863
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
194
score
100.0
distance
45.582863
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
45.958908
seq distance
False
chain
C
Charge relay system
position
195
score
100.0
distance
45.958908
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
46.009895
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
101
score
100.0
distance
46.009895
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
46.514645
seq distance
False
chain
C
Charge relay system
position
102
score
100.0
distance
46.514645
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
47.152348
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
100
score
100.0
distance
47.152348
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
47.317635
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
142
score
100.0
distance
47.317635
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
47.859146
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
68
score
100.0
distance
47.859146
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
48.519974
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
48.519974
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
104
score
100.0
distance
48.519974
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
104
score
100.0
distance
48.519974
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
48.90358
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
112
score
100.0
distance
48.90358
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
49.761
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
152
score
81.81818181818183
distance
49.761
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.142662
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
146
score
77.27272727272727
distance
51.142662
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
51.49651
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
57
score
77.27272727272727
distance
51.49651
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
51.49651
seq distance
False
chain
C
Charge relay system
position
57
score
77.27272727272727
distance
51.49651
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
52.14271
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
92
score
100.0
distance
52.14271
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
54.187084
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
54.187084
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
74
score
100.0
distance
54.187084
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
74
score
100.0
distance
54.187084
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.21259
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
97
score
100.0
distance
54.21259
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
54.346527
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
75
score
100.0
distance
54.346527
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.19266
seq distance
False
chain
C
In THPH3.
original residue
R
variation residue
C
position
149
score
54.54545454545454
distance
55.19266
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
56.414604
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
84
score
100.0
distance
56.414604
seq distance
False
chain
C

Details

Redox score
63.87
PDB code
1aut
Structure name
human activated protein c
Structure deposition date
1996-06-08
Thiol separation (Å)
9.89
Half-sphere exposure sum
50
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
92 (Residue 50 in this structure)
Residue number B
106 (Residue 64 in this structure)
Peptide name
Vitamin K-dependent protein C
A redox-regulated disulphide may form within Vitamin K-dependent protein C at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.

Relevent regions

In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
2.8038704
seq distance
0
chain
B
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
2.8038704
seq distance
0
chain
B
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
2.8171544
seq distance
0
chain
B
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
2.8171544
seq distance
0
chain
B
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
2.8171544
seq distance
0
chain
B
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
2.8171544
seq distance
0
chain
B
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
3.6667953
seq distance
False
chain
A
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
3.6667953
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
4.5266395
seq distance
26
chain
B
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
4.5266395
seq distance
26
chain
B
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
5.086458
seq distance
14
chain
B
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
5.086458
seq distance
14
chain
B
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
5.4695206
seq distance
12
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
5.4695206
seq distance
12
chain
B
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
5.4695206
seq distance
12
chain
B
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
5.4695206
seq distance
12
chain
B
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
6.5651164
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
6.5651164
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
6.764775
seq distance
28
chain
B
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
6.764775
seq distance
28
chain
B
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
8.19758
seq distance
False
chain
A
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
8.19758
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
8.683027
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
8.683027
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
8.690251
seq distance
2
chain
B
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
8.690251
seq distance
2
chain
B
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
8.715131
seq distance
False
chain
A
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
8.715131
seq distance
False
chain
A
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
10.51074
seq distance
3
chain
B
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
10.51074
seq distance
3
chain
B
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
11.248189
seq distance
30
chain
B
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
11.248189
seq distance
30
chain
B
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
11.812452
seq distance
30
chain
B
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
11.812452
seq distance
30
chain
B
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
12.855518
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
12.855518
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
13.861853
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
13.861853
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
13.883964
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
13.883964
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
13.883964
seq distance
False
chain
A
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
13.883964
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
14.023103
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
14.023103
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
14.476702
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
14.476702
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
15.154599
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
15.154599
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
15.433592
seq distance
False
chain
A
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
15.433592
seq distance
False
chain
A
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
16.513727
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
16.513727
seq distance
False
chain
A
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
16.513727
seq distance
False
chain
A
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
16.513727
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
16.535393
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
16.535393
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
16.695662
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
16.695662
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
16.97488
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
16.97488
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
17.536161
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
17.536161
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
17.728659
seq distance
False
chain
A
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
17.728659
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
18.011435
seq distance
False
chain
A
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
18.011435
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
19.061577
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
19.061577
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
19.061577
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
19.061577
seq distance
False
chain
A
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
19.061577
seq distance
False
chain
A
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
19.061577
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
19.645836
seq distance
False
chain
A
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
19.645836
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
19.8151
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
19.8151
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
19.8151
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
19.8151
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
20.392794
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
20.392794
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
21.503798
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
21.503798
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
21.63403
seq distance
False
chain
A
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
21.63403
seq distance
False
chain
A
Charge relay system
position
402
score
100.0
distance
22.483953
seq distance
False
chain
A
Charge relay system
position
402
score
100.0
distance
22.483953
seq distance
False
chain
A
Charge relay system
position
299
score
100.0
distance
22.810331
seq distance
False
chain
A
Charge relay system
position
299
score
100.0
distance
22.810331
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
22.8732
seq distance
False
chain
A
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
22.8732
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
23.04344
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
23.04344
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
23.178593
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
23.178593
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
23.178593
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
23.178593
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
23.25898
seq distance
False
chain
A
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
23.25898
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
23.420942
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
23.420942
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
23.734255
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
23.734255
seq distance
False
chain
A
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
25.132961
seq distance
False
chain
J
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
25.132961
seq distance
False
chain
J
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
25.924665
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
25.924665
seq distance
False
chain
A
Charge relay system
position
253
score
100.0
distance
25.924665
seq distance
False
chain
A
Charge relay system
position
253
score
100.0
distance
25.924665
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
25.935951
seq distance
False
chain
A
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
25.935951
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
26.117989
seq distance
False
chain
A
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
26.117989
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
26.285828
seq distance
False
chain
A
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
26.285828
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
26.768229
seq distance
False
chain
A
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
26.768229
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
26.913074
seq distance
False
chain
A
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
26.913074
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
27.869871
seq distance
False
chain
A
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
27.869871
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
28.924648
seq distance
False
chain
A
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
28.924648
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
29.281956
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
29.281956
seq distance
False
chain
A
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
29.281956
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
29.281956
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
29.3994
seq distance
False
chain
A
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
29.3994
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
30.830004
seq distance
False
chain
A
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
30.830004
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
31.162664
seq distance
False
chain
A
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
31.162664
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
33.73481
seq distance
False
chain
A
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
33.73481
seq distance
False
chain
A
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
33.993248
seq distance
False
chain
A
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
33.993248
seq distance
False
chain
A
Phosphoserine; by FAM20C
position
347
score
100.0
distance
34.882866
seq distance
False
chain
A
Phosphoserine; by FAM20C
position
347
score
100.0
distance
34.882866
seq distance
False
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
37.53338
seq distance
False
chain
A
4-carboxyglutamate
position
349
score
50.0
distance
37.53338
seq distance
False
chain
A
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
44.03293
seq distance
False
chain
H
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
44.03293
seq distance
False
chain
H
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
46.64574
seq distance
False
chain
G
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
46.64574
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
47.266388
seq distance
False
chain
F
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
47.266388
seq distance
False
chain
F
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
49.52352
seq distance
False
chain
K
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
49.52352
seq distance
False
chain
K
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
49.875103
seq distance
False
chain
C
Peptidase S1
begin
214
end
448
score
99.53578336557061
distance
49.875103
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
51.849197
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
51.849197
seq distance
False
chain
C
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
51.849197
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
51.849197
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
52.724945
seq distance
False
chain
C
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
52.724945
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
55.503952
seq distance
False
chain
G
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
55.503952
seq distance
False
chain
G
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
55.62531
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
55.62531
seq distance
False
chain
C
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
55.9434
seq distance
False
chain
G
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
55.9434
seq distance
False
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
56.029026
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
56.029026
seq distance
False
chain
H
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
56.55661
seq distance
False
chain
G
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
56.55661
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
56.878902
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
56.878902
seq distance
False
chain
G
4-carboxyglutamate
position
349
score
50.0
distance
57.327995
seq distance
False
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
57.327995
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
57.56655
seq distance
False
chain
K
Charge relay system
position
7
score
50.0
distance
57.56655
seq distance
False
chain
K
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
58.29109
seq distance
False
chain
K
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
58.29109
seq distance
False
chain
K
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
58.417118
seq distance
False
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
58.417118
seq distance
False
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
58.867832
seq distance
False
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
58.867832
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
59.055096
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
59.055096
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
59.19091
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
59.19091
seq distance
False
chain
G
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
59.273544
seq distance
False
chain
L
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
59.273544
seq distance
False
chain
L
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
59.743332
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
59.743332
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
59.743332
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
59.743332
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
59.99636
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
59.99636
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
60.218285
seq distance
False
chain
F
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
33
score
50.0
distance
60.218285
seq distance
False
chain
F
Phosphoserine; by FAM20C
position
347
score
100.0
distance
60.32239
seq distance
False
chain
G
Phosphoserine; by FAM20C
position
347
score
100.0
distance
60.32239
seq distance
False
chain
G
Phosphoserine; by FAM20C
position
347
score
100.0
distance
60.608704
seq distance
False
chain
C
Phosphoserine; by FAM20C
position
347
score
100.0
distance
60.608704
seq distance
False
chain
C
4-carboxyglutamate
position
349
score
50.0
distance
61.0751
seq distance
False
chain
G
4-carboxyglutamate
position
349
score
50.0
distance
61.0751
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
61.275517
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
61.275517
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
61.32389
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
61.32389
seq distance
False
chain
C
Charge relay system
position
7
score
50.0
distance
61.492252
seq distance
False
chain
H
Charge relay system
position
7
score
50.0
distance
61.492252
seq distance
False
chain
H
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
61.979103
seq distance
False
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
61.979103
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
62.525757
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
62.525757
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
62.565113
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
62.565113
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
62.565113
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
62.565113
seq distance
False
chain
C
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
62.565113
seq distance
False
chain
C
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
62.565113
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
63.2427
seq distance
False
chain
G
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
63.2427
seq distance
False
chain
G
Charge relay system
position
299
score
100.0
distance
63.799747
seq distance
False
chain
G
Charge relay system
position
299
score
100.0
distance
63.799747
seq distance
False
chain
G
Charge relay system
position
7
score
50.0
distance
63.85465
seq distance
False
chain
F
Charge relay system
position
7
score
50.0
distance
63.85465
seq distance
False
chain
F
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
64.97286
seq distance
False
chain
G
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
64.97286
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
65.38289
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
65.38289
seq distance
False
chain
G
Charge relay system
position
253
score
100.0
distance
65.38289
seq distance
False
chain
G
Charge relay system
position
253
score
100.0
distance
65.38289
seq distance
False
chain
G
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
65.4657
seq distance
False
chain
C
In THPH3.
original residue
C
variation residue
Y
position
426
score
100.0
distance
65.4657
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
65.67955
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
65.67955
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
65.719795
seq distance
False
chain
C
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
65.719795
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
65.744125
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
65.744125
seq distance
False
chain
G
Charge relay system
position
402
score
100.0
distance
66.71575
seq distance
False
chain
G
Charge relay system
position
402
score
100.0
distance
66.71575
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
66.926
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759316085.
original residue
R
variation residue
W
position
394
score
100.0
distance
66.926
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
66.93381
seq distance
False
chain
G
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
66.93381
seq distance
False
chain
G
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
66.98054
seq distance
False
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
66.98054
seq distance
False
chain
G
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
66.98054
seq distance
False
chain
G
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
66.98054
seq distance
False
chain
G
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
67.36942
seq distance
False
chain
F
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
109
score
54.54545454545454
distance
67.36942
seq distance
False
chain
F
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
67.57649
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
67.57649
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
67.74987
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
67.74987
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
67.82535
seq distance
False
chain
G
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
67.82535
seq distance
False
chain
G
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
68.05408
seq distance
False
chain
G
In THPH3; La Jolla-2/Osaka-7 and -8; dbSNP:rs142742242.
original residue
D
variation residue
N
position
401
score
100.0
distance
68.05408
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
68.15606
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
68.15606
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
68.268
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
68.268
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
68.364174
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
variation residue
position
363
score
100.0
distance
68.364174
seq distance
False
chain
C
Charge relay system
position
402
score
100.0
distance
68.457886
seq distance
False
chain
C
Charge relay system
position
402
score
100.0
distance
68.457886
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
68.50168
seq distance
False
chain
K
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
68.50168
seq distance
False
chain
K
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
68.83892
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
68.83892
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
68.873566
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
68.873566
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
68.947655
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
G
variation residue
D
position
343
score
100.0
distance
68.947655
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
69.691414
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
69.691414
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
69.691414
seq distance
False
chain
C
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
69.691414
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
69.7985
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
69.7985
seq distance
False
chain
C
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
70.107445
seq distance
False
chain
I
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
70.107445
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
70.60712
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
70.60712
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
70.60712
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
70.60712
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
70.629486
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
70.629486
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
71.25047
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
S
position
423
score
100.0
distance
71.25047
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
71.45221
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
71.45221
seq distance
False
chain
C
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
71.5509
seq distance
False
chain
G
In THPH3; Vermont-2; dbSNP:rs766261022.
original residue
T
variation residue
M
position
340
score
100.0
distance
71.5509
seq distance
False
chain
G
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
71.66158
seq distance
False
chain
H
In THPH3.
original residue
G
variation residue
S
position
15
score
50.0
distance
71.66158
seq distance
False
chain
H
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
72.12792
seq distance
False
chain
C
In THPH3; Osaka-9; dbSNP:rs756467027.
original residue
G
variation residue
R
position
392
score
100.0
distance
72.12792
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
72.13198
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; dbSNP:rs199469472.
original residue
V
variation residue
L
position
420
score
100.0
distance
72.13198
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
72.341805
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1458669732.
original residue
H
variation residue
Q
position
253
score
100.0
distance
72.341805
seq distance
False
chain
C
Charge relay system
position
253
score
100.0
distance
72.341805
seq distance
False
chain
C
Charge relay system
position
253
score
100.0
distance
72.341805
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
72.582596
seq distance
False
chain
G
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
72.582596
seq distance
False
chain
G
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
72.98403
seq distance
False
chain
C
In patients with PROC deficiency; Purmerend; dbSNP:rs1266965698.
original residue
G
variation residue
S
position
433
score
100.0
distance
72.98403
seq distance
False
chain
C
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
73.22008
seq distance
False
chain
G
Gain of function mutation; abolishes glycosylation at N-313; decreases its catalytic activity; significant loss of its protective effect on endothelial barrier function; increased activation by thrombin.
original residue
T
variation residue
A
position
357
score
100.0
distance
73.22008
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
73.57951
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
A
variation residue
G
position
240
score
100.0
distance
73.57951
seq distance
False
chain
G
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
74.08284
seq distance
False
chain
I
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
74.08284
seq distance
False
chain
I
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
74.12131
seq distance
False
chain
G
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
74.12131
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
74.771545
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
74.771545
seq distance
False
chain
G
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
74.91446
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
74.91446
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
76.04339
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
76.04339
seq distance
False
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
76.47556
seq distance
False
chain
I
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
76.47556
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
76.61707
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
76.61707
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1343264503.
original residue
A
variation residue
T
position
301
score
100.0
distance
76.61707
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918144.
original residue
A
variation residue
V
position
301
score
100.0
distance
76.61707
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
76.64173
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
76.64173
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
A
variation residue
T
position
388
score
100.0
distance
76.64173
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs769277939.
original residue
A
variation residue
V
position
388
score
100.0
distance
76.64173
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
76.88216
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
76.88216
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
77.26136
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918155.
original residue
Q
variation residue
H
position
226
score
100.0
distance
77.26136
seq distance
False
chain
G
Charge relay system
position
299
score
100.0
distance
77.31161
seq distance
False
chain
C
Charge relay system
position
299
score
100.0
distance
77.31161
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
77.55826
seq distance
False
chain
C
In Paris; low anticoagulant activity; dbSNP:rs200721675.
original residue
S
variation residue
N
position
294
score
100.0
distance
77.55826
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
77.57389
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
77.57389
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
78.038055
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
78.038055
seq distance
False
chain
D
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
78.04382
seq distance
False
chain
C
In THPH4; Hong Kong-2.
original residue
G
variation residue
D
position
418
score
100.0
distance
78.04382
seq distance
False
chain
C
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
78.28683
seq distance
False
chain
G
In THPH3; dbSNP:rs774584131.
original residue
I
variation residue
T
position
243
score
100.0
distance
78.28683
seq distance
False
chain
G
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
78.378716
seq distance
False
chain
C
In THPH3.
original residue
T
variation residue
N
position
436
score
100.0
distance
78.378716
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
78.54114
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469483.
original residue
S
variation residue
R
position
223
score
100.0
distance
78.54114
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
78.83129
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
78.83129
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
79.68673
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
79.68673
seq distance
False
chain
I
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
79.783264
seq distance
False
chain
C
In THPH4; neonatal purpura fulmiFalses; dbSNP:rs767730328.
original residue
V
variation residue
A
position
367
score
100.0
distance
79.783264
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
80.3072
seq distance
False
chain
C
In THPH3; also found in patients with PROC deficiency; decrease in vitamin-K dependent serine protease activity; decreased Golgi localization; dbSNP:rs199469471.
original residue
D
variation residue
H
position
297
score
100.0
distance
80.3072
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
81.018715
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
N
variation residue
D
position
298
score
100.0
distance
81.018715
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
81.27345
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
M
variation residue
I
position
385
score
100.0
distance
81.27345
seq distance
False
chain
C
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
81.32133
seq distance
False
chain
G
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
317
score
100.0
distance
81.32133
seq distance
False
chain
G
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
81.61942
seq distance
False
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
81.61942
seq distance
False
chain
I
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
81.61942
seq distance
False
chain
I
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
81.61942
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
81.745895
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs759557871.
original residue
H
variation residue
Y
position
244
score
100.0
distance
81.745895
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
82.173355
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
82.173355
seq distance
False
chain
I
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
82.46099
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
82.46099
seq distance
False
chain
G
In Marseille; low anticoagulant activity; dbSNP:rs752290840.
original residue
R
variation residue
Q
position
271
score
100.0
distance
82.46099
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs767112991.
original residue
R
variation residue
W
position
271
score
100.0
distance
82.46099
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
82.61293
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918156.
original residue
L
variation residue
F
position
265
score
100.0
distance
82.61293
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
82.73369
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs748920874.
original residue
C
variation residue
R
position
183
score
100.0
distance
82.73369
seq distance
False
chain
I
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
82.94962
seq distance
False
chain
C
In THPH4; dbSNP:rs121918150.
original residue
G
variation residue
S
position
334
score
100.0
distance
82.94962
seq distance
False
chain
C
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
83.08047
seq distance
False
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
83.08047
seq distance
False
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
83.08047
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
R
variation residue
P
position
220
score
100.0
distance
83.08047
seq distance
False
chain
G
In THPH3; Vermont-3; dbSNP:rs121918153.
original residue
R
variation residue
Q
position
220
score
100.0
distance
83.08047
seq distance
False
chain
G
In THPH3; dbSNP:rs121918152.
original residue
R
variation residue
W
position
220
score
100.0
distance
83.08047
seq distance
False
chain
G
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
83.88406
seq distance
False
chain
C
In THPH4; dbSNP:rs121918151.
original residue
P
variation residue
L
position
289
score
100.0
distance
83.88406
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
83.974556
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918157.
original residue
I
variation residue
M
position
445
score
100.0
distance
83.974556
seq distance
False
chain
C
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
84.09209
seq distance
False
chain
D
EGF-like 2
begin
138
end
176
score
98.6013986013986
distance
84.09209
seq distance
False
chain
D
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
84.131546
seq distance
False
chain
C
In THPH3; Osaka-6; dbSNP:rs1211098698.
original residue
P
variation residue
L
position
369
score
100.0
distance
84.131546
seq distance
False
chain
C
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
84.4985
seq distance
False
chain
D
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
84.4985
seq distance
False
chain
D
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
84.59824
seq distance
False
chain
G
In patients with PROC deficiency.
original residue
D
variation residue
DLD
position
281
score
100.0
distance
84.59824
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
85.274
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
85.274
seq distance
False
chain
I
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
85.29033
seq distance
False
chain
E
In patients with PROC deficiency; abolishes Golgi localization.
original residue
P
variation residue
S
position
81
score
50.0
distance
85.29033
seq distance
False
chain
E
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
85.44965
seq distance
False
chain
G
In THPH3; dbSNP:rs121918154.
original residue
R
variation residue
C
position
272
score
100.0
distance
85.44965
seq distance
False
chain
G
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
85.468834
seq distance
False
chain
C
In THPH3; Osaka-4; dbSNP:rs753436021.
original residue
Y
variation residue
H
position
441
score
100.0
distance
85.468834
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
85.50444
seq distance
False
chain
C
In THPH3; dbSNP:rs1321566264.
original residue
P
variation residue
L
position
321
score
100.0
distance
85.50444
seq distance
False
chain
C
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
86.13754
seq distance
False
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
86.13754
seq distance
False
chain
D
In THPH4; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
E
position
163
score
100.0
distance
86.13754
seq distance
False
chain
D
In THPH3; drastically reduced secretion; colocalizes with 26S proteasome.
original residue
A
variation residue
V
position
163
score
100.0
distance
86.13754
seq distance
False
chain
D
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
86.72731
seq distance
False
chain
C
In THPH3; dbSNP:rs121918142.
original residue
W
variation residue
C
position
444
score
100.0
distance
86.72731
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
87.87305
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918146.
original residue
A
variation residue
T
position
309
score
100.0
distance
87.87305
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
88.33799
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469474.
original residue
C
variation residue
Y
position
175
score
100.0
distance
88.33799
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
88.50267
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs121918159.
original residue
H
variation residue
P
position
149
score
100.0
distance
88.50267
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
88.95008
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs199469470.
original residue
F
variation residue
V
position
181
score
100.0
distance
88.95008
seq distance
False
chain
I
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
89.646065
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs199469480.
original residue
E
variation residue
V
position
327
score
100.0
distance
89.646065
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
89.82582
seq distance
False
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
89.82582
seq distance
False
chain
G
In patients with PROC deficiency; dbSNP:rs121918160.
original residue
S
variation residue
L
position
312
score
100.0
distance
89.82582
seq distance
False
chain
G
In a patient with PROC deficiency; sporadic case.
original residue
S
variation residue
P
position
312
score
100.0
distance
89.82582
seq distance
False
chain
G
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
91.07125
seq distance
False
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
91.07125
seq distance
False
chain
C
In THPH3; dbSNP:rs201907715.
original residue
R
variation residue
C
position
328
score
100.0
distance
91.07125
seq distance
False
chain
C
In THPH4; Muenchen.
original residue
R
variation residue
H
position
328
score
100.0
distance
91.07125
seq distance
False
chain
C
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
91.46759
seq distance
False
chain
I
In THPH4; Clamart; dbSNP:rs1254257945.
original residue
A
variation residue
P
position
178
score
100.0
distance
91.46759
seq distance
False
chain
I
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
92.64115
seq distance
False
chain
C
In THPH3.
original residue
G
variation residue
R
position
324
score
100.0
distance
92.64115
seq distance
False
chain
C
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
92.84621
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1247269491.
original residue
C
variation residue
Y
position
147
score
100.0
distance
92.84621
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
92.94863
seq distance
False
chain
D
In patients with PROC deficiency; dbSNP:rs1433503391.
original residue
S
variation residue
R
position
161
score
100.0
distance
92.94863
seq distance
False
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
93.22449
seq distance
False
chain
D
In THPH4; neonatal purpura fulmiFalses.
original residue
NG
variation residue
K
begin
144
end
145
score
100.0
distance
93.22449
seq distance
False
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
96.384476
seq distance
False
chain
D
In THPH3; dbSNP:rs370813536.
original residue
G
variation residue
R
position
145
score
100.0
distance
96.384476
seq distance
False
chain
D

Details

Redox score
63.08
PDB code
6m3c
Structure name
hapc-h1573 fab complex
Structure deposition date
2020-03-03
Thiol separation (Å)
9.71
Half-sphere exposure sum
72
Minimum pKa
nan
% buried
nan
Peptide accession
P04070
Residue number A
175
Residue number B
183
Peptide name
Vitamin K-dependent protein C
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